Administration of yoghurt or<i>lactobacillus casei</i>to malnourished mice: Comparative effect on lymphoid cells and mucosal reconditioning of the intestine

Agüero, Graciela; Sánchez, Sara S.; Fernández, Silvia N.; Allori, C.; Holgado, A. Pesce De Ruiz; Perdigón, Gabriela

doi:10.1080/09540109609354922

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…thermophilus) to the diet of Balb/c mice resulted in a significant increase in IgA-secreting cells in the small intestine after 7 d, but such an increase was no longer observed after 10 d of yogurt feeding (32). Similarly, in protein-energydeficient mice (given a protein-free diet), supplementation with 3 mL of the same yogurt preparation for only two consecutive days was associated with significantly higher numbers of IgA-and IgM-secreting cells in the ileum compared to animals supplemented with undiluted milk (33). A group supplemented with L. casei exhibited intermediate responses.…”

Section: Intestinal Microflora Lab and Immune Functionsmentioning

confidence: 68%

The influence of yogurt/lactobacillus on the innate and acquired immune response

Borchers

Keen

Gershwin

2002

Clinic Rev Allerg Immunol

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Section: Intestinal Microflora Lab and Immune Functionsmentioning

confidence: 68%

The influence of yogurt/lactobacillus on the innate and acquired immune response

Borchers

Keen

Gershwin

2002

Clinic Rev Allerg Immunol

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“…In previous works, it has been demonstrated that some lactic acid bacteria and yogurt can induce intestinal mucosal immunity (1,24) and that L. casei can be used as oral adjuvant to induce a protective immunity in the gut (20,23). However, we have demonstrated that some lactic acid bacteria were able to increase the Ig A 1 B lymphocytes in bronchus tissue (21).…”

mentioning

confidence: 73%

Effect of Lactobacillus casei and Yogurt Administration on Prevention of Pseudomonas aeruginosa Infection in Young Mice

Alvarez

Herrero

Bru

et al. 2001

Journal of Food Protection

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Pseudomonas aeruginosa is an opportunistic pathogen that rarely causes pulmonary disease in normal hosts but one that is an important cause of acute pneumonia in immunocompromised patients, including neonates, and of chronic pneumonia in patients with cystic fibrosis. The aim of this work was to study the effect of oral administration of Lactobacillus casei and yogurt on prevention of P. aeruginosa lung infection in young mice (3 weeks old). This study demonstrates that oral administration of L. casei or yogurt to young mice enhanced lung clearance of P. aeruginosa and phagocytic activity of alveolar macrophages through a dose-dependent effect. There were, however, no significant differences in white blood cell (WBC) differential counts. Furthermore, it was observed that previous administration of L. casei or yogurt induced a significant increase in IgA and IgM levels in bronchoalveolar lavages (BALs) after a P. aeruginosa infection, although there was no relationship with the serum values.

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“…Many investigators have studied the therapeutic and preventive effects of yoghurt and lactic acid bacteria (LAB), which are commonly used in yoghurt production, on diseases such as cancer, infection and gastrointestinal disorders (Meydani & Ha, 2000). In particular, a simulated commercial yoghurt prepared from a stock culture of LAB containing L. bulgaricus and S. thermophilus from the Centro de Referencia para Lactobacilos (CERELA) culture collection has been reported to prevent bacterial translocation in malnourished mice (Agüero et al 1996), increase the number of IgAþ cells in the lamina propria of the small intestine and improve the resistance to enteropathogens (Gauffin & Perdigón, 2003). In addition, two bacteria present in the yoghurt, L. bulgaricus CRL 423 and S. thermophilus CRL 412, can increase the number of IgAþ cells in the gut and bronchus when individually administered (Perdigón et al 1998).…”

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confidence: 99%

Yoghurt accelerates the recovery of defence mechanisms againstStreptococcus pneumoniaein protein-malnourished mice

et al. 2006

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Experiments studied the effect of yoghurt on the recovery of defence mechanisms against Streptococcus pneumoniae respiratory infection in malnourished mice. Weaned mice were malnourished with a protein-free diet (PFD) for 21 d. Malnourished mice were made replete with a balanced diet (BD), yoghurt, or the BD with supplemental yoghurt (BD þ Y) for 7, 14 or 21 d. The normal control (NC) group was fed the BD whereas malnourished control (MC) mice consumed only the PFD. Mice were challenged with pneumococci at the end of each dietary treatment. MC mice showed increased susceptibility to pneumococcal infection. Blood leucocytes, phagocyte activity and serum and bronco-alveolar anti-pneumococcal IgG and IgA were significantly lower in the MC than in the NC group. Repletion of malnourished mice with the BD for 21 d was necessary to obtain a response to infection similar to that of NC mice; however, administration of the BD þ Y for 14 d was enough to normalise the immune defence mechanisms. Histological examination of MC lungs showed progressive loss of alveolar architecture. Lung injuries were significantly less pronounced in NC mice. Mice treated with the BD þ Y for 14 d showed histological signs similar to the NC group. The present study showed that administration of yoghurt to malnourished mice induced an early recovery of the immunological parameters studied. Despite the uncertainties about the mechanisms involved and about the human relevance of the effects observed in animal models, the present study provides a strong rationale for the hypothesis that yoghurt consumption by malnourished hosts will accelerate the recovery of the immune mechanisms involved in the protection against respiratory infections.

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Administration of yoghurt orlactobacillus caseito malnourished mice: Comparative effect on lymphoid cells and mucosal reconditioning of the intestine

Cited by 9 publications

References 19 publications

The influence of yogurt/lactobacillus on the innate and acquired immune response

The influence of yogurt/lactobacillus on the innate and acquired immune response

Effect of Lactobacillus casei and Yogurt Administration on Prevention of Pseudomonas aeruginosa Infection in Young Mice

Yoghurt accelerates the recovery of defence mechanisms againstStreptococcus pneumoniaein protein-malnourished mice

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