Adjuvant treatment with Yupingfeng formula for primary nephrotic syndrome in children

Shi, Xinmiao; Zhong, Xuhui; Ding, Jie

doi:10.1097/md.0000000000011598

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…Milkvetch root can increase plasma albumin, reduce urinary protein excretion, decrease serum cholesterol and triglycerides, and improve clinical remission rate in children with PNS with a positive effect on the treatment of adrenal syndrome [11]. In addition, milkvetch root-type formulations of Huaiqihuang, Yupingfeng, and Shenkangling also have good efficacy in improving remission rates and reducing relapse rates [12][13][14]. However, milkvetch root and milkvetch root-type formulas are mainly applied to children with TCM evidence of Qi deficiency of the lung and spleen, and the effects of other TCM prescriptions in children with PNS have not been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy of Adjuvant Treatment of Primary Nephrotic Syndrome in Pediatric Patients with Chinese Medicine

Zhang

Liu

et al. 2022

Journal of Healthcare Engineering

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Objective. Current study aimed to investigate the benefits of adjuvant therapy with traditional Chinese medicine on the pediatric primary nephrotic syndrome. Methods. A total of 455 patients with PNS admitted to our hospital from January 2010 to January 2019 were divided into the traditional Chinese medicine group (n = 217) and the control group (n = 238). The control group received conventional Western medical treatment, and the traditional Chinese medicine group was treated with traditional Chinese medicine supplemented with Western medical treatment. The differences in remission rate, recurrence rate, and recurrence-free survival between the two groups were evaluated. Results. The differences in clinical parameters between the two groups were not statistically significant. Compared with the control group, adjuvant treatment with traditional Chinese medicine increased the clinical remission rate ( p = 0.037 ), decreased the relapse rate ( p = 0.015 ), prolonged relapse-free survival ( p ≤ 0.01 ), and was an independent protective factor for relapse-free survival in children with PNS (HR = 0.55, 95% CI 0.49–0.63, p ≤ 0.01 ). In a subgroup analysis of the traditional Chinese medicine formulations, Yuebi Jiazhu Tang, Ganlu Xiaodu Dan, and Yupingfeng granules significantly reduced the risk of recurrence in children ( p ≤ 0.01 , p ≤ 0.01 , p = 0.003 ). Conclusion. Adjuvant treatment of pediatric primary nephrotic syndrome with traditional Chinese medicine could benefit the children.

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Section: Discussionmentioning

confidence: 99%