Archives of Otolaryngology - Head and Neck Surgery
 1992
DOI: 10.1001/archotol.1992.01880050080019
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Administration of a Prostaglandin Synthetase Inhibitor Associated With an Increased Immune Cell Infiltrate in Squamous Cell Carcinoma of the Head and Neck

D. S. Cross1,
Jeffrey L. Platt
2
,
Steven K. Juhn3
et al.
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Cited by 33 publications

(19 citation statements)
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“…Since both processes are pivotal for efficient tumor cell elimination, this may describe a new strategy of tumoral escape from immune responses. Impaired leukocyte migration due to PGE 2 -mediated downregulation of CCR5 may also explain why administration of NSAIDs increases the number of immune cells in the tumor bed in patients with head and neck cancer (39). Down-regulation of CCR5 and Mac-1 was not due to toxic factors in tumor cell supernatants, since viability and MHC class I and CD86 expression levels were not affected and CD80 was only marginally affected (not shown).…”
Section: Discussionmentioning
confidence: 96%
“…As demonstrated in a recent study, the number of immune cells in the tumor infiltrate is increased after administration of indomethacin (39). Since adhesion to the endothelium is another pivotal step for leukocytes in order to leave the bloodstream, we investigated whether Tu-SN also inhibit the function of the ␤2-integrin Mac-1 on monocytes.…”
Section: Tu-sn Down-regulate Adhesion Molecules On Monocytes and Inhimentioning
confidence: 88%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Since both processes are pivotal for efficient tumor cell elimination, this may describe a new strategy of tumoral escape from immune responses. Impaired leukocyte migration due to PGE 2 -mediated downregulation of CCR5 may also explain why administration of NSAIDs increases the number of immune cells in the tumor bed in patients with head and neck cancer (39). Down-regulation of CCR5 and Mac-1 was not due to toxic factors in tumor cell supernatants, since viability and MHC class I and CD86 expression levels were not affected and CD80 was only marginally affected (not shown).…”
Section: Discussionmentioning
confidence: 96%
“…As demonstrated in a recent study, the number of immune cells in the tumor infiltrate is increased after administration of indomethacin (39). Since adhesion to the endothelium is another pivotal step for leukocytes in order to leave the bloodstream, we investigated whether Tu-SN also inhibit the function of the ␤2-integrin Mac-1 on monocytes.…”
Section: Tu-sn Down-regulate Adhesion Molecules On Monocytes and Inhimentioning
confidence: 88%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The peptide P15‐E has also been detected in HNSCC 110,111 . P15‐E is an immunosuppressive murine retroviral peptide important in retroviral pathogenesis.…”
Section: Discussionmentioning
confidence: 98%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In patients with oral squamous cell carcinoma, treatment with indomethacin improved immune function and increased immune infiltrate into tumors. 46 Indomethacin was also found to improve T-cell cell responses to antigen stimulation in patient with melanoma or lung cancer. 47,48 Studies by Lang et al, have shown that use of the selective Cox-2 inhibitor, Rofecoxib, improved monocyte migration and function to levels seen in healthy controls.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.