Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease

Klemenak, Martina; Dolinšek, Jernej; Langerholc, Tomaž; Gioia, Diana Di; Mičetić-Turk, Dušanka

doi:10.1007/s10620-015-3769-7

Cited by 122 publications

(113 citation statements)

References 33 publications

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“…In addition, the two strains in combination showed a great capability of colonizing the gut of healthy children [40]. In relation to CD, a preliminary important outcome obtained from the administration of the described probiotic formulation to CD patients was the reduction of pro-inflammatory cytokine TNF-α in blood samples of CD subjects on a GFD after three months of treatment, as reported in Klemenak et al [23]. …”

Section: Discussionmentioning

confidence: 93%

“…Children with CD, aged between 1 and 19 years, were positive to serologic markers for CD and positive for small bowel biopsy, according to European Society for Paedriatric Gastroenterology Hepatology and Nutrition (ESPGHAN) criteria for CD [22]. More details about patients (Table S1) and inclusion/exclusion criteria of the recruiting process are available in Klemenak et al [23]. The study was registered at (registration number: NCT02244047).…”

Section: Methodsmentioning

confidence: 99%

“…Samples who showed the right DNA quantification level have been sequenced. * Inclusion criteria are summarized in Klemenak et al [23]. ** Analysis was performed at the beginning of the study (T0) and after 3 months of treatment (T1).…”

Section: Figurementioning

confidence: 99%

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Effect of Bifidobacterium breve on the Intestinal Microbiota of Coeliac Children on a Gluten Free Diet: A Pilot Study

et al. 2016

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Coeliac disease (CD) is associated with alterations of the intestinal microbiota. Although several Bifidobacterium strains showed anti-inflammatory activity and prevention of toxic gliadin peptides generation in vitro, few data are available on their efficacy when administered to CD subjects. This study evaluated the effect of administration for three months of a food supplement based on two Bifidobacterium breve strains (B632 and BR03) to restore the gut microbial balance in coeliac children on a gluten free diet (GFD). Microbial DNA was extracted from faeces of 40 coeliac children before and after probiotic or placebo administration and 16 healthy children (Control group). Sequencing of the amplified V3-V4 hypervariable region of 16S rRNA gene as well as qPCR of Bidobacterium spp., Lactobacillus spp., Bacteroides fragilis group Clostridium sensu stricto and enterobacteria were performed. The comparison between CD subjects and Control group revealed an alteration in the intestinal microbial composition of coeliacs mainly characterized by a reduction of the Firmicutes/Bacteroidetes ratio, of Actinobacteria and Euryarchaeota. Regarding the effects of the probiotic, an increase of Actinobacteria was found as well as a re-establishment of the physiological Firmicutes/Bacteroidetes ratio. Therefore, a three-month administration of B. breve strains helps in restoring the healthy percentage of main microbial components.

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Section: Discussionmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

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Effect of Bifidobacterium breve on the Intestinal Microbiota of Coeliac Children on a Gluten Free Diet: A Pilot Study

et al. 2016

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“…breve BR03 and Streptococcus ( S. ) thermophilus FP4), which have previously been reported to have anti-inflammatory effects [12,13,14] and have been known to colonize in different areas of the gastrointestinal tract, on measures of skeletal muscle performance, damage, and tension following a bout of strenuous exercise. …”

Section: Introductionmentioning

confidence: 99%

Probiotic Streptococcus thermophilus FP4 and Bifidobacterium breve BR03 Supplementation Attenuates Performance and Range-of-Motion Decrements Following Muscle Damaging Exercise

Jäger¹,

Purpura²,

Stone

et al. 2016

Nutrients

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Probiotics have immunomodulatory effects. However, little is known about the potential benefit of probiotics on the inflammation subsequent to strenuous exercise. In a double-blind, randomized, placebo controlled, crossover design separated by a 21-day washout, 15 healthy resistance-trained men ingested an encapsulated probiotic Streptococcus (S.) thermophilus FP4 and Bifidobacterium (B.) breve BR03 at 5 bn live cells (AFU) concentration each, or a placebo, daily for 3 weeks prior to muscle-damaging exercise (ClinicalTrials.gov NCT02520583). Isometric strength, muscle soreness, range of motion and girth, and blood interleukin-6 (IL-6) and creatine kinase (CK) concentrations were measured from pre- to 72 h post-exercise. Statistical analysis was via mixed models and magnitude-based inference to the standardized difference. Probiotic supplementation resulted in an overall decrease in circulating IL-6, which was sustained to 48 h post-exercise. In addition, probiotic supplementation likely enhanced isometric average peak torque production at 24 to 72 h into the recovery period following exercise (probiotic–placebo point effect ±90% CI: 24 h, 11% ± 7%; 48 h, 12% ± 18%; 72 h, 8% ± 8%). Probiotics also likely moderately increased resting arm angle at 24 h (2.4% ± 2.0%) and 48 h (1.9% ± 1.9%) following exercise, but effects on soreness and flexed arm angle and CK were unclear. These data suggest that dietary supplementation with probiotic strains S. thermophilus FP4 and B. breve BR03 attenuates performance decrements and muscle tension in the days following muscle-damaging exercise.

