Administration of a new diabetes-specific enteral formula results in an improved 24h glucose profile in type 2 diabetic patients

Ceriello, Antonio; Lansink, Mirian; Rouws, C.; Laere, K.M.J. van; Frost, Gary

doi:10.1016/j.diabres.2009.02.013

Cited by 28 publications

(31 citation statements)

References 44 publications

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“…and a form of maltodextrin that is resistant to amylase digestion in the small intestine [42]. Isomaltulose, found in the GTSN-I&RS beverage, is another low-glycemic index, slowly digestible carbohydrate [43][44][45][46][47] which has a hydrolyzation rate of 20% -25% that of sucrose [48]. The GTSN-TS&F product contained added fructose which has a very low-glycemic index and is often recommended, in limited quantities, in diabetes because it does not stimulate pancreatic beta-cell insulin secretion, and aids in glucose clearance through the liver [49].…”

Section: Discussionmentioning

confidence: 99%

Glycemic responses to glycemia-targeted specialized-nutrition beverages with varying carbohydrates compared to a standard nutritional beverage in adults with type 2 diabetes

Devitt¹,

Williams²,

Choe³

et al. 2013

ABB

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Background: Postprandial plasma glucose concentration is an important diabetes management target. Glycemia-targeted specialized-nutrition (GTSN) beverages, containing various quantities and types of carbohydrates (CHO), have been formulated to blunt postprandial hyperglycemia. The objective of this research was to evaluate the effectiveness of these products on postprandial glycemic and hormonal responses based on comparisons of GTSN with differing carbohydrate quantities or types. Methods: In two randomized, double-blind, crossover studies, participants (mean age 61 years) with type 2 diabetes consumed GTSN in a meal tolerance test. In the CHO Quantity Study, a standard nutritional beverage (STD) was compared to a low carbohydrate nutritional beverage with tapioca dextrin (GTSN-TDX) and a balanced carbohydrate nutritional beverage containing a blend of the slowly-digesting carbohydrates maltodextrin and sucromalt (GTSN-SDC). In the CHO Type Study, the GTSN beverages had similar carbohydrate quantities but varied in carbohydrate composition with GTSN-SDC compared to a formula with tapioca starch and fructose (GTSN-TS&F), and one with isomaltulose and resistant starch (GTSN-I&RS). Postprandial (0-240 min) concentrations of blood glucose, insulin (CHO Quantity Study only) and glucagon-like-peptide (GLP)-1 (CHO Quantity Study only) were measured. Results: Despite having substantially different carbohydrate quantities, the GTSN blunted the glucose positive area under the curve (AUC 0-240 min) by 65% to 82% compared to the STD formulation (p < 0.001). GTSN also elicited ~50% lower insulin positive AUC 0-240 min (p < 0.05), while postprandial GLP-1 responses were increased (p = 0.018) vs. STD. In the CHO Type Study, glucose positive AUC 0-240 min tended to be lower for GTSN-SDC (1477 ± 460) than GTSN-TS&F (2203 ± 412; p = 0.062) and GTSN-I&RS (2190 ± 412; p = 0.076). No differences were observed between GTSN-TS&F and GTSN-I&RS. Conclusions: These results demonstrate the effectiveness of several GTSN products and suggest that both CHO quantity and type play important roles in postprandial glycemic response in men and women with type 2 diabetes. Furthermore, GTSN products containing slow-digesting carbohydrates can blunt postmeal glucose and insulin concentration despite delivering greater total grams of CHO, which provides a dietary benefit for people with diabetes.

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Section: Discussionmentioning

confidence: 99%

Glycemic responses to glycemia-targeted specialized-nutrition beverages with varying carbohydrates compared to a standard nutritional beverage in adults with type 2 diabetes

Devitt¹,

Williams²,

Choe³

et al. 2013

ABB

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“…In this study, we found that insulin resistance and fasting glucose levels improved in ischemic stroke patients after 7 days on the DSF formula. Besides the DSF's low‐glucose index ingredients, such as slowly digestible carbohydrate, solute fiber and a high percentage of MUFA, we believe the types of proteins within the DSF was an important contributing factor to these effects . The DSF primarily contains soy protein, whereas the standard formula contains casein.…”

Section: Discussionmentioning

confidence: 99%

“…Besides the DSF's low-glucose index ingredients, such as slowly digestible carbohydrate, solute fiber and a high percentage of MUFA, we believe the types of proteins within the DSF was an important contributing factor to these effects. 20 The DSF primarily contains soy protein, whereas the standard formula contains casein. Compared with casein feed, soy protein has been shown to significantly improve insulin sensitivity and fasting glucose concentrations in patinets with metabolic syndrome and patients with diabetes.…”

Section: Discussionmentioning

confidence: 99%

Tube Feeding with a Diabetes‐Specific Enteral Formula Improves Glycemic Control in Severe Acute Ischemic Stroke Patients

Shao

Heng

et al. 2017

J Parenter Enteral Nutr

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“…Depending on the total energy and carbohydrate intake, as well as the individual response to the diet, saturated fat can therefore be replaced by either unsaturated fatty acid or carbohydrate. 1,2,7 Studies comparing diabetes-specific formulae with standard formulae have reported a neutral effect on glucose control and lipid management 14 ; a reduction in peak glucose values 15,16,17 ; a reduced HbA1c profile 15,16 ; lower postprandial glucose values 18 ; reduced insulin requirements 16 and no significant effect on lipid values. 14,16,18 Unfortunately, due to relatively small patient numbers and short duration of studies, as well as different feed compositions, it is difficult to compare results and to determine the clinical impact of the outcomes.…”

Section: Carbohydrate and Fat Contribution To Total Energymentioning

confidence: 99%

The use of specialised enteral formulae for patients with diabetes mellitus

Blaauw

2010

South African Journal of Clinical Nutrition

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Administration of a new diabetes-specific enteral formula results in an improved 24h glucose profile in type 2 diabetic patients

Cited by 28 publications

References 44 publications

Glycemic responses to glycemia-targeted specialized-nutrition beverages with varying carbohydrates compared to a standard nutritional beverage in adults with type 2 diabetes

Glycemic responses to glycemia-targeted specialized-nutrition beverages with varying carbohydrates compared to a standard nutritional beverage in adults with type 2 diabetes

Tube Feeding with a Diabetes‐Specific Enteral Formula Improves Glycemic Control in Severe Acute Ischemic Stroke Patients

The use of specialised enteral formulae for patients with diabetes mellitus

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