2005
DOI: 10.1097/01.ta.0000171452.96585.84
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Admission Hyperglycemia Is Predictive of Outcome in Critically Ill Trauma Patients

Abstract: Hyperglycemia at admission is an independent predictor of outcome and infection in trauma patients. Future investigation on the effects of hyperglycemia are warranted.

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Cited by 309 publications
(272 citation statements)
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“…The explanation would be that these patients have a more important metabolic response to injury due to the effects of cortisol, glucagon and epinephrine release, causing intrac-pediatric head trauma: hyperglycemia Melo et al ellular acidosis, lactate accumulation, high blood glucose levels and neuronal injury 6,[19][20][21] . Therefore, our data are in accordance with the results from other authors who correlate the head trauma severity and the metabolic response to trauma, particularly higher blood glucose levels 7,22,23 . Some studies show that hyperglycemia is associated with a worse outcome, regardless of injury characteristics 24 .…”
Section: Discussionsupporting
confidence: 83%
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“…The explanation would be that these patients have a more important metabolic response to injury due to the effects of cortisol, glucagon and epinephrine release, causing intrac-pediatric head trauma: hyperglycemia Melo et al ellular acidosis, lactate accumulation, high blood glucose levels and neuronal injury 6,[19][20][21] . Therefore, our data are in accordance with the results from other authors who correlate the head trauma severity and the metabolic response to trauma, particularly higher blood glucose levels 7,22,23 . Some studies show that hyperglycemia is associated with a worse outcome, regardless of injury characteristics 24 .…”
Section: Discussionsupporting
confidence: 83%
“…However, high blood glucose is common in acutely ill neurological patients, even in non-diabetics ones. A consensus regarding the cut-off blood glucose level that would be related to a poor prognosis in children and adolescents with head trauma is still lacking, which makes the comparison of different studies particularly troublesome [3][4][5][6][7][8][9] .…”
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confidence: 99%
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“…1,[6][7][8]20,21 The association of hyperglycemia with increased mortality has been demonstrated in several populations of critically ill human patients, suffering from both medical and surgical conditions and comprising different age groups. [1][2][3][4][5][6][7][8][9] Blood glucose concentrations at admission have been revealed to be associated with survival to hospital discharge in horses with colic, with higher blood glucose concentrations being associated with a less favorable prognosis. 11,12 The degree of hyperglycemia in human patients is associated with the severity of the disease.…”
Section: Discussionmentioning
confidence: 99%
“…4 It has been associated with adverse clinical outcomes, including increased mortality, increased duration of mechanical ventilation, increased intensive care unit (ICU) and hospital stay, and increased risk of infection. [5][6][7][8] Hyperglycemia in critical illness is managed with exogenous insulin as standard treatment; however, there is considerable disagreement among experts in the field as to what target blood glucose level is optimal for the critically ill patient. Conventionally, the aim of insulin therapy has been to maintain blood glucose levels below the renal threshold, typically 220 mg/dL (12.2 mmol/L).…”
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confidence: 99%