Adlay hull extracts attenuate β-amyloid-induced neurotoxicity and oxidative stress in PC12 cells through antioxidative, anti-inflammatory, and antiapoptotic activities

Tsay, Gregory J.; Lin, Yu-Ta; Hsu, Chia-Hong; Tang, Feng‐Yao; Kuo, Yueh‐Hsiung; Chao, Che‐Yi

doi:10.1016/j.bbrep.2021.101020

Cited by 6 publications

(5 citation statements)

References 47 publications

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“…Those identified compounds with >70% of similarity based on mass spectral library are listed in Table 1. According to previous studies [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], 8 identified compounds in HWE and 9 compounds in HEE have been reported to exhibit antidiabetic, anti-inflammatory, or antioxidant properties based on in vitro and in vivo models. Among these compounds, vanillin, apocynin, methyl palmitate, and syringaldehyde have received considerable attention for their multiple pharmacological properties.…”

Section: Compound Identification In Hemp Root Extracts By Gas Chromat...mentioning

confidence: 99%

Protective Effects of Hemp (Cannabis sativa) Root Extracts against Insulin-Deficient Diabetes Mellitus In Mice

Kim

Kim³

et al. 2023

Molecules

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The pharmacological potential of industrial hemp (Cannabis sativa) has been widely studied. However, the majority of studies have focused on cannabidiol, isolated from the inflorescence and leaf of the plant. In the present study, we evaluated the anti-diabetic potential of hemp root water (HWE) and ethanol extracts (HEE) in streptozotocin (STZ)-induced insulin-deficient diabetic mice. The administration of HWE and HEE ameliorated hyperglycemia and improved glucose homeostasis and islet function in STZ-treated mice (p < 0.05). HWE and HEE suppressed β-cell apoptosis and cytokine-induced inflammatory signaling in the pancreas (p < 0.05). Moreover, HWE and HEE normalized insulin-signaling defects in skeletal muscles and apoptotic response in the liver and kidney induced by STZ (p < 0.05). Gas chromatography-mass spectrometry analysis of HWE and HEE showed possible active compounds which might be responsible for the observed anti-diabetic potential. These findings indicate the possible mechanisms by which hemp root extracts protect mice against insulin-deficient diabetes, and support the need for further studies geared towards the application of hemp root as a novel bioactive material.

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Section: Compound Identification In Hemp Root Extracts By Gas Chromat...mentioning

confidence: 99%

Protective Effects of Hemp (Cannabis sativa) Root Extracts against Insulin-Deficient Diabetes Mellitus In Mice

Kim

Kim³

et al. 2023

Molecules

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“…Alzheimer’s disease is characterized by the accumulation of β-amyloid in senile plaques, leading to the deterioration of brain function. Adlay hull water extracts may have a preventive therapeutic potential in the treatment of Alzheimer’s disease; particularly, its water extract Aβ25-35-induced apoptosis in dPC12 cells was associated with the enhancement of the PI3K/Akt signaling pathway [ 82 ].…”

Section: Action Pathway Against Disease Of Adlaymentioning

confidence: 99%

“…Adlay bran free phenolics are the most potent cellular anti-oxidants; they suppressed the generation of MDA, MetHb, and ROS and activated ATPase, CAT, SOD, and GSH-Px [ 128 ]. An extract (phenolics, flavonoids, coniferyl alcohol, and 4-ketopinoresinol) of adlay hull has anti-inflammatory and protective effects via Aβ-induced neurotoxicity and apoptosis in dPC12 cells, and can also treat neurodegenerative disorders (Alzheimer’s disease) [ 82 ]. The 20 phenolics (10 phenolic acids, 2 coumarins, 2 phenolic aldedhyes, and 6 flavonoids) from adlay bran, especially sinapic acid and phenolic acids, show strong xanthine oxidase inhibitory activity, and are effective drugs in the prevention and treatment of hyperuricemia [ 134 ].…”

