Administration of Porphyromonas Gingivalis in Pregnant Mice Enhances Glycolysis and Histone Lactylation/ADAM17 Leading to Cleft Palate in Offspring
Juan Du,
Xige Zhao,
Xiaoyu Zheng
et al.
Abstract:Periodontal disease is a risk factor for many systemic diseases such as Alzheimer’s disease and adverse pregnancy outcomes. Cleft palate (CP), the most common congenital craniofacial defect, has a multifaceted etiology influenced by complex genetic and environmental risk factors such as maternal bacterial or virus infection. A prior case-control study revealed a surprisingly strong association between maternal periodontal disease and CP in offspring. However, the precise relationship remains unclear. In this s… Show more
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