“…As one of the chief components of the ECM, hyaluronan distributes widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi, and can be very large in molecular weight (often reaching the millions) [72]. HA plays several important organizational roles in the ECM by binding with cells and other protein components through specific and nonspecific interactions [73] and is responsible for various functions within the ECM such as cell growth, proliferation, differentiation, migration [74], and even some malignant tumors [76].…”