Adjuvant Therapy with Essential Fatty Acids (EFAs) for primary liver tumors: Some hypotheses

Baronzio, Gian Franco; Solbiati, Luigi; Ierace, Tiziana; Barzaghi, F.; Suter, Fredy; Airoldi, Mario; Belloni, G; Ravagnani, Fernando; Notti, P.; Gramaglia, Alberto; Galante, F.; Livraghi, Tito

doi:10.1016/0306-9877(95)90126-4

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…Hahn et al have shown that metabolic state and energy deprivation increase the heat sensitivity [81]. This aspect, suggests the use of HT with Trans Arterial Chemoembolization (TACE) Another important aspect is related to the change in the composition of the membranes as shown by the groups of Tanaka H and Kokura suggested by one of our group already in 1995 [82][83][84]. Before discussing the positive association between radiotherapy chemotherapy and hyperthermia is useful to discuss the effects of hyperthermia on tumor apoptosis.…”

Section: • Mitochondria Suffer Different Alterations In Their Cristaementioning

confidence: 99%

A Brief Overview of Hyperthermia in Cancer Treatment

Baronzio¹,

Parmar²,

Ballerini³

et al. 2014

J Integr Oncol

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Despite the large economic and intellectual efforts, cancer is still not easily treatable disease by conventional therapies. This led ultimately to reconsider hyperthermia, like one of interesting treatment methods connected to immunity and tumor metabolism. Hyperthermia has also the ability to play an additional role when used together with the conventional methods of treatment: surgery, radiotherapy, chemotherapy and immunotherapy. Recent trials in Holland and Germany have demonstrated that hyperthermia can prolong life and decrease disease re-appraisal when used in combination with radiotherapy and chemotherapy. Some tumors seem more responsive than others. In this brief summary we will attempt to give a vision of hyperthermia from a physical stand point, but more importantly we will give clinical and biological aspects. The results obtained in these trials on certain types of cancers such as cervix cancer, recurrent breast cancer and head neck cancer, melanoma, sarcomas, liver, glioblastoma and pancreatic cancer support the use of this technique, although some clinical and technical problems persist and have not been completely resolved.

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Section: • Mitochondria Suffer Different Alterations In Their Cristaementioning

confidence: 99%

A Brief Overview of Hyperthermia in Cancer Treatment

Baronzio¹,

Parmar²,

Ballerini³

et al. 2014

J Integr Oncol

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“…This inhibitory effect may be related to the accumulation of lipid peroxidation products in the tumor tissues (8) or to a decrease of oncogene expression (11), production of PGE 2 , tumor necrosis factor, and interleukin-1 (11,12).…”

mentioning

confidence: 98%

Dose‐dependent inhibition of cell proliferation induced by lipid peroxidation products in rat hepatoma cells after enrichment with arachidonic acid

Muzio

Salvo

Trombetta

et al. 1999

Lipids

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Polyunsaturated fatty acids (PUFA) are important constituents of membrane phospholipids, whose levels are decreased in some tumor cells. This deficiency may cause alterations in signal transduction and an interruption of normal cellular events. The enrichment of tumor cells with PUFA may stimulate or inhibit tumor growth, probably depending on the type of PUFA and the cellular concentration of aldehydes derived from restored lipid peroxidation. We examined the effect of several doses of prooxidant on the growth of hepatoma cells with different aldehyde dehydrogenase activities, enriched with arachidonic acid. Two doses of prooxidant were sufficient to reduce growth of hepatoma cells with low aldehyde dehydrogenase activity, whereas three doses were necessary for those with high enzyme activity. In both cases, lipid peroxidation products blocked the cells in the S phase.

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“…Several studies have shown that the FA composition of cancer cells can be altered in vitro and in vivo by supplementation with dietary FA (21)(22)(23). The resultant changes in the FA content of the tumor may alter prostaglandin synthesis and relevant signaling pathways, thereby modulating the apoptotic/proliferative imbalance (24). The present study was conducted to monitor the effect of low n-6/n-3 FA ratio diets on the PUFA and oxidative status, and the modulating role on hepatocyte nodule development.…”

mentioning

confidence: 99%

Dietary modulation of fatty acid profiles and oxidative status of rat hepatocyte nodules: Effect of different n−6/n−3 fatty acid ratios

Abel

Kock

Smuts

et al. 2004

Lipids

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Male Fischer rats were fed the AIN 76A diet containing varying n-6/n-3 FA ratios using sunflower oil (SFO), soybean oil (SOY), and SFO supplemented with EPA-50 and GLA-80 (GLA) as fat sources. Hepatocyte nodules, induced using diethylnitrosamine followed by 2-acetylaminofluorene/partial hepatectomy promotion, were harvested, with surrounding and respective dietary control tissues, 3 mon after partial hepatectomy. The altered growth pattern of hepatocyte nodules in rats fed SFO is associated with a distinct lipid pattern entailing an increased concentration of PE, resulting in increased levels of 20:4n-6. In addition, there is an accumulation of 18:1 n-9 and 18:2n-6 and a decrease in the end products of the n-3 metabolic pathway in PC, suggesting a dysfunctional delta-6-desaturase enzyme. The hepatocyte nodules of the SFO-fed rats exhibited a significantly reduced lipid peroxidation level that was associated with an increase in the glutathione (GSH) concentration. The low n-6/n-3 FA ratio diets significantly decreased 20:4n-6 in PC and PE phospholipid fractions with a concomitant increase in 20:5n-3, 22:5n-3, and 22:6n-3. The resultant changes in the 20:4/20:5 FA ratio and the 20:3n-6 FA level in the case of the GLA diet suggest a reduction of prostaglandin synthesis of the 2-series. The GLA diet also counteracted the increased level of 20:4n-6 in PE by equalizing the nodule/surrounding ratio. The low n-6/n-3 ratio diets significantly increased lipid peroxidation levels in hepatocyte nodules, mimicking the level in the surrounding and control tissue while GSH was decreased. An increase in n-3 FA levels and oxidative status resulted in a reduction in the number of glutathione-S-transferase positive foci in the liver of the GLA-fed rats. Modulation of cancer development with low n-6/n-3 ratio diets containing specific dietary FA could be a promising tool in cancer intervention in the liver.

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Adjuvant Therapy with Essential Fatty Acids (EFAs) for primary liver tumors: Some hypotheses

Cited by 8 publications

References 37 publications

A Brief Overview of Hyperthermia in Cancer Treatment

A Brief Overview of Hyperthermia in Cancer Treatment

Dose‐dependent inhibition of cell proliferation induced by lipid peroxidation products in rat hepatoma cells after enrichment with arachidonic acid

Dietary modulation of fatty acid profiles and oxidative status of rat hepatocyte nodules: Effect of different n−6/n−3 fatty acid ratios

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