Administration of inhaled noble and other gases after cardiopulmonary resuscitation: A systematic review

Alshami, Abbas; Einav, Sharon; Skrifvars, Markus B.; Varon, Joseph

doi:10.1016/j.ajem.2020.06.066

Cited by 8 publications

(6 citation statements)

References 80 publications

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“…These include gas mixtures containing inert gases at low concentrations, nitric oxide (II), hydrogen, and hydrogen sulfide. Xenon, nitric oxide (II), and hydrogen have neuroprotective and cardiotonic properties, while argon and hydrogen sulfide have only neuroprotective properties (Alshami et al, 2020). An important element of the treatment is the elimination of inflammation.…”

Section: Means Of Emergency Ib Protectionmentioning

confidence: 99%

Gut Barrier in Critical States of the Body

Schäfer¹,

Vakunenkova²,

Ivnitsky³

et al. 2022

Biol Bull Rev

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The intestinal barrier (IB) is a system of diffusion barriers separating the intestinal chyme and blood. The aim of the review is to identify the role of IB dysfunction in the formation of critical states of the body and to substantiate ways to prevent these states. Toxic substances produced by normal intestinal microflora are characterized. The involvement of endotoxin and ammonia in the pathogenesis of sepsis, acute circulatory disorders, secondary acute pulmonary lesions, and acute cerebral insufficiency is shown. Approaches to protect the IB in critical states of the body are proposed.

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Section: Means Of Emergency Ib Protectionmentioning

confidence: 99%

Gut Barrier in Critical States of the Body

Schäfer¹,

Vakunenkova²,

Ivnitsky³

et al. 2022

Biol Bull Rev

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“…Clinical trials of oxygen-enriched gas mixtures containing inert gases, nitrogen oxide or hydrogen at low concentrations also show a lot of promise; the properties of these additives can modulate the effects of oxygen therapy. Xenon, nitric oxide and hydrogen have neuroprotective and cardiotonic properties, while argon and hydrogen sulfide have neuroprotective properties only [ 163 ]. Anti-inflammatory drugs can be supplementary to oxygen therapy: in experimental sepsis modeling, both IB dysfunction and endotoxemia were prevented by hydrocortisone administration [ 164 ].…”

Section: Intestinal Barrier Protection In Acute Exogenous Poisoningsmentioning

confidence: 99%

Secondary Dysfunction of the Intestinal Barrier in the Pathogenesis of Complications of Acute Poisoning

Ivnitsky

Schäfer²,

Rejniuk³

et al. 2022

J Evol Biochem Phys

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The last decade has been marked by an exponential increase in the number of publications on the physiological role of the normal human gut microbiota. The idea of a symbiotic relationship between the human organism and normal microbiota of its gastrointestinal tract has been firmly established as an integral part of the current biomedical paradigm. However, the type of this symbiosis varies from mutualism to parasitism and depends on the functional state of the host organism. Damage caused to the organism by external agents can lead to the emergence of conditionally pathogenic properties in the normal gut microbiota, mediated by humoral factors and affecting the outcome of exogenous exposure. Among the substances produced by symbiotic microbiota, there are an indefinite number of compounds with systemic toxicity. Some occur in the intestinal chyme in potentially lethal amounts in the case they enter the bloodstream quickly. The quick entry of potential toxicants is prevented by the intestinal barrier (IB), a set of structural elements separating the intestinal chyme from the blood. Hypothetically, severe damage to the IB caused by exogenous toxicants can trigger a leakage and subsequent systemic redistribution of toxic substances of bacterial origin. Until recently, the impact of such a redistribution on the outcome of acute exogenous poisoning remained outside the view of toxicology. The present review addresses causal relationships between the secondary dysfunction of the IB and complications of acute poisoning. We characterize acute systemic toxicity of such waste products of the normal gut microflora as ammonia and endotoxins, and demonstrate their involvement in the formation of such complications of acute poisoning as shock, sepsis, cerebral insufficiency and secondary lung injuries. The principles of assessing the functional state of the IB and the approaches to its protection in acute poisoning are briefly considered.

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“…Результаты последних исследований органопротективных свойств аргона на различных моделях отражены в работах [44][45][46][47][48]. При этом в ходе исследований обычно были получены либо положительные, либо нейтральные результаты воздействия аргона, что, скорей всего, зависело от его концентрации, длительности и модели эксперимента [49,50].…”

Section: органопротективные свойстваunclassified

Organoprotective Properties of Argon (Review)

Boeva

Гребенчиков

2022

Obŝaâ reanimatologiâ

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The history of studying the organoprotective properties of argon (Ar) began in 1998 when a group of Russian researchers investigated the effect of hypoxic gas mixtures on mammalian organisms. Over several decades, evidence of the cardio-, neuro-, and nephroprotective effects of argon in various diseases and conditions in experimental models in vivo and in vitro have been accumulated. However, the lack of clinical studies to date has prompted us to carry out a systematic review analyzing the results of preclinical studies revealing organoprotective properties of argon, which could provide a rationale for its future clinical studies.The aim of this review is to describe the mechanisms of organoprotective properties of argon determined in preclinical studies.Material and methods. The search yielded 266 articles. The search algorithm was developed in accordance with the requirements and reporting guidelines for systematic reviews and meta-analysis (PRISMA) in the PubMed and Google Scholar databases. The methodology included using search queries, keywords (including MeSH), and logical operators. The keywords used for the search in the PubMed and Google Scholar databases were «argon», «ar», «protection», and «mechanism». The review included in vivo and in vitro studies.Results. The following mechanisms of argon action were identified: activation of N-terminal c-Jun kinase(JNK), p38(ERK1/2), and ERK1/2 in models of airway epithelial cells, neuronal and astroglial cell cultures, as well as in models of retinal ischemia and reperfusion injury in rats and a rabbit model of ischemia-reperfusion myocardium. Significant neuroprotective effects of argon and its influence on apoptosis were shown using small rodent models.Conclusion. The results of preclinical studies of argon have proved both its safety and organoprotective properties in in vitro and in vivo models. Analysis of the data provides a rationale for the initiation of clinical studies of argon, which could significantly improve outcomes in patients after cerebrovascular accidents, particularly post ischemic stroke.

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Administration of inhaled noble and other gases after cardiopulmonary resuscitation: A systematic review

Cited by 8 publications

References 80 publications

Gut Barrier in Critical States of the Body

Gut Barrier in Critical States of the Body

Secondary Dysfunction of the Intestinal Barrier in the Pathogenesis of Complications of Acute Poisoning

Organoprotective Properties of Argon (Review)

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