Administration of Different Doses of Acrylamide Changed the Chemical Coding of Enteric Neurons in the Jejunum in Gilts

Bulc, Michał; Całka, Jarosław; Palus, Katarzyna

doi:10.3390/ijerph192114514

Cited by 2 publications

(4 citation statements)

References 42 publications

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“…In the jejunum, small ACR doses caused the greatest changes in the chemical coding of the myenteric plexus neurons. Increased immunoreactivity with respect to PACAP, CART, CGRP, VAChT, GAL, and SP was observed [86,[92][93][94][95]. The increase in the OSP was significant only in the case of PACAP.…”

Section: Impact Of Acrylamide On the Enteric Nervous Systemmentioning

confidence: 88%

“…When it comes to the ISP, an increase in the number of PACAP-, VIP-, and GAL-IR and a decrease in the nNOS-IR ones were demonstrated. An increase in the population of PACAP-, CART-, CGRP-, VAChT-, VIP-, GAL-, and SP-IR and a decrease in that of nNOS-IR neurons were visible in all the intramural plexuses in the case of a large dose of ACR [86,[92][93][94][95].…”

Section: Impact Of Acrylamide On the Enteric Nervous Systemmentioning

confidence: 94%

“…High dose: an increase in the population of PA-CAP-, CART-, CGRP-, VAChT-, VIP-, GAL-, and SP-immunoreactive and a decrease in that of nNOS-positive neurons in the MP, OSP, and ISP. [86,[92][93][94][95] ileum pig 0.5 and 5 µg/kg of b.w./day for 28 days Low dose: an increase in the number of CART-, CGRP-, VIP-, GAL-, and SP-immunopositive and a decrease in the number of nNOS-positive in the MP; an increase in immunoreactivity with respect to VAChT, VIP, and SP and a decrease in the number of nNOS-immunoreactive neurons in the OSP; increased number of CGRP-, VAChT-, VIP-, and GAL-immunoreactive neurons the ISP. High dose: an increase in the number of PACAP-, CART-, CGRP-, VAChT-, VIP-, GAL-, and SP-immunoreactive and decreased the number of nNOSpositive neurons in the MP, OSP, and ISP.…”

Section: Impact Of Acrylamide On the Enteric Nervous Systemmentioning

confidence: 99%

“…Further studies with a domestic pig model showed that a 4-week supplementation of ACR considerably altered the chemical coding of ENS neurons. The changes depended on the dose and the gastrointestinal tract section under investigation [39,86,[89][90][91][92][93][94][95]. In the stomach, low-dose ACR supplementation corresponding to a tolerable daily intake (TDI) (0.5 µg/kg b.w./day) caused an increase in the population of neurons immunoreactive to galanin (GAL), cocaine-and amphetamine-regulated transcript peptide (CART), vesicular acetylcholine transporter (VAChT), VIP, and SP in submucous plexuses in the corpus.…”

Section: Impact Of Acrylamide On the Enteric Nervous Systemmentioning

confidence: 99%

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Dietary Exposure to Acrylamide Has Negative Effects on the Gastrointestinal Tract: A Review

Palus

2024

Nutrients

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Changing eating habits and an increase in consumption of thermally processed products have increased the risk of the harmful impact of chemical substances in food on consumer health. A 2002 report by the Swedish National Food Administration and scientists at Stockholm University on the formation of acrylamide in food products during frying, baking and grilling contributed to an increase in scientific interest in the subject. Acrylamide is a product of Maillard’s reaction, which is a non-enzymatic chemical reaction between reducing sugars and amino acids that takes place during thermal processing. The research conducted over the past 20 years has shown that consumption of acrylamide-containing products leads to disorders in human and animal organisms. The gastrointestinal tract is a complex regulatory system that determines the transport, grinding, and mixing of food, secretion of digestive juices, blood flow, growth and differentiation of tissues, and their protection. As the main route of acrylamide absorption from food, it is directly exposed to the harmful effects of acrylamide and its metabolite—glycidamide. Despite numerous studies on the effect of acrylamide on the digestive tract, no comprehensive analysis of the impact of this compound on the morphology, innervation, and secretory functions of the digestive system has been made so far. Acrylamide present in food products modifies the intestine morphology and the activity of intestinal enzymes, disrupts enteric nervous system function, affects the gut microbiome, and increases apoptosis, leading to gastrointestinal tract dysfunction. It has also been demonstrated that it interacts with other substances in food in the intestines, which increases its toxicity. This paper summarises the current knowledge of the impact of acrylamide on the gastrointestinal tract, including the enteric nervous system, and refers to strategies aimed at reducing its toxic effect.

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Section: Impact Of Acrylamide On the Enteric Nervous Systemmentioning

confidence: 88%

Section: Impact Of Acrylamide On the Enteric Nervous Systemmentioning

confidence: 94%

Section: Impact Of Acrylamide On the Enteric Nervous Systemmentioning

confidence: 99%

Section: Impact Of Acrylamide On the Enteric Nervous Systemmentioning

confidence: 99%

See 2 more Smart Citations

Dietary Exposure to Acrylamide Has Negative Effects on the Gastrointestinal Tract: A Review

Palus

2024

Nutrients

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Oral Exposure to Microplastics Affects the Neurochemical Plasticity of Reactive Neurons in the Porcine Jejunum

Gałęcka,

Całka

2024

Nutrients

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Plastics are present in almost every aspect of our lives. Polyethylene terephthalate (PET) is commonly used in the food industry. Microparticles can contaminate food and drinks, posing a threat to consumers. The presented study aims to determine the effect of microparticles of PET on the population of neurons positive for selected neurotransmitters in the enteric nervous system of the jejunum and histological structure. An amount of 15 pigs were divided into three groups (control, receiving 0.1 g, and 1 g/day/animal orally). After 28 days, fragments of the jejunum were collected for immunofluorescence and histological examination. The obtained results show that histological changes (injury of the apical parts of the villi, accumulations of cellular debris and mucus, eosinophil infiltration, and hyperaemia) were more pronounced in pigs receiving a higher dose of microparticles. The effect on neuronal nitric oxide synthase-, and substance P-positive neurons, depends on the examined plexus and the dose of microparticles. An increase in the percentage of galanin-positive neurons and a decrease in cocaine and amphetamine-regulated transcript-, vesicular acetylcholine transporter-, and vasoactive intestinal peptide-positive neurons do not show such relationships. The present study shows that microparticles can potentially have neurotoxic and pro-inflammatory effects, but there is a need for further research to determine the mechanism of this process and possible further effects.

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Administration of Different Doses of Acrylamide Changed the Chemical Coding of Enteric Neurons in the Jejunum in Gilts

Cited by 2 publications

References 42 publications

Dietary Exposure to Acrylamide Has Negative Effects on the Gastrointestinal Tract: A Review

Dietary Exposure to Acrylamide Has Negative Effects on the Gastrointestinal Tract: A Review

Oral Exposure to Microplastics Affects the Neurochemical Plasticity of Reactive Neurons in the Porcine Jejunum

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