Adjuvant therapies using normobaric oxygen with hypothermia or ethanol for reducing hyperglycolysis in thromboembolic cerebral ischemia

Cai, Lining; Stevenson, J. A. F.; Peng, Changya; Xin, Ruiqiang; Rastogi, Radhika; Liu, K.; Xu, Geng; Gao, Zhi; Ji, Xunming; Rafols, José A.; Ji, Zhili; Ding, Yuchuan

doi:10.1016/j.neuroscience.2016.01.010

Cited by 18 publications

(13 citation statements)

References 64 publications

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“… Cai et al (2016) and Cai, Thibodeau, et al (2016) reported that the administration of ethanol as a single (1 g/kg intra-femoral injection) or a combinatory compound with normobaric oxygen and hypothermia reduced the neurological deficits. Wang et al reported that ethanol at a dose of 1.5 g/kg exerted a neuroprotective effect when administrated 4 h after the onset of ischemia ( Zhang et al, 2012 ), and also improved the neurological function up to 48% ( Ryan et al, 2013 ) and motor function about 2–28 days after the induction of stroke in rats ( Zhang et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

“…Neuroprotective compounds have been widely developed due to their significant therapeutic effectiveness (Beraki et al, 2013). Ethanol as a neuroprotective agent possesses useful properties, such as availability, being well-tolerated, and easy mode of administration, as well as merely diffusion across the Blood-Brain Barrier (BBB) (Cai, Stevenson, et al, 2016). That light-to-moderate consumption of alcoholic beverages has shown with neuroprotective effects after the ischemia (Cai, Stevenson, et al, 2016;Cai, Thibodeau, et al, 2016;Kochanski et al, 2013;McCarter et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…It (1.5 g/kg) improved the motor behavior 2 to 28 days after the stroke ( Zhang et al, 2012 ) and reduced the neurological deficits by 48% at 24 h post-reperfusion ( Ryan et al, 2013 ). Combination therapy of ethanol (1.0 g/kg), hypothermia, and Normobaric hyperoxia can result in a more significant reduction in neurological deficits evaluated 24 h after tPA administration ( Cai, Stevenson, et al, 2016 ; Cai, Thibodeau, et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

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Behavioral Changes in Combination Therapy of Ethanol and Modafinil on rats Focal Cerebral Ischemia

Abbasi

Mousavizadeh

Shabani

et al. 2020

Basic Clin. Neurosci. J.

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Ethanol is considered as an effective agent in reducing brain stroke injury. In this study, we assessed the effects of modafinil along with ethanol as a combination therapy on behavioral function in Wistar rats. Methods: The right Middle Cerebral Artery Occlusion (MCAO) was performed and the rats were divided into nine groups (n=8 per group). The animal groups in this study were as follows: 1. MCAO control group (ischemia without treatment); 2. Vehicle group; 3. Modafinil group that was randomly subdivided into three groups receiving different doses of modafinil (10, 30, and 100 mg/kg) for 7 days before MCAO; 4. Ethanol group receiving 1.5 g/kg ethanol at the time of reperfusion; 5. Modafinil + ethanol group that was further subdivided into three groups receiving modafinil at different doses (10, 30, and 100 mg/kg) for 7 days before MCAO and ethanol at the time of reperfusion. The motor behavior was measured using the Garcia test 24, 48, and 72 h after the ischemia, and the elevated body swing test was performed 48 and 72 h after the ischemia. The anxiety and locomotor activity were analyzed by open field test 48 and 72 h post-ischemia. Results: The results showed that the neurological deficit score, locomotor activity, and unexpected thigmotaxis (anxiety) in the ethanol, modafinil (in a dose-dependent manner), and ethanol+modafinil treatment groups were significantly higher than the MCAO control group. Conclusion: It seems that the combination therapy of modafinil (100 mg/kg) and ethanol (1.5 g/kg) significantly enhanced neuroprotection via an improvement in locomotor activity and neurological functions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Behavioral Changes in Combination Therapy of Ethanol and Modafinil on rats Focal Cerebral Ischemia

Abbasi

Mousavizadeh

Shabani

et al. 2020

Basic Clin. Neurosci. J.

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“…In recent years, it has been found that hypothermia combined with oxygen therapy has a better effect on cerebrovascular diseases. Cai et al42 also found that NBO and hypothermia treatment can produce better brain protection. Sprague-Dawley rats were subjected to middle cerebral artery occlusion with an autologous embolus.…”

Section: Experimental Studiesmentioning

confidence: 96%

Combined application of hypothermia and medical gases in cerebrovascular diseases

Tan

Xue

et al. 2018

Med Gas Res

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Cerebrovascular diseases have a heavy burden on society and the family. At present, in the treatment of cerebrovascular diseases, the recognized effective treatment method is a thrombolytic therapy after cerebral infarction, but limited to the time window problem, many patients cannot benefit. Other treatments for cerebrovascular disease are still in the exploration stage. The study found that medical gas and hypothermia have brain protection effects. Further research found that when the two are used in combination, the therapeutic effect has a superimposed effect. This article reviews the current research progress of hypothermia therapy combined with medical gas therapy for cerebrovascular disease.

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“…These effects were associated with an increase in pyruvate dehydrogenase activity and protein expression. Combining NBO with hypothermia reduced reperfusion injury by modulating NADPH oxidase activity and attenuating hyperglycolysis [ 99 , 100 ].…”

Section: Combination Therapy Involving Normo- and Hyperbaric Oxygementioning

confidence: 99%

Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence

Zhang

Ding

et al. 2018

Aging and disease

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Ischemic stroke is a major cause of death and disability globally, and its incidence is increasing. The only treatment approved by the US Food and Drug Administration for acute ischemic stroke is thrombolytic treatment with recombinant tissue plasminogen activator. As an alternative, therapeutic hypothermia has shown excellent potential in preclinical and small clinical studies, but it has largely failed in large clinical studies. This has led clinicians to explore the combination of therapeutic hypothermia with other neuroprotective strategies. This review examines preclinical and clinical progress towards developing highly effective combination therapy involving hypothermia for stroke patients.

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Adjuvant therapies using normobaric oxygen with hypothermia or ethanol for reducing hyperglycolysis in thromboembolic cerebral ischemia

Cited by 18 publications

References 64 publications

Behavioral Changes in Combination Therapy of Ethanol and Modafinil on rats Focal Cerebral Ischemia

Behavioral Changes in Combination Therapy of Ethanol and Modafinil on rats Focal Cerebral Ischemia

Combined application of hypothermia and medical gases in cerebrovascular diseases

Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence

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