1992
DOI: 10.1001/archotol.1992.01880050080019
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Administration of a Prostaglandin Synthetase Inhibitor Associated With an Increased Immune Cell Infiltrate in Squamous Cell Carcinoma of the Head and Neck

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Cited by 30 publications
(19 citation statements)
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“…Indomethacin administration is associated with an increased immune cell infiltration in squamous cell carci¬ noma of the head and neck, suggesting that the inhibition of prostaglandin E2 may contribute to the homing ofmononuclear cells to the tumor. 19 Use of sunscreens3,20 and adherence to a diet low in fatty acids21 can help prevent actinic kératoses. How¬ ever, for existing lesions, 3% diclofenac in a 2.5% hyal¬ uronic acid gel shows promise as another topical agent for the treatment of active keratosis, and our findings sug¬ gest that a double-blind randomized study is warranted.…”
Section: Provocative Use Testmentioning
confidence: 99%
“…Indomethacin administration is associated with an increased immune cell infiltration in squamous cell carci¬ noma of the head and neck, suggesting that the inhibition of prostaglandin E2 may contribute to the homing ofmononuclear cells to the tumor. 19 Use of sunscreens3,20 and adherence to a diet low in fatty acids21 can help prevent actinic kératoses. How¬ ever, for existing lesions, 3% diclofenac in a 2.5% hyal¬ uronic acid gel shows promise as another topical agent for the treatment of active keratosis, and our findings sug¬ gest that a double-blind randomized study is warranted.…”
Section: Provocative Use Testmentioning
confidence: 99%
“…In one study, esophageal squamous cancer cell lines were found to produce prostaglandins of both the E and F series, and the cells that produced the greater amounts of each were more metastatic in athymic mice. Cross et al 80 examined two tongue-derived squamous cell lines and found both to make PGE 2 and PGI 2 (prostacyclin). Both cell lines produced levels of PGE 2 that were high enough to cause immunosuppressive effects on leukocytes.…”
Section: Prostaglandin Metabolism In Cell Linesmentioning
confidence: 99%
“…Recently, Suen and Simonton-Atchley 93 reported on additional patients who experienced similar regres-sions with cyclooxygenase inhibition. Cross et al 80 demonstrated that treatment of patients for 2 weeks with indomethacin before head and neck cancer resection is associated with increased numbers of immune cell infiltrates in affected lymph nodes. Braun and Harris 55 have conducted several studies with NSAID and have been able to reverse many immune defects in patients with a variety of solid tumors.…”
Section: Clinical Studies With Prostaglandin Synthesis Inhibitorsmentioning
confidence: 99%
“…The antitumor effect of indomethacin on tumors in cancer patients 1,2) and in animals 3,4) has been described. We previously showed that indomethacin suppresses the growth of Colon 26 tumor in mice by enhancing the cellular immune function and improving cancer cachexia.…”
mentioning
confidence: 99%