Administration of an Intravenous Fat Emulsion Enriched with Medium-Chain Triglyceride/ω-3 Fatty Acids is Beneficial Towards Anti-Inflammatory Related Fatty Acid Profile in Preterm Neonates: A Randomized, Double-Blind Clinical Trial

Παπανδρέου, Πάνος; Gioxari, Aristea; Ntountaniotis, Dimitrios; Korda, Olga-Natalia; Skouroliakou, Maria; Siahanidou, Tania

doi:10.3390/nu12113526

Cited by 9 publications

(6 citation statements)

References 44 publications

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“…Also, the balance between metabolites of n-3 and n-6 PUFAs seems to be important in pregnancy maintenance and have a significant role in cervical dilatation and initiation of labour [ 32 ]. In randomized, double-blind clinical trials carried out in preterm neonates, the administration of medium-chain triglyceride/n-3 PUFA-enriched intravenous fat emulsion changed the fatty acid profile consistent with an attenuated inflammatory response [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life: A Comparative Study with Infants at Term

et al. 2022

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An observational comparative study was designed to assess the fatty acids profile in erythrocyte membrane phospholipids of 30 preterm neonates (<32 weeks gestation) at birth and after 1 month of life versus a convenience sample of 10 infants born at term. The panel of fatty acids included the families and components of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and n-6 and n-3 polyunsaturated fatty acids (PUFAs) as well as enzyme activity indexes and fatty acids ratios. At birth, the comparison of fatty acid families between preterm and term neonates showed a significantly higher content of SFAs and n-6 PUFAs, and a significantly lower content of MUFAs and n-3 PUFAs in the preterm group. After 30 days of life, significantly higher levels of n-6 PUFAs and significantly lower levels of n-3 PUFAs among preterm neonates persisted. At 30 days of birth, n-6 PUFA/n-3 PUFA and arachidonic acid (ARA) ARA/DHA remained significantly elevated, and DHA sufficiency index significantly decreased in the preterm group. The pattern of n-3 PUFA deficiency at birth and sustained for the first month of life would support the need of milk banking fortified with DHA and the use of DHA supplementation in breastfeeding mothers.

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Section: Discussionmentioning

confidence: 99%

Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life: A Comparative Study with Infants at Term

et al. 2022

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“…In this study, there was no significant difference in the daily dose of ursodiol According to the literature, giving preterm neonates fish oil-containing ILEs is linked to reduced inflammatory response. 18 In addition to reducing the supply of potentially oxidative, inflammatory/immunosuppressive, and prothrombotic ω-6 fatty acids, the incorporation of fish oil also brings about biological effects and appears to decrease the risk of infections and the duration of hospital or intensive care unit stay. 10,[19][20][21] Eicosapentaenoic acid and docosahexaenoic acid, as direct precursors of powerful specialized proresolving mediators, possess favorable bioactivities with established mechanisms of action.…”

Section: Discussionmentioning

confidence: 99%

“…According to the literature, giving preterm neonates fish oil–containing ILEs is linked to reduced inflammatory response 18 . In addition to reducing the supply of potentially oxidative, inflammatory/immunosuppressive, and prothrombotic ω‐6 fatty acids, the incorporation of fish oil also brings about biological effects and appears to decrease the risk of infections and the duration of hospital or intensive care unit stay 10,19–21 .…”

Section: Discussionmentioning

confidence: 99%

Association between two different lipid injectable emulsions and parenteral nutrition–associated cholestasis in very low birth weight infants: A retrospective cohort study

