Adjuvant Therapy of T1 Bladder Carcinoma: Preliminary Results of an EORTC Randomized Study

Effects of Local Chemotherapy and Immunotherapy on the Recurrence and Progression of Superficial Bladder Cancer

“…Some authors have shown that despite the application of thio-TEPA, 10 % of superficial tumours become invasive, the same as when prophylactic chemotherapy is not applied [10]. As stated earlier, the prophylactic effect of BCG vaccine on recurrence is not debated, while the effect on progression has not been determined [8,12,13].…”

“…In other words, in terms of recurrence and progression, the poorest results were found for the group treated by TUR only, and the best results were found with the TUR and BCG group. progression of the illness [8][9][10], Also the local immuno therapy was undertaken with intravesical instillation of BCG vaccine. Opinions regarding its positive effects on the frequency of recurrence are generally uniform [11 -13].…”

Intravesical Single and Combination Therapy in Superficial Bladder Cancer

“…Up to now, the instillations were performed as a single drug therapy only. Randomized prospective studies could not prove the positive effect of the treatment con cerning the overall incidence of recurrences [Byar and Blackard, 1977;Jacobi et al, 1978;Nieh et al, 1978;Schulman et al, 1979], In this animal experiment it was investigated if com bination therapy gives better results than topical instilla tion of one drug only.…”