Administration of Traditional Chinese Blood Circulation Activating Drugs for Microvascular Complications in Patients with Type 2 Diabetes Mellitus

Abstract

Traditional Chinese medicine (TCM) is an important complementary strategy for treating diabetes mellitus (DM) in China. Traditional Chinese blood circulation activating drugs are intended to guide an overall approach to the prevention and treatment of microvascular complications of DM. The core mechanism is related to the protection of the vascular endothelium and the basement membrane. Here, we reviewed the scientific evidence underpinning the use of blood circulation activating drugs to prevent and treat DM-induced microvascular complications, including diabetic nephropathy (DN), diabetic peripheral neuropathy (DPN), and diabetic retinopathy (DR). Furthermore, we summarized the effects and mechanism of TCM on improving blood rheology, inhibiting aggregation of platelet, forming advanced glycation end products (AGEs), regulating oxidative stress, reducing blood fat, and improving lipid metabolism. The paper provides a new theoretical basis for the clinical practice of TCM in the prevention and treatment of DM and its microvascular complications.

Effects of Emodin on Blood Glucose and Body Weight in Type 1 Diabetic Rats

“…Changes in blood glucose and body weight before and after the establishment of type 1 diabetes model There was no significant difference in fasting blood glucose and body weight among the three groups in the initial stage of model construction; the rat weight of diabetes group and emodin group was obviously lower compared with the result obtained from fifth and fifteenth days after successful model construction with the weight in the diabetes group decreasing more significantly (P<0.05): (1). comparison between T2 and T1 in diabetes group: t=3.8607, P=0.0006; (2).comparison of T2 between diabetes group and control group: t=32.4768, P=0.0000; (3) comparison between T2 and T1 in emodin group: t=4.2950, P=0.0002; (4). comparison of T2 between emodin group and control group: t=7.2111, P=0.0000; (5).…”

“…comparison of T2 between diabetes group and control group: t=27.4700, P=0.0000; (3). comparison between T2 and T1 in emodin group: t=7.3288, P=0.0000; (4). comparison of T2 between emodin group and control group: t=7.2111, P =0.0000; (5).…”

Chinese herbal medicine Tangshen Formula Treatment For Type 2 Diabetic Kidney Disease in Early Stage : study protocol for a randomized controlled trial

“…It is urgent to seek an effective preventive measure to delay DKD. CHMs have been common in treating DM [37][38][39][40][41][42]and its complications [43][44][45], including DKD. In modern times, Many patients have turned to Chinese herbal medicine for treatment as a complementary and basic combinationdrug therapy for kidney disease in China due to its fewer adverse reactions and more effective interventions.…”

Chinese herbal medicine Tangshen Formula Treatment For Type 2 Diabetic Kidney Disease in Early Stage : study protocol for a randomized controlled trial

“…It is urgent to seek an effective preventive measure to delay DKD. CHMs have been common in treating DM [37][38][39][40][41][42]and its complications [43][44][45], including DKD. In modern times, many patients have turned to Chinese herbal medicine for treatment as a complementary and necessary combination-drug therapy for kidney disease in China due to its fewer adverse reactions and more effective interventions.…”