Administration of Recombinant Human Growth Hormone Normalizes GH-IGF1 Axis and Improves Malnutrition-related Disorders in Patients with Anorexia Nervosa

Hashizume, Kiyoshi; Suzuki, Satoru; A, Komatsu; Hiramatsu, Kohzy; Mori, Junichiro; Yamazaki, Masanori; Takeda, Teiji; Kakizawa, Tomoko; Miyamoto, Takahide; Koizumi, Yukio; Ichikawa, Kazuo

doi:10.1507/endocrj.k05-178

Cited by 19 publications

(11 citation statements)

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“…Interestingly, a typical feature of undernutrition is the disruption of the GH-IGF-1 axis characterized by low plasma level of IGF-1 (Hashizume et al, 2007;Zamboni et al, 1996), which is essential for phosphorylation of S6K-1 (Dickson et al, 2001). Hence, S6K-1 is under the control of IGF-1, and the decreased expression of S6K-1 observed in this study might also be a consequence of decreased levels of IGF-1.…”

Section: Discussionmentioning

confidence: 53%

“…This is a result mainly of food restriction either by hunger or diseases like anorexia nervosa (Gatward, 2007;Hashizume et al, 2007). When protein deficiency is predominant, the condition is classically known as Kwashiorkor and has a chronic character.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, the available data is limited, but a decrease in pancreatic acinar size, and reduced number of zymogen granuli and golgi complex are observed in patients suffering of AIDS with protein/ energy deficit (Chehter et al, 2003), indicating that the same Available online at www.sciencedirect.com Life Sciences 82 (2008) 542 -548 www.elsevier.com/locate/lifescie pancreatic features occur in human malnutrition states. These characteristics may be consequence of reduced somatomedin levels (Hashizume et al, 2007) that is observed, for instance, in patients suffering from anorexia nervosa. Several studies associate the control of gene expression with nutritional signals (Foufelle et al, 1998;Pegorier, 1998;Srinivasan et al, 2001;Towle, 1995;Vaulont and Kahn, 1994).…”

Section: Introductionmentioning

confidence: 96%

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Impaired insulin secretion and decreased expression of the nutritionally responsive ribosomal kinase protein S6K-1 in pancreatic islets from malnourished rats

et al. 2008

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Impaired insulin secretion and decreased expression of the nutritionally responsive ribosomal kinase protein S6K-1 in pancreatic islets from malnourished rats

et al. 2008

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“…[14] Rekombinant insan büyüme hormonu (rhGH) verilen anoreksiya nervoza hastalarında IGF-I düzeylerinin arttığı, tiroid hormonlarında düzelme olduğu, termogenezde iyileşme sonucu vücut ısısında düzelme olduğu, kan glukoz düzeylerinde artış olduğu ve sonuç olarak da, vücut ağırlığında düzelme olduğu gösterilmiştir. [51] …”

Section: Merkezi Nöropeptid Sistemleriunclassified

Neuroendocrine and Molecular Interactions in Eating Disorders

Zincir¹

2014

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖzetYeme bozukluklarının gelişiminde üç temel ayağın bulunduğu söylenebilir: genetik yatkınlık, beyindeki nöroendokrin-moleküler değişimler ve metabolizmanın buna yanıtı. Nöroendokrin araştırmalar sonucunda nöroendokrin işlevler ile yeme bozuklukları ve duygudurum bozuklukları gibi psikiyatrik hastalıkların belirti kümeleri arasında yakın bir ilişki olduğu saptanmıştır. Yeme bozukluklarının temelinde etkisi olduğu varsayılan bazı hormonlar, nörotransmitterler ve diğer moleküller östrojen, serotonin, leptin, ghrelin, alfa-melanosit uyarıcı hormon, kolesistokinin, dopamin, noradrenalin, beyin kaynaklı nörotrofik faktör, agouti-ilişkili protein, nöropeptid-Y, opioidler ve reseptörleri, tiyamin, çinko, omega-3 yağ asitleridir. Bu derlemede yeme bozukluklarında ortaya çıkan ana nöroendokrin-moleküler değişimler ve etkileşimler ele alınmıştır.Anahtar sözcükler: Yeme bozuklukları, anoreksiya nervoza, nöroendokrin işlevler. AbstractThere are three basic pillars for the development of eating disorders: genetic predisposition, neuroendocrine-molecular changes in the brain and metabolic response to it. As a result of neuroendocrine research, a close relationship has been found between neuroendocrine functions and symptom domains of psychiatric disorders such as eating disorders and mood disorders. Certain hormones, neurotransmitters and other molecules which might have effect on the basis of eating disorders can be listed as estrogen, serotonin, leptin, ghreline, alpha-melanocyte stimulating hormone, cholecystokinin, dopamine, noradrenaline, brain-derived neurotropic factor, agoutirelated protein, neuropeptide-Y, opioids and their receptors, thiamine, zinc, omega-3 acids. In this review, main neuroendocrine-molecular changes and interactions that occur in the eating disorders have been discussed.

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“…Rekombinant insan büyüme hormonu (rhGH) verilen AN hastalarında IGF-I düzeylerinin arttığı, tiroid hormonlarında düzelme olduğu, termogenezde iyileş-me sonucu vücut ısısında düzelme olduğu, kan glukoz düzeylerinde artış olduğu ve sonuç olarak da, vücut ağırlığında düzelme olduğu gösterilmiştir (24). …”

Section: Büyüme Hormonu Salınımındaki Değişimunclassified

Anoreksiya nervozada hormonal değişimler / Endocrinological changes in anorexia nervosa

Annagür¹,

Zincir²

2012

Dusunen Adam

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Endocrinological changes in anorexia nervosaAnorexia nervosa is an eating disorder that begins between the ages of 12 to18 and characterized by conscious trials of being excessively thin because of weight gain fears. Anorexia nervosa is mostly seen in girls and lifetime prevalence among young women is approximately 0.3%. It is suggested that endocrinological changes seen in anorexia nervosa are not due to primary endocrinological disorders and that they are usually common consequences of long duration fasting and excessive weight loss. There are several serious negative effects of loosing weight and long duration fasting on the organ systems. Anorexia nervosa has a high mortality rate due to the metabolic effects that can reach dangerous levels although the disease may become chronic. In this review, endocrinological changes and their interactions in anorexia nervosa are evaluated.

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Administration of Recombinant Human Growth Hormone Normalizes GH-IGF1 Axis and Improves Malnutrition-related Disorders in Patients with Anorexia Nervosa

Cited by 19 publications

References 28 publications

Impaired insulin secretion and decreased expression of the nutritionally responsive ribosomal kinase protein S6K-1 in pancreatic islets from malnourished rats

Impaired insulin secretion and decreased expression of the nutritionally responsive ribosomal kinase protein S6K-1 in pancreatic islets from malnourished rats

Neuroendocrine and Molecular Interactions in Eating Disorders

Anoreksiya nervozada hormonal değişimler / Endocrinological changes in anorexia nervosa

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