Li,

Chen,

et al. 2024

J Parenter Enteral Nutr

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BackgroundUsing soybean oil‐based lipid emulsions (Intralipid), which contain higher amounts of omega‐6 fatty acids and phytosterols in parenteral nutrition, is a risk factor for cholestasis (PNAC). An alternative form of a mixed lipid emulsion (SMOFlipid) has been developed to reduce the risk of PNAC, but significant benefits over Intralipid in very low birth weight (VLBW) infants have yet to be demonstrated. The aim of this study was to compare the differences in PNAC incidence in VLBW receiving SMOFlipid vs. Intralipid.MethodsThe study was conducted in Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, China, from January 2016 to March 2022. In total, 235 VLBW infants were administered SMOFlipid or Intralipid for ≥ 21 days and were included in the study. The primary outcome was the incidence of PNAC. Secondary outcomes included bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, late‐onset sepsis, length of stay, weight 28 days after birth, severity of PNAC and the time to reversal of PNAC.ResultsForty‐four VLBW infants (35.5%) in the SMOFlipid group vs. 41 (36.9%) in the Intralipid group achieved PNAC (P = 0.817). The subgroup analysis showed that the peak direct bilirubin level was lower (median [IQR] 55.6 [36.4] vs. 118.4 [77.2] μmol/L, P < 0.001) and the time to reversal of PNAC was shorter (median [IQR] 44 [49] vs. 96 [61]; P < 0.001) in the SMOFlipid group than in the Intralipid group.ConclusionsSMOFlipid may represent a better alternative for VLBW infants who require prolonged parenteral nutrition.This article is protected by copyright. All rights reserved.

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“…The ratios ω-6 and ω-3 should be between 2:1 and 4:1, and some health teachers advocate even lower ratios. Studies have shown that a 2-3: 1 ratio between ω-6 and ω-3 helps reduce inflammation in patients with rheumatoid arthritis, a ratio of 5: 1 has a beneficial effect on asthma patients, and the ratio is 10: 1 Has a negative effect: the ratio 2.5: 1 has a reduced effect on the proliferation of rectal cells in patients with colorectal cancer, but the ratio 4: 1 has no effect (Papandreou et al, 2020;Zong et al, 2021).…”

Section: Literature Reviewmentioning

confidence: 99%

Effects of ω-3 fatty acids and ratio of ω-3/ω-6 for health promotion and disease prevention

Мухаметов¹,

YERBULEKOVA²,

AITKHOZHAYEVA³

et al. 2022

Food Sci. Technol

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Awareness of the role of essential fatty acids in human health and disease prevention has been increasing among the population over the past decades. It is known that the positive correlation of essential fatty acid content with a decrease in cardiovascular morbidity and mortality, infant development, brain and vision functioning, arthritis, hypertension, diabetes mellitus, and neurological/neuropsychiatric disorders. Rich sources of essential fatty acids are fish, fish oil, and some vegetable oils. In this paper, the average content of linoleic and α-linolenic acids in oils (g/100 g of fat) and their ratio is presented. In Kazakhstan, among vegetable oils, sunflower oil is the most commonly consumed, in which the ratio ω-6 to ω-3 on average is about 220:1, which exceeds all recommended norms. Based on the examination of literary data on this topic, the desk-based research approach was used in this paper. According to the results, statistical data on the number of diseases of the cardiovascular system and diabetes mellitus are confirmed by studies on the positive relationship between PUWC and the development of these diseases, which indicates the need to conduct more studies on the ratio of ω-6 to ω-3 in the diets. The objective of this research is to encourage scientists to increase their basic grasp of biochemistry in order to improve health and prevent fatty acid illness.

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Administration of an Intravenous Fat Emulsion Enriched with Medium-Chain Triglyceride/ω-3 Fatty Acids is Beneficial Towards Anti-Inflammatory Related Fatty Acid Profile in Preterm Neonates: A Randomized, Double-Blind Clinical Trial

Cited by 9 publications

References 44 publications

Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life: A Comparative Study with Infants at Term

Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life: A Comparative Study with Infants at Term

Association between two different lipid injectable emulsions and parenteral nutrition–associated cholestasis in very low birth weight infants: A retrospective cohort study

Effects of ω-3 fatty acids and ratio of ω-3/ω-6 for health promotion and disease prevention

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