“…Another critical aspect is that only about three relevant papers on this topic have been published in the last 20 years. On the one hand, this is because the contrast media most commonly used to date (e.g., Telebrix 1972), including the MRI contrast media (e.g., Dotarem 1989) were developed over several decades towards the end of the last century and the corresponding studies on patient safety had to be published between invention and approval [ 23 , 24 , 25 , 26 ]. On the other hand, the importance of image-guided interventions increased with an evident time lag [ 27 ].…”