Administration of Aspergillus oryzae suppresses DSS-induced colitis

Nomura, Ryo; Tsuzuki, Sho; Kojima, Takaaki; Nagasawa, Mao; Sato, Yusuke; Uefune, Masayoshi; Baba, Yasunori; Hayashi, Toshiya; Nakano, Hideo; Kato, Masashi; Shimizu, Motoyuki

doi:10.1016/j.fochms.2021.100063

Cited by 4 publications

(5 citation statements)

References 41 publications

(57 reference statements)

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“…Although the positive and/or negative effects of ingesting Gal f antigens on the human body are unknown, these Japanese foods are considered healthy and may have immunostimulatory effects and/or improve intestinal flora ( Kitagaki, 2021 ). Indeed, Nomura et al (2021) reported that heat-killed A. oryzae spores and cell wall extracts from A. oryzae spores had a soothing effect on dextran sodium sulfate-induced colitis. It is hoped that the health benefits of habitual Gal f antigen ingestion will be reported in future studies.…”

Section: Discussionmentioning

confidence: 99%

Identification of galactofuranose antigens such as galactomannoproteins and fungal-type galactomannan from the yellow koji fungus (Aspergillus oryzae)

Kadooka

Tanaka²,

Hira³

et al. 2023

Front. Microbiol.

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Filamentous fungi belonging to the genus Aspergillus are known to possess galactomannan in their cell walls. Galactomannan is highly antigenic to humans and has been reported to be involved in the pathogenicity of pathogenic filamentous fungi, such as A. fumigatus, and in immune responses. In this study, we aimed to confirm the presence of D-galactofuranose-containing glycans and to clarify the biosynthesis of D-galactofuranose-containing glycans in Aspergillus oryzae, a yellow koji fungus. We found that the galactofuranose antigen is also present in A. oryzae. Deletion of ugmA, which encodes UDP-galactopyranose mutase in A. oryzae, suppressed mycelial elongation, suggesting that D-galactofuranose-containing glycans play an important role in cell wall integrity in A. oryzae. Proton nuclear magnetic resonance spectrometry revealed that the galactofuranose-containing sugar chain was deficient and that core mannan backbone structures were present in ΔugmA A. oryzae, indicating the presence of fungal-type galactomannan in the cell wall fraction of A. oryzae. The findings of this study provide new insights into the cell wall structure of A. oryzae, which is essential for the production of fermented foods in Japan.

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Section: Discussionmentioning

confidence: 99%

Identification of galactofuranose antigens such as galactomannoproteins and fungal-type galactomannan from the yellow koji fungus (Aspergillus oryzae)

Kadooka

Tanaka²,

Hira³

et al. 2023

Front. Microbiol.

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“…Furthermore, A. oryzae exhibits robust capabilities in the degradation of various organic matter and plays a pivotal role in the biocycle. In conclusion, A. oryzae proves to be an ideal strain for establishing biofactories that produce industrial enzymes, enabling its significant contribution to the fields of medicine, environment, and food production [7][8][9].…”

Section: Introductionmentioning

confidence: 97%

Aspergillus oryzae as a Cell Factory: Research and Applications in Industrial Production

Sun,

Wu,

Long

et al. 2024

JoF

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Aspergillus oryzae, a biosafe strain widely utilized in bioproduction and fermentation technology, exhibits a robust hydrolytic enzyme secretion system. Therefore, it is frequently employed as a cell factory for industrial enzyme production. Moreover, A. oryzae has the ability to synthesize various secondary metabolites, such as kojic acid and L-malic acid. Nevertheless, the complex secretion system and protein expression regulation mechanism of A. oryzae pose challenges for expressing numerous heterologous products. By leveraging synthetic biology and novel genetic engineering techniques, A. oryzae has emerged as an ideal candidate for constructing cell factories. In this review, we provide an overview of the latest advancements in the application of A. oryzae-based cell factories in industrial production. These studies suggest that metabolic engineering and optimization of protein expression regulation are key elements in realizing the widespread industrial application of A. oryzae cell factories. It is anticipated that this review will pave the way for more effective approaches and research avenues in the future implementation of A. oryzae cell factories in industrial production.