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“…Despite no differences in the incidence of gastrointestinal symptoms were reported, our findings suggest that B. longum CECT 7347 could help to restore the intestinal ecosystem of CD patients. To date, two more randomized, double-blind placebo-controlled human intervention trials have been conducted in CD patients (106,107). One of this trials has evaluated the effects of the administration of B. infantis NLS to untreated CD patients independently of the GFD.…”

Section: B Longum Cect 7347 As Potential Probiotic For CDmentioning

confidence: 99%

Influence of intestinal microbiota in celiac disease pathogenesis and risk

Sevilla¹

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Hace constar que:La memoria titulada "Influence of Intestinal Microbiota in Celiac Disease Pathogenesis and Risk" que presenta Marta Olivares Sevilla para optar al grado de Doctor por la Universidad Politécnica de Valencia, ha sido realizada en el del Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC) bajo su dirección y que reúne las condiciones para ser defendida por su autora. Esta Tesis es el resultado de casi 6 años de trabajo en los que he tenido la suerte de conocer a muchísimas personas que forman parte de esta tesis y de mi vida.En primer lugar, me gustaría dar las gracias al programa JAE del CSIC por la concesión de la beca predoctoral que he disfrutado durante estos años.Mi agradecimiento más especial es para Yolanda, por darme esta gran oportunidad y por descubrirme el mundo de las bacterias que viven en nuestro cuerpo. Gracias por tu confianza, cercanía y por estar siempre de buen humor. He aprendido muchísimo contigo y te lo agradeceré siempre.También me gustaría darle las gracias a Moisés, por su tiempo y su dedicación durante mis primeros años. A todos mis compañeros del laboratorio, que han sido y son tantos que no los puedo enumerar, por toda la ayuda, consejos y los innumerables buenos momentos. A Luis Izquierdo por estar siempre disponible para ayudarnos con la estadística. Y en general, a todo el personal del IATA y del SCSIE que, de una u otra manera, también han contribuido a esta tesis.Gracias a Ludmila Tuckova y a Jana Cinova de la Academia de las Ciencias de la República Checa, y a Nina Lin de la Universidad de Michigan, por su bienvenida y atención durante mi estancia en sus laboratorios.En esta tesis también hay mucho trabajo de clínicos y personal de diversos hospitales que han colaborado en la recolección de muestras. En este sentido, Gemma Castillejo del Hospital Universitario de Reus merece una mención especial.Gracias a Guille y todos los chicos de Obsolete Letterpress por ayudarme con la maquetación y la portada de esta tesis.Por último, gracias a mis amigos por las bromas sobre mi trabajo. Y con especial cariño, gracias a mis padres por creer en mí de manera incondicional, y a mi hermana Alicia por sus inteligentes consejos. Agradecimientos 8 9Celiac disease (CD) is a chronic enteropathy triggered by cereal gluten proteins in genetically predisposed individuals. The etiology is strongly associated with the genes of the human leukocyte antigen (HLA) encoding the DQ2/DQ8 molecules. Most CD patients carry this genotype but this is also present in the 40% of the general population and only a small percentage develops the disease. Thus, the HLA-DQ genotype is necessary but not solely responsible for the disease development. Gluten is the main environmental trigger but its intake neither fully explains the onset nor its clinical manifestations. Other environmental factors (e.g. early feeding practices, infections, intestinal microbiota) have been associated with the risk of developing CD.The only treatment for CD patients is the adherence to a gluten free diet (GFD), but ...

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Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease

Abstract: Probiotic intervention with B. breve strains has shown a positive effect on decreasing the production of pro-inflammatory cytokine TNF-α in children with CD on GFD.

Cited by 122 publications

References 33 publications

Effect of Bifidobacterium breve on the Intestinal Microbiota of Coeliac Children on a Gluten Free Diet: A Pilot Study

Effect of Bifidobacterium breve on the Intestinal Microbiota of Coeliac Children on a Gluten Free Diet: A Pilot Study

Probiotic Streptococcus thermophilus FP4 and Bifidobacterium breve BR03 Supplementation Attenuates Performance and Range-of-Motion Decrements Following Muscle Damaging Exercise

Influence of intestinal microbiota in celiac disease pathogenesis and risk

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