Administration and monitoring of intravenous anesthetics

Sahinovic, Marko; Absalom, Anthony; Struys, Michel

doi:10.1097/aco.0b013e3283404579

Cited by 24 publications

(14 citation statements)

References 62 publications

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“…1), when administered in combination. 1,2 Anaesthetists routinely combine drugs such as opioids and hypnotics in clinical practice. However, dosing is often based on building experience throughout years of training and local habits.…”

mentioning

confidence: 99%

Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration

Berg

Vereecke

Proost

et al. 2017

British Journal of Anaesthesia

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This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning interactions, with emphasis on graphic representation of interactions using isoboles and response surface models. It gives examples on how to transform this knowledge into clinically and educationally applicable (bedside) tools.

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mentioning

confidence: 99%

Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration

Berg

Vereecke

Proost

et al. 2017

British Journal of Anaesthesia

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“…TCI is a novel, individualized anesthesia method (Sahinovic et al, 2010). The results of this study showed that the MAP and HR values were stably maintained in both groups during the operation, although the values at the time of loss of consciousness were lower than those upon entering the operating room during the perioperative period.…”

Section: Discussionmentioning

confidence: 80%

Bispectral index for monitoring anesthetic depth in patients with severe burns receiving target-controlled infusion of remifentanil and propofol

et al. 2015

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ABSTRACT. This study evaluated the feasibility and effectiveness of using the bispectral index (BIS) to monitor anesthetic depth in patients with severe burns receiving intravenous target-controlled infusion (TCI) of remifentanil and propofol. We randomly assigned 80 patients undergoing elective escharectomy (<1 week) to BIS (A) and control (B) groups. All patients received remifentanil and propofol as intravenous TCI anesthesia. Clinical data were recorded at different time points. The time from drug withdrawal to eye opening upon the patient hearing his/ her name called and upon reaching an Aldrete score of 9 points was also recorded. During anesthesia maintenance, the target concentrations of remifentanil and propofol in group A were significantly lower than that in group B (2.12 ± 0.35 vs 2.50 ± 0.21 ng/mL and 2.54 ± 0.22 vs 2.86 ± 0.31 μg/mL, respectively; P < 0.01). The time from drug withdrawal to eye opening upon the patient hearing his/her name called and reaching an Aldrete score of 9 points in group A was considerably shorter than Z.G. Guo et al. 7598©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 7597-7604 (2015) that in group B (7.90 ± 0.58 vs 8.35 ± 0.66 min and 9.15 ± 0.69 vs 11.13 ± 0.96 min, respectively; P < 0.01). In both groups, mean arterial pressure and heart rate values at each time point after loss of consciousness were significantly lower than the baseline values (P < 0.05), with the exception of 2 min after intubation. The use of BIS to monitor anesthetic depth in patients with severe burns receiving TCI of remifentanil and propofol during the perioperative period reduces propofol consumption and shortens the consciousness recovery time in patients.

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“…The Paedfuser model was especially developed for children and tested in children aged 1-18 years and 5-61 kg body weight. It is recommended and accurate in patients aged 3-16 years and 15-61 kg body weight [46][47][48][49][50][51][52].…”

Section: Total Intravenous Anesthesia and Target-controlled Infusionmentioning

confidence: 98%

“…The first model developed was the Diprifusor [45,46]. After its patent expired, other models were developed like the Marsh model [46][47][48][49][50][51], the Schnider model [46][47][48][49][50][51], the Kataria model with the Katfuser [46,51], the Paedfuser model for children [52], and the White model [53,54 & ]. The above-mentioned open TCI systems can be programmed with any pharmacokinetic model and allow either plasma-site-targeting or effect-site-targeting.…”

Section: Total Intravenous Anesthesia and Target-controlled Infusionmentioning

confidence: 99%

Adult and pediatric anesthesia/sedation for gastrointestinal procedures outside of the operating room

Er¹

2015

Current Opinion in Anaesthesiology

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Both anesthesiologists and nonanesthesiologists have to achieve a consensus and develop quality-improvement strategies to provide safe and efficient anesthesia and sedation for gastrointestinal procedures outside of the operating room for pediatric and adult patients. Techniques using TIVA, TCI, intravenous or topical application of lidocaine, and the video laryngoscope may improve and facilitate gastrointestinal procedures for the patients, the anesthesiologists, and the gastroenterologists.

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Administration and monitoring of intravenous anesthetics

Abstract: Anesthetic drug administration might be optimized by applying knowledge from clinical pharmacokinetics and dynamics.

Cited by 24 publications

References 62 publications

Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration

Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration

Bispectral index for monitoring anesthetic depth in patients with severe burns receiving target-controlled infusion of remifentanil and propofol

Adult and pediatric anesthesia/sedation for gastrointestinal procedures outside of the operating room

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