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“…41,42 Aspergillus oryzae and experimental colitis Ryo Nomura et al studied the prebiotic properties of Aspergillus oryzae in mice with dextran sodium sulfate (DSS)-induced damage of colon tissues. 43 16S rRNA gene sequencing of the gut microbiota revealed that the relative abundance of an antiinflammatory Bifidobacterium pseudolongum strain increased 2.0-fold over the control when heat-killed A. oryzae spores were administered during the first stage of the study. In addition, a decrease in the number of Erysipelotrichaceae was revealed, including the Allobaculum genus.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, a decrease in the number of Erysipelotrichaceae was revealed, including the Allobaculum genus. 43 During the second stage of the investigation, it was revealed that besides the heat-killed Aspergillus oryzae spores, cell wall polysaccharides extracted from them also effectively mitigate colon tissue damage and superiorly enhance the growth of anti-inflammatory Bifidobacterium pseudolongum. 43 Aspergillus oryzae and human antibodies A study by Hung Hiep Huynh et al demonstrated that Aspergillus oryzae might be a low-cost substrate for industrial-producing human antibodies.…”

Section: Introductionmentioning

confidence: 99%

“…43 During the second stage of the investigation, it was revealed that besides the heat-killed Aspergillus oryzae spores, cell wall polysaccharides extracted from them also effectively mitigate colon tissue damage and superiorly enhance the growth of anti-inflammatory Bifidobacterium pseudolongum. 43 Aspergillus oryzae and human antibodies A study by Hung Hiep Huynh et al demonstrated that Aspergillus oryzae might be a low-cost substrate for industrial-producing human antibodies. 44 Recombinant monoclonal antibodies are typically produced using mammalian cell lines, such as Chinese hamster ovaries (CHO) cells.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Perspectives of Domesticated Koji Mold - Probiotic Properties of Aspergillus oryzae: A Review Article

Chelidze,

Chelidze

2024

Georgian Biomedical News

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Aspergillus oryzae, known as "Koji-kin" or "Koji mold," has been an indispensable organic part of traditional Japanese cuisine for over a thousand years. Due to its diverse metabolic activity, this filament fungus has distinctive characteristics uncovered via studies conducted over the past two decades. Cumulated shreds of evidence indicate that the unique substances produced by Koji mold have a curative effect on chronic inflammation, metabolic disorders (dyslipidemia, diabetes), cardiovascular and dermatologic diseases, cancer, COVID-19, etc. This article considered the prospects for using Aspergillus oryzae and its derivatives/metabolites in clinical practice as multipurpose preventive and therapeutic agents. Keywords: Aspergillus orizae; Koji-kin; Koji mold; metabolites. REVIEW Metabolites of Aspergillus oryzaeClinical perspectives of Aspergillus oryzae are based on the wide specter of its metabolic activity. This section will discuss the basic properties of certain substances with potential medical properties.The complex effect of following active metabolites mediates the prebiotic properties of Koji-kin:• Acid proteases stimulate the growth of the essential representatives of healthy gut microbiota -bifidobacteria and lactobacilli; 7,8 • Bifidobacterium-stimulating peptides, such as glutamate, serine,

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Administration of Aspergillus oryzae suppresses DSS-induced colitis

Cited by 4 publications

References 41 publications

Identification of galactofuranose antigens such as galactomannoproteins and fungal-type galactomannan from the yellow koji fungus (Aspergillus oryzae)

Identification of galactofuranose antigens such as galactomannoproteins and fungal-type galactomannan from the yellow koji fungus (Aspergillus oryzae)

Aspergillus oryzae as a Cell Factory: Research and Applications in Industrial Production

Clinical Perspectives of Domesticated Koji Mold - Probiotic Properties of Aspergillus oryzae: A Review Article

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