Administration of a β-glucan-enriched extract activates beneficial hepatic antioxidant and anti-inflammatory mechanisms in streptozotocin-induced diabetic rats

Uskoković, Aleksandra; Mihailović, Mirjana; Dinić, Svetlana; Jovanović, Jelena Arambašić; Grdović, Nevena; Marković, Jelena; Poznanović, Goran; Vidaković, Melita

doi:10.1016/j.jff.2013.09.018

Cited by 24 publications

(20 citation statements)

References 38 publications

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“…Our results were in agreement with those of Uskoković et al (2013), who showed that a β-glucan-enriched extract can suppress fasting blood glucose and GlyHb concentrations in STZinduced diabetic rats. TDF, SDF and IDF could be fermented to generate different SCFAs that enhance GLUT-4 via the PPARγ, thus blunting the postprandial glycaemic response (Galisteo et al, 2010).…”

Section: Effects Of Sdf and Idf On Glucose Control Of Nondiabetic Andsupporting

confidence: 93%

“…Our results are in agreement with those of Uskoković et al (2013), who showed downregulation of TNF-α and upregulation of IL-4 in β-glucanenriched extracts, indicating suppression of inflammatory processes. Increased butyrate, produced during the fermentation process in the intestine and colon by DF, especially SDF, is regarded as the mechanism underlying the anti-inflammatory effects of DF (Zapolska-Downar, Siennicka, Kaczmarczyk, Kołodziej, & Naruszewicz, 2004).…”

Section: Effects Of Sdf and Idf On Inflammatory Response In Non-diabesupporting

confidence: 93%

“…A number of clinical trials support the anti-inflammatory role of butyrate in pathologies, such as inflammatory bowel disease (Segain et al, 2000). Furthermore, suppression of inflammatory factors could prevent hepatocellular damage, alleviate oxidative stress and ameliorate hyperglycaemia by blunting the receptor for advanced glycation end products-nuclear factor kappa (RAGE/NF-κB) signalling pathway (Gao, 2005;Mihailović et al, 2013;Uskoković et al, 2013).…”

Section: Effects Of Sdf and Idf On Inflammatory Response In Non-diabementioning

confidence: 99%

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Anti-diabetic effects of soluble and insoluble dietary fibre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats

2016

Journal of Functional Foods

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Section: Effects Of Sdf and Idf On Glucose Control Of Nondiabetic Andsupporting

confidence: 93%

Section: Effects Of Sdf and Idf On Inflammatory Response In Non-diabesupporting

confidence: 93%

Section: Effects Of Sdf and Idf On Inflammatory Response In Non-diabementioning

confidence: 99%

See 1 more Smart Citation

Anti-diabetic effects of soluble and insoluble dietary fibre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats

2016

Journal of Functional Foods

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“…Antioxidant and anti-inflammatory agents play a crucial role against paracetamol intoxication by scavenging active oxygen and free radicals and neutralizing lipid peroxides (YOUSEF et al, 2010). Among several proposed mechanisms of protective effects of β-glucan, the major one is related to its antioxidant capacity (HAVRLENTOVA et al, 2011;USKOKOVIĆ et al, 2013). Vitamin C is naturally occurring free radical scavenger and can protect biomembranes against peroxidative damage.…”

Section: Oxidative Stress Parametersmentioning

confidence: 99%

“…Glucans are glucose polymers found in plants, fungi and some bacterial species, and currently are well-established and powerful immunomodulators with beneficial properties in cancer therapy (HAVRLENTOVA et al, 2011). The significant role of glucans in infection immunity, stress reduction and restoration of damaged bone marrow has already been established (USKOKOVIĆ et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Paracetamol-induced changes of haematobiochemical and oxidative stress parameters in rat blood: Protective role of vitamin C and β-glucan

Matić¹,

Milošević²,

Paunović³

et al. 2016

Kragujevac J Sci

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ABSTRACT. Paracetamol (acetaminophen) is widely used as an over-the-counter analgesic and antipyretic drug. The aim of this study was to investigate the possible protective effects of vitamin C (100mg/kg/day i.p.) and β-glucan (40 mg/kg/day i.p.) on altered haematological, biochemical and oxidative stress parameters in the blood of rats treated with paracetamol (100 mg/kg/day i.p.) for 3 days. Exposure of rats to paracetamol caused changes of some haematological parameters (RBCs count, Hb concentration, Ht value and WBCs count), suggesting that the paracetamol induced haematotoxicity. Paracetamol reduced serum total protein (TP), albumin and globulin, while increased alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities compared to the control. The results indicate that paracetamol is led to significant decrease in the concentration of Na + and K + and increase of Ca 2+ in the serum compared to the control. Coadministration of vitamin C and β-glucan with paracetamol reversed these changes of haematological and biochemical parameters and diminished the toxic effects of paracetamol. The obtained results indicated that the concentration of LPO in erythrocytes significantly increased in, while the concentration of GSH significantly decreased in the group treated with paracetamol compared to control group. Coadministration of vitamin C and β-glucan with paracetamol reversed paracetamol-induced alterations in these oxidative stress parameters. This study suggests that paracetamol has significant prooxidative effects and may disrupt oxidant/antioxidant balance in erythrocytes. Furthermore, coadministration with vitamin C and β-glucan have protective effects on paracetamol-induced oxidative damage and haematotoxicity.

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Stabilization of conjugated linoleic acid via complexation with arabinogalactan and β‐glucan

Veverka

Dubaj

Jorı́k

et al. 2017

Euro J Lipid Sci & Tech

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Conjugated linoleic acid (CLA) was stabilized via its complexation with arabinogalactan or beta‐glucan by freeze‐drying. The complexes were characterized by infrared spectroscopy, X‐ray diffraction, differential scanning calorimetry, and scanning electron microscopy. The results have shown that only a fraction of CLA is present in the form of inclusion complex while the rest is adsorbed on the surface of the polysaccharide matrix. Even though the materials prepared contain relatively high amount of uncomplexed CLA, the complexation yields products with significantly increased stability toward thermal and oxidative stress compared to pristine CLA. Practical applications: The results demonstrate that it is possible to integrate dietary fibre and dietary fat into a single solid functional food material with increased shelf life. Moreover, the combination of CLA with polysaccharide matrix allows preparation of stable O/W emulsions of CLA. Interaction between polysaccharides (beta‐glucan and arabinogalactan) and CLA allows preparation of materials with high CLA loading of up to 30% while maintaining improved oxidative stability compared to free CLA or physical mixture.

show abstract

Administration of a β-glucan-enriched extract activates beneficial hepatic antioxidant and anti-inflammatory mechanisms in streptozotocin-induced diabetic rats

Cited by 24 publications

References 38 publications

Anti-diabetic effects of soluble and insoluble dietary fibre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats

Anti-diabetic effects of soluble and insoluble dietary fibre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats

Paracetamol-induced changes of haematobiochemical and oxidative stress parameters in rat blood: Protective role of vitamin C and β-glucan

Stabilization of conjugated linoleic acid via complexation with arabinogalactan and β‐glucan

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