Administration of the Combination Clonazepam-Deanxit as Treatment for Tinnitus

Meeus, Olivier; Ridder, Dirk De; Heyning, Paul Van de

doi:10.1097/mao.0b013e31820e737c

Cited by 44 publications

(17 citation statements)

References 34 publications

(33 reference statements)

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“…Clonazapam has shown improvement in tinnitus in one study 41 , while another study suggests clonazepam is only effective when used in combination with Deanxit 42 . In contrast, one clinical trial determined no efficacy with Bartels 43 .…”

Section: Resultsmentioning

confidence: 99%

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Ziai¹,

Moshtaghi²,

Mahboubi³

et al. 2017

The International Tinnitus Journal

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Objectives: To review literature on the link between depression and anxiety in patients suffering from tinnitus. Method: A systematic review of published English-language literature was performed using PubMed, Ovid, and Cochrane databases. Results: Of the 56 eligible abstracts 15 were chosen to be included in the review. All articles showed an association of depression and anxiety in tinnitus patients. Conclusions: Because of the strong association between tinnitus, depression, and anxiety-all tinnitus patients should be screened for psychiatric disorders. Treatment for these complex conditions should involve a multidisciplinary team with cognitive behavioral therapy and possible pharmacological therapy.

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Section: Resultsmentioning

confidence: 99%

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Ziai¹,

Moshtaghi²,

Mahboubi³

et al. 2017

The International Tinnitus Journal

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“…32 Resting state sourcelocalized standardized low-resolution electromagnetic tomography (sLORETA) 35 EEG was performed to visualize abnormal brain activity, which could be used as a target for noninvasive neuromodulation. Treatment with flupentixol plus melitracen (Deanxit) and clonazepam 29 did not benefit the patient, nor did cyclobenzaprine, 52 naltrexone, 45 or acamprosate. 1 A small improvement on the right side was noted by wearing a combination hearing aid and noise masker to a score of 8/10 for loudness but 10/10 for distress on an NRS.…”

Section: History and Examinationmentioning

confidence: 99%

“…All episodic artifacts were removed from the stream of the EEG. Average Fourier cross-spectral matrices were computed for bands delta (2-3.5 Hz), theta (4-7.5 Hz), alpha (8-12 Hz), beta (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and gamma (30.5-45 Hz).…”

