Administration of noradrenaline in the autonomic ganglia modifies the testosterone release from the testis using an ex vivo system

Sosa, Zulema; Palmada, Miguel N.; Fóscolo, M.R.; Capani, Francisco; Conill, Alberto; Cavicchia, Juan C.

doi:10.1111/j.1365-2605.2008.00927.x

Cited by 10 publications

(2 citation statements)

References 49 publications

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“…[ 1 ] The SSN fibers emanate from the superior mesenteric ganglion coupled with inputs from renal, spermatic, and aortic plexuses and descend bilaterally to approach the testes in the company of testicular artery and gain entrance into the testis at the cranial pole. [ 2 3 4 ] The SSN can also receive afferent and possibly vagal parasympathetic fibers, whereas the ISN fibers carry mostly sympathetic fibers. It originates from the inferior mesenteric ganglion and pelvic plexus accompanied by the vas deferens and then gain access to the caudal pole of the testes through the inferior ligament of the tail of epididymis.…”

Section: Introductionmentioning

confidence: 99%

Nerve and Glial Cell Expressions in the Testes and Epididymides of Different Age Groups of Cane Rat (Thryonomys swinderianus)

Omirinde

Olukole

Oke

2021

Journal of Microscopy and Ultrastructure

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Purpose: This study was conducted to examine the variations in the expressions of neuronal and glial cell markers in the testes and epididymides of different age groups of cane rat using histochemical and immunohistochemical techniques. Method: Thirty (32) healthy domesticated male cane rats were used for this investigation. The rats were divided into four groups (prepubertal [≤4 months], pubertal (>4 ≤12 months), adult (>12 ≤30 months), and aged (>30 months)] of 8 animals each. Subsequent to anesthesia and intracardiac perfusion of the rats with 10% buffered formalin, testes were harvested and preliminary assessment of nervous and glial structures was determined using the Golgi technique. Specific immunolocalization was done using the anti-neurofilament (NF-20) and anti-glial fibrillary acid protein (GFAP) for the expressions of neuronal and astrocyte-like cells, respectively. Result: Neuronal and astrocyte-like structures as revealed by the Golgi procedure were demonstrated in the tunica albuginea and interstitium of the testes as well as in the periductal muscle coat and epididymal interstitium of the caput down to the caudal segments. Golgi signal intensities of the expressions in both testes and epididymides increased with age advancement. Immunolocalization of the nerve structures and glial cells tallied with the Golgi results. However, NF signal intensity was significantly higher in the adult relative to others. Similarly, GFAP signal intensity increased with age increment. Conclusion: This study has shown that the variation in the expression of neuronal and glial cells in the testis and epididymis of the cane rat could be associated with increased reproductive reproductive activity.

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Section: Introductionmentioning

confidence: 99%

Nerve and Glial Cell Expressions in the Testes and Epididymides of Different Age Groups of Cane Rat (Thryonomys swinderianus)

Omirinde

Olukole

Oke

2021

Journal of Microscopy and Ultrastructure

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“…The superior spermatic nerve (SSN) fiber chiefly derived its fibers from the cranial mesenteric ganglion together with inputs from the renal and aortic plexuses and, thereafter, continues to meet the testis along with testicular artery to penetrate the testis at the cranial pole ( 10 ). The SSN receives both the afferent and vagal parasympathetic fibers, while the inferior spermatic nerve (ISN) fibers are predominantly sympathetic ( 11 , 12 ).…”

Section: Autonomic Innervation Of the Mammalian Male Genitaliamentioning

confidence: 99%

Neuropeptide Profiles of Mammalian Male Genital Tract: Distribution and Functional Relevance in Reproduction

Omirinde

Azeez

2022

Front. Vet. Sci.

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Neuropeptides are secretory peptides characterized by small chains of amino acids linked by peptide bonds. They are majorly found in some mammalian neurons and glial cells, where they modulate a variety of physiological homeostasis. In the male genital tract, they are mostly found in the neuronal fibers supplying the vasculature, smooth muscle layer, interstitium, and lamina propria of the tunica mucosa of the various reproductive organs. Functionally, neuropeptides are strongly implicated in vascular temperature regulations, spermatozoa extrusion, epididymal content transportation, and movement of accessory gland secretions. This review provides an overview of neuropeptides with respect to their synthesis, release, and mechanism of actions, with emphasis on the locally acting neuropeptides, such as substance P (SP), neuropeptide Y (NPY), vasoactive intestinal peptides (VIP), calcitonin gene-related peptide (CGRP), galanin (GAL), cholecystokinin (CCK), C-terminal flanking peptide of NPY (CPON), peptide histidine isoleucine (PHI), and met- and leu-enkephalins (M-ENK and L-ENK) along the male genital tract (i.e., the spermatic cord, testis, epididymis, ductus deferens, and accessory sex organs) of 14 species of mammals and their marked influence on reproduction. This review also revealed from documented reports that the vast majority of neuropeptides present in the autonomic nerve supply to the male genital tract probably coexist with other peptides or with various neurotransmitters (tyrosine hydroxylase, dopamine beta hydroxylase, and 5-hydroxytryptamine). In addition, documented evidence of variation in age, season, and intraspecies differences were identified as notable factors of influence in peptidergic nerve fiber distribution.

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Involvement of the mesenteric ganglia on androstenedione, noradrenaline and nitrite release using a testis ex vivo system

et al. 2011

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The autonomic nerve fibres converge to the testis along two major pathways, the superior spermatic nerve (SSN) and the inferior spermatic nerve (ISN). The object of this work was to evaluate whether the addition of noradrenaline (NA) in the ganglionic compartment of two ex vivo systems: superior mesenteric ganglion (SMG)-SSN-testis, inferior mesenteric ganglion (IMG)-ISN-testis modulate androstenedione (A₂), NA and nitrite release and to determine whether there are secretory differences between the right and the left testis. Each gonad with its respective ganglion was transferred into a cuvette with two compartments and incubated in a Dubnoff metabolic shaker. The testis incubation liquids were collected and analysed for NA by HPLC, A₂ by RIA and nitrites by the Griess method. When NA is added to the IMG, A₂ and NA release diminishes and nitrite increases in the left testis, while in the right gonad, A₂ and NA increase and nitrite decreases. When NA was administered to the SMG, A₂ and NA increase and nitrite diminishes in the left gonad, but they show opposite fluctuations in the right testis. These ex vivo systems appear to be excellent models for studying the sympathetic ganglionic control of the testis though A₂, NA and nitrite release from the male gonad. It is evident that a better knowledge about the role of catecholamines and nitric oxide in the testis physiology may facilitate the understanding of some reproductive diseases.

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Administration of noradrenaline in the autonomic ganglia modifies the testosterone release from the testis using an ex vivo system

Cited by 10 publications

References 49 publications

Nerve and Glial Cell Expressions in the Testes and Epididymides of Different Age Groups of Cane Rat (Thryonomys swinderianus)

Nerve and Glial Cell Expressions in the Testes and Epididymides of Different Age Groups of Cane Rat (Thryonomys swinderianus)

Neuropeptide Profiles of Mammalian Male Genital Tract: Distribution and Functional Relevance in Reproduction

Involvement of the mesenteric ganglia on androstenedione, noradrenaline and nitrite release using a testis ex vivo system

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