Administration of branched-chain amino acids alters epigenetic regulatory enzymes in an animal model of Maple Syrup Urine Disease

Streck, Emílio L.; Bussular, Felipe P; Wessler, Leticia B.; Duarte, Mariane Bernardo; Rezende, Victória Linden De; Rodrigues, Matheus Scarpatto; Torres, Carolina A.; Lemos, Isabela S; Candiotto, Gabriela; Gava, Fernanda F.; Oliveira, Jade de; Valvassori, Samira S.

doi:10.1007/s11011-020-00631-1

Cited by 5 publications

(2 citation statements)

References 64 publications

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“…The classification layer of this module completes the final prediction. The input layer accepts the feature vector combined with the three-layer two-way LSTM, and the hidden layer uses the activation function ReLU function to perform the output activation operation [ 18 ]. The output layer uses the Softmax function, which calculates and predicts the size of each probability distribution:

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Section: Muscle Injury Protection Methods Based On Deep Learningmentioning

confidence: 99%

Analysis of the Effect of Branched Chain Amino Acids on Muscle Health Information of Swimmers Based on Multisensor Fusion and Deep Learning

Huang

Luo

Liao

2022

Applied Bionics and Biomechanics

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Swimmers must fully mobilize the muscles of the whole body during exercise, and it is necessary to study the protection of swimmers from muscle damage. Now, muscle damage is increasing year by year, and more athletes are affected. Therefore, studying the causes of muscle injuries and exploring more effective treatments have become important research topics in the field of sports medicine. This study is mainly based on deep learning to analyze the protective effect of branched-chain amino acids on swimming athletes’ muscle injury. Due to the complex and changeable environment and the interference of unknown factors, a single sensor cannot meet the needs of obtaining information. Therefore, people have developed the technology of multisensor information fusion to obtain enough information. Multisensor data fusion technology can synthesize the information of each sensor and then obtain more comprehensive and accurate decision-making information. This study is mainly based on multisensor fusion and deep learning to analyze the impact of branched chain amino acids on Swimmers’ muscle health information. Finally, two experiments were designed in this article. The first experimental result showed that the pain level of the experimental group who took BCAA supplements was 19% lower than that of the control group that did not take the BCAA supplement within three days after exercise. The results of the second experiment show the following: after exercise, the creatine kinase activity value of the experimental group taking BCAA supplement was 4.38 ± 1.45 , and the creatine kinase activity value of the control group taking placebo was 5.42 ± 2.12 . It proves that BBCA can protect muscle damage by reducing the activity of creatine kinase.

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…”

Section: Muscle Injury Protection Methods Based On Deep Learningmentioning

confidence: 99%

Analysis of the Effect of Branched Chain Amino Acids on Muscle Health Information of Swimmers Based on Multisensor Fusion and Deep Learning

Huang

Luo

Liao

2022

Applied Bionics and Biomechanics

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“…Clinically, residual Bckdh activity leads to maple sirup urine disease (MSUD), a hereditary disorder manifested with feeding problems, ketonuria, hypotonia and progressive neurological deterioration. Without early diagnosis and dietary BCAA restriction, the disease terminates in cerebral edema, central respiratory failure and death (Streck et al 2021).…”

Section: Bckdh Modulationmentioning

confidence: 99%

Branched chain amino acids—friend or foe in the control of energy substrate turnover and insulin sensitivity?

Supruniuk

Żebrowska

Chabowski

2021

Critical Reviews in Food Science and Nutrition

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Branched chain amino acids (BCAA) and their derivatives are bioactive molecules with pleiotropic functions in the human body. elevated fasting blood BCAA concentrations are considered as a metabolic hallmark of obesity, insulin resistance, dyslipidaemia, nonalcoholic fatty liver disease, type 2 diabetes and cardiovascular disease. However, since increased BCAA amount is observed both in metabolically healthy and obese subjects, a question whether BCAA are mechanistic drivers of insulin resistance and its morbidities or only markers of metabolic dysregulation, still remains open. The beneficial effects of BCAA on body weight and composition, aerobic capacity, insulin secretion and sensitivity demand high catabolic potential toward amino acids and/or adequate BCAA intake. On the opposite, BCAA-related inhibition of lipogenesis and lipolysis enhancement may preclude impairment in insulin sensitivity. Thereby, the following review addresses various strategies pertaining to the modulation of BCAA catabolism and the possible roles of BCAA in energy homeostasis. we also aim to elucidate mechanisms behind the heterogeneity of ramifications associated with BCAA modulation.

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Disease Models for Rare Genetic Disorders

Kanakarajan,

Selvaraj,

Kaleena

2024

Rare Genetic Disorders

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Administration of branched-chain amino acids alters epigenetic regulatory enzymes in an animal model of Maple Syrup Urine Disease

Cited by 5 publications

References 64 publications

Analysis of the Effect of Branched Chain Amino Acids on Muscle Health Information of Swimmers Based on Multisensor Fusion and Deep Learning

Analysis of the Effect of Branched Chain Amino Acids on Muscle Health Information of Swimmers Based on Multisensor Fusion and Deep Learning

Branched chain amino acids—friend or foe in the control of energy substrate turnover and insulin sensitivity?

Disease Models for Rare Genetic Disorders

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