Section: Connectivity Changes Between Cases 1 Andmentioning

confidence: 99%

Anterior cingulate implants for tinnitus: report of 2 cases

Ridder

Joos

Vanneste

2016

JNS

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893case report J Neurosurg 124: [893][894][895][896][897][898][899][900][901] 2016 N oNpulsatile tinnitus is the perception of a sound in the absence of an external source and is therefore often considered a phantom sound. 30 It is related to abnormal activity in the auditory and nonauditory brain areas, 48 which can be altered by neuromodulation techniques. 24 As tinnitus is most commonly related to auditory deafferentation 20 with 30,31 or without 59 audiometric hearing loss, it has been regarded as maladaptive auditory memory traces 5 attempting to reduce the inherent auditory uncertainty associated with auditory deafferentation.11 Apart from abnormal activity, pathological functional connectivity is also associated with the presence of tinnitus as demonstrated by electroencephalography (EEG), 57 magnetoencephalography (MEG), 38,39 and functional MRI (fMRI). 26,27 Thus, it has been proposed that the phenomenologically unified percept of tinnitus can be considered an emergent property of multiple, parallel, dynamically changing, and partially overlapping subnetworks, each with a specific spontaneous oscillatory pattern and functional connectivity signature. 17 Functional imaging studies using source-localized EEG and MEG have shown that tinnitus distress is related to a network involving the anterior cingulate cortex (ACC), anterior insula, and parahippocampal area, 6,22,56 whereas the auditory cortex is involved in the perceived tinnitus intensity. 44 The distress subnetwork is predominantly lateralized to the right, in contrast to a similar network encoding depression that is lateralized to the left. 21 The loudness and distress networks are clearly separable even though they interact. Communication between these different subnetworks is proposed to occur at hubs, brain areas that are involved in multiple subnetworks simultaneously. These hubs can take part in each separable subnetwork at different frequencies. ComabbreviatioNs ACC = anterior cingulate cortex; BA = Brodmann area; BOLD = blood oxygen level-dependent; d = dorsal; DLPFC = dorsolateral prefrontal cortex; EEG = electroencephalography; fMRI = functional MRI; HADS = Hospital Anxiety Depression Scale; MEG = magnetoencephalography; NRS = numeric rating scale; r = repetitive; sg = subgenual; sLORETA = standardized low-resolution electromagnetic tomography; tDCS = transcranial direct current stimulation; TENS = transcutaneous electrical nerve stimulation; TMS = transcranial magnetic stimulation; TQ = tinnitus questionnaire. Tinnitus can be distressful, and tinnitus distress has been linked to increased beta oscillatory activity in the dorsal anterior cingulate cortex (dACC). The amount of distress is linked to alpha activity in the medial temporal lobe (amygdala and parahippocampal area), as well as the subgenual (sg)ACC and insula, and the functional connectivity between the parahippocampal area and the sgACC at 10 and 11.5 Hz. The authors describe 2 patients with very severely distressing intractable tinnitus who underwent transcranial magnetic st...

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“…Studies published on the effect of placebo are conclusive and describe that the placebo effect has a short short-term perspective with normal duration of minutes or hours up to a few days 25 . Several placebo-controlled studies on drug treatment of tinnitus with significant tinnitus reduction different from placebo followed a 3 to 4 weeks regimen, one week washout and 3 weeks of placebo 5,26 . The result also indicates a tendency of a more rapid onset of treatment effects in tinnitus patients absent of concurrent diseases.…”

Section: Tinnitus Severity Questionnairementioning

confidence: 99%

Pilot Investigation of a Topographical Filter Dermal Patch in Patients with Tinnitus

Ahnblad¹

2017

The International Tinnitus Journal

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Objective: A new topographical filter in a dermal administration patch that organizes water molecules has been suggested as an alternative treatment for manifested tinnitus. The aim of this study was to evaluate this patch in a pilot study. Materials and Methods: 12 patients were included (10 completed) in an open study all receiving treatment with daily changed patches. The objectives were to evaluate safety and performance of the patch during and after treatment. The primary objective was to evaluate the tinnitus severity (by Tinnitus Severity Questionnaire, TSQ) and tinnitus annoyance (by Visual Analogue Scale, VAS). The secondary objective was to evaluate if the patch could improve the patient's quality of life (by SF-36 Quality of life questionnaire) and sleep initiation time (self-rated). Results: At visit 4, after 21 days of treatment, an improvement (decrease in TSQ score) was seen in 5 responder patients, which was sustained at the post-treatment visit. A marginal increase in TSQ score was seen also initially in 5 non-responder patients, 4 of which were responders post-treatment. The rated tinnitus annoyance, quality of life and sleep initiation time did not show significant changes. The safety evaluation did not present any safety concerns. Conclusion: This small pilot study indicates that it can be reasonable to recommend on a risk-benefit and safety perspective treatment with the dermal patch to patients with tinnitus as a consumer product based on the lack of other effective alternative treatment. Further and larger studies, and also proven experience, are recommended for stronger evidence.

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Administration of the Combination Clonazepam-Deanxit as Treatment for Tinnitus

Abstract: Although tinnitus reduction was recorded as modest, this article provides valuable data demonstrating a placebo-controlled tinnitus reduction after clonazepam and Deanxit intake.

Cited by 44 publications

References 34 publications

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Anterior cingulate implants for tinnitus: report of 2 cases

Pilot Investigation of a Topographical Filter Dermal Patch in Patients with Tinnitus

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