Adjuvant regimens with trastuzumab administered for small HER2-positive breast cancer in routine clinical practice

Breast cancer (BC) is the most common cancer in women worldwide, and has an undeniable negative impact on public health. The advent of molecular biology and immunotherapy has made targeted therapeutic interventions possible, providing treatments tailored to the individual characteristics of the patient and the disease. The over-expression of human epidermal growth factor receptor (HER) 2 is implicated in the pathophysiology of BC and represents a clinically relevant biomarker for its treatment. Trastuzumab, a recombinant antibody targeting HER2, was the first biological drug approved for the treatment of HER2-positive BC. Although there are currently other anti-HER2 agents available (e.g. pertuzumab and lapatinib), trastuzumab remains the gold standard for treatment of this disease subtype. Nonetheless, concerns have been raised regarding potential cardiotoxicity and treatment resistance. Moreover, several other therapeutic issues remain unclear and have been addressed in an inconsistent way. The current literature lacks a comprehensive review of trastuzumab providing useful information for clinical practice, including pharmacokinetic and pharmacodynamic aspects, its clinical use, existing controversies and future advances. This detailed review of trastuzumab in the pharmacotherapy of BC attempts to fill this gap.

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Trastuzumab in the Treatment of Breast Cancer

Maximiano

et al. 2016

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Trastuzumab

2015

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Protein Tyrosine Phosphatase Interacting Protein 51 Research Progress

于¹

2021

ACM

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Adjuvant regimens with trastuzumab administered for small HER2-positive breast cancer in routine clinical practice

Abstract: This study shows that trastuzumab-based adjuvant treatment of small HER2-positive breast cancer is mostly based on chemotherapy-mainly paclitaxel/docetaxel. Adjuvant administration of trastuzumab for small HER2-positive breast cancer seems to be similar to that used for larger tumors.

Cited by 3 publications

References 30 publications

Trastuzumab in the Treatment of Breast Cancer

Trastuzumab in the Treatment of Breast Cancer

Trastuzumab

Protein Tyrosine Phosphatase Interacting Protein 51 Research Progress

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