Administration of lasalocid‐NA is preventive against cryptosporidiosis of newborn calves

Murakoshi, Fumi; Takeuchi, Masashi; Inomata, Atsuko; Horimoto, Taisuke; Ito, Minao; Suzuki, Yoshihisa; Kato, Koichiro

doi:10.1136/vr.102508

Cited by 6 publications

(7 citation statements)

References 8 publications

(9 reference statements)

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Section: Cryptosporidiosismentioning

confidence: 99%

“…Lasalocid acid has been reported to display anti-cryptosporidial activity both in vitro and in experimental-infected animals [190,191]. This includes studies that examined the effectiveness of lasalocid acid as novel agent against cryptosporidiosis in calves [190]. In addition, lasalocid acid was identified in a rat model as that agent that produced the highest anti-cryptosporidial effect among other chemotherapeutics tested [191].…”

Section: Cryptosporidiosismentioning

confidence: 99%

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Anti-parasitic activity of polyether ionophores

Antoszczak

Steverding

Huczyński

2019

European Journal of Medicinal Chemistry

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Despite some progress in recent years, the fight against parasitic diseases still remains a great challenge. Parasitic diseases affect primarily (but not exclusively) the poorest people living in underdeveloped regions of the world. The distribution of parasitoses are linked to tropical and subtropical climate conditions, to population growth and to impoverishment. If not treated, parasitic diseases may lead to serious health problems, and even death. Particularly vulnerable groups include infants and young children, pregnant women and immunocompromised individuals. Polyether ionophore antibiotics (ionophores), traditionally used in veterinary medicine as anti-coccidial feed additives and non-hormonal growth promoters, are of considerable interest, as they have been found to be highly effective agents against various parasites, both in vitro and in vivo. This review summarizes the anti-parasitic effects of the most important polyether ionophores against parasites that are responsible for a number of animal and human parasitic diseases. Recent findings and advances that support the potential of polyether ionophore antibiotics as novel anti-parasitic drug candidates are also presented and discussed.

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Section: Cryptosporidiosismentioning

confidence: 99%

Section: Cryptosporidiosismentioning

confidence: 99%

Anti-parasitic activity of polyether ionophores

Antoszczak

Steverding

Huczyński

2019

European Journal of Medicinal Chemistry

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“…GP60 based subtype can usually be further characterized based on the number of trinucleotide repeats (TCA or TCG) coding for the amino acid serine (Sulaiman et al, 2005). In Japan, IIaA15G2R1 subtype is the only subtype of C. parvum that has been detected to date (Wu et al, 2003;Abe et al, 2006;Murakoshi et al, 2013Murakoshi et al, , 2014Ichikawa-Seki et al, 2014;Aita et al, 2015).…”

mentioning

confidence: 99%

Molecular epidemiological analyses of Cryptosporidium parvum virus 1 (CSpV1), a symbiotic virus of Cryptosporidium parvum, in Japan

et al. 2016

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We show that Cryptosporidium parvum virus 1 (CSpV1), a member of the family Partitiviridae, genus Cryspovirus that can infect Cryptosporidium parvum, is a new candidate for high-resolution tool for tracing C. parvum. CSpV1 was detected in all C. parvum-positive samples tested. Phylogenetic analysis of dsRNA1 sequence from CSpV1 can distinguish infected areas of C. parvum on the national level. Sequences detected in samples from Iwate prefecture and other islands (Tanegashima, and Okinawa) belonged to a single clade. This system can differentiate the samples from Hokkaido and south part of Japan as well as from other countries. Samples from Iwate, Tanegashima, and Okinawa belonged to a single subclade, respectively. Therefore, the CSpV1 dsRNA sequences reflect the regional distribution of their host and have potential as a high-resolution tool to trace C. parvum IIaA15G2R1 subtype.

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“…Furthermore, heparin is known to inhibit the infection of various kinds of pathogen 41 43 47 48 . Most of the existing anti-cryptosporidial medicines are antibiotics or ionophores 6 7 8 9 10 . But these medicines have side effects and there is little information about safe dosages.…”

Section: Discussionmentioning

confidence: 99%

“…Nitazoxanide is only the drug approved by the FDA 7 for the treatment of cryptosporidiosis; it effectively eradicates C. parvum oocysts from stool and resolves the diarrhea of both immuno-competent and -compromised individuals 8 . Lasalocid is an ionophorous antibiotic that reduces oocyst excretion in cattle 9 10 . However, all of these agents have limited effects on parasite growth, highlighting the urgent need for novel effective anti-cryptosporodial drugs.…”

mentioning

confidence: 99%

Heparin interacts with elongation factor 1α of Cryptosporidium parvum and inhibits invasion

Inomata

Murakoshi

Ishiwa

et al. 2015

Sci Rep

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Cryptosporidium parvum is an apicomplexan parasite that can cause serious watery diarrhea, cryptosporidiosis, in human and other mammals. C. parvum invades gastrointestinal epithelial cells, which have abundant glycosaminoglycans on their cell surface. However, little is known about the interaction between C. parvum and glycosaminoglycans. In this study, we assessed the inhibitory effect of sulfated polysaccharides on C. parvum invasion of host cells and identified the parasite ligands that interact with sulfated polysaccharides. Among five sulfated polysaccharides tested, heparin had the highest, dose-dependent inhibitory effect on parasite invasion. Heparan sulfate-deficient cells were less susceptible to C. parvum infection. We further identified 31 parasite proteins that potentially interact with heparin. Of these, we confirmed that C. parvum elongation factor 1α (CpEF1α), which plays a role in C. parvum invasion, binds to heparin and to the surface of HCT-8 cells. Our results further our understanding of the molecular basis of C. parvum infection and will facilitate the development of anti-cryptosporidial agents.

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Administration of lasalocid‐NA is preventive against cryptosporidiosis of newborn calves

Cited by 6 publications

References 8 publications

Anti-parasitic activity of polyether ionophores

Anti-parasitic activity of polyether ionophores

Molecular epidemiological analyses of Cryptosporidium parvum virus 1 (CSpV1), a symbiotic virus of Cryptosporidium parvum, in Japan

Heparin interacts with elongation factor 1α of Cryptosporidium parvum and inhibits invasion

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