Section: Functional Ingredients Mechanisms In Adlay To Combat Diseasementioning

confidence: 99%

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Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health

Zeng

Yang²,

Chen

et al. 2022

Molecules

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Medicinal and food homologous adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) plays an important role in natural products promoting human health. We demonstrated the systematic actional mechanism of functional ingredients in adlay to promote human health, based on the PubMed, CNKI, Google, and ISI Web of Science databases from 1988 to 2022. Adlay and its extracts are rich in 30 ingredients with more than 20 health effects based on human and animal or cell cultures: they are anti-cancer, anti-inflammation, anti-obesity, liver protective, anti-virus, gastroprotective, cardiovascular protective, anti-hypertension, heart disease preventive, melanogenesis inhibiting, anti-allergy, endocrine regulating, anti-diabetes, anti-cachexia, osteoporosis preventive, analgesic, neuroprotecting, suitable for the treatment of gout arthritis, life extending, anti-fungi, and detoxifying effects. Function components with anti-oxidants are rich in adlay. These results support the notion that adlay seeds may be one of the best functional foods and further reveal the action mechanism of six major functional ingredients (oils, polysaccharides, phenols, phytosterols, coixol, and resistant starch) for combating diseases. This review paper not only reveals the action mechanisms of adding adlay to the diet to overcome 17 human diseases, but also provides a scientific basis for the development of functional foods and drugs for the treatment of human diseases.

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“…Besides being used as food, animal feed, and handicrafts, people in Asian countries also use hanjeli for traditional medicine. 6,7 *Corresponding author. E mail: sumarlin@uinjkt.ac.id Tel: +62- This plant have been traditionally applied for treating diuretic, antirheumatic, antispasmodic, anti-inflammatory, antidiarrheal, anthelmintic, antipyretic, antispasmodic, diuretic, hypoglycaemic, antioxidant, antifungal, and anti-cancer.…”

Section: Introductionmentioning

confidence: 99%

Screening of Antibacterial Compounds Against Escherichia coli from Hanjeli Seeds (Coix lacryma-jobi) Based on Metabolomics

2023

TJNPR

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Hanjeli seed (Coix lacryma-jobi L.) is one of the important plants used as raw materials for food and traditional medicine. In addition, hanjeli seed also has several biological activities, one of which is antibacterial activity comes from the activity of the metabolites contained in the extract of the seed. This study aims to determine the antibacterial activity of hanjeli seed extract and identify the metabolites contained in some selected extracts using a metabolomics approach. Hanjeli seed was extracted with distilled water, 50% ethanol, 96% ethanol, and n-hexane. The crude extracts of hanjeli seed were evaluated for the activity against Escherichia coli ATCC 25922 and the metabolites were identified using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). Hanjeli seed extracts had antibacterial activity ranging from 7.85±4.48 to 27.99±6.02%, with 50% ethanol extract had the highest antibacterial activity and nhexane extract had the lowest. LC-MS/MS analysis of the 50% ethanol extract obtained 22 metabolites which were putatively identified. The antibacterial activity of the hanjeli seed extract is predicted to be caused by the phenolic compounds, such as gluconic acid, quinic acid, malic acid, citric acid, p-coumaric acid, and ferulic acid. The phenolic compounds contained in the hanjeli seed extract can inhibit the growth of E. coli, so that the extract can be applied as an antibacterial against E. coli.

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Adlay hull extracts attenuate β-amyloid-induced neurotoxicity and oxidative stress in PC12 cells through antioxidative, anti-inflammatory, and antiapoptotic activities

Cited by 6 publications

References 47 publications

Protective Effects of Hemp (Cannabis sativa) Root Extracts against Insulin-Deficient Diabetes Mellitus In Mice

Protective Effects of Hemp (Cannabis sativa) Root Extracts against Insulin-Deficient Diabetes Mellitus In Mice

Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health

Screening of Antibacterial Compounds Against Escherichia coli from Hanjeli Seeds (Coix lacryma-jobi) Based on Metabolomics

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