Adjuvant Radiotherapy After Minimally Invasive Surgery in Patients With Stage IA1-IIA1 Cervical Cancer

Gan, Yi-Xiu; Du, Qian; Li, Jian; Wei, Ye-ping; Jiang, Xu-wei; Xu, Xuemei; Yue, Haiying; Li, Xiangde; Zhu, Huijun; Ou, Xue; Zhong, Qiuan; Luo, Di; Liang, Qian-Fu; Xie, Yiting; Zhang, Qiangqiang; Li, Ge-li; Shang, Yuan-ting; Liu, Wenqi

doi:10.3389/fonc.2021.690777

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…The results may differ due to several factors. Firstly, the surgical-related factors that result in poor patient survival, such as utilizing a uterine manipulator, the effect of insufflation gas (CO 2 ), and the degree of resection, can be improved by postoperative RT or CRT [18][19][20]. Secondly, many studies indicated that a longer adjuvant RT wait-time after RH result in poorer oncologic outcome in early-stage CC [21,22].…”

Section: Discussionmentioning

confidence: 99%

The impacts of minimally invasive surgery on intermediate- or high-risk cervical cancer patients received adjuvant radiotherapy

Zhang

Wang

et al. 2022

World J Surg Onc

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Background Adjuvant chemoradiotherapy (CRT) has been shown to reduce the risk of recurrence for patients with risk factors after radical hysterectomy (RH). Early initiated CRT could result in superior oncological outcomes. Here, we aimed to compare the survival outcome of intermediate- or high-risk cervical cancer (CC) patients who, received adjuvant CRT between minimally invasive surgery (MIS) and open surgery. Methods Data on stage IB1-IIA2 patients who underwent RH and postoperative CRT in our institution, from 2014 to 2017, were retrospectively collected. Patients with high or intermediate-risk factors who met the Sedlis criteria received sequential chemoradiation (SCRT). According to the surgical approaches, the enrolled patients were divided into MIS and open surgery groups. Then, the disease-free survival (DFS), overall survival (OS), and prognostic factors were analyzed. Results Among 129 enrolled CC patients, 68 received open surgery and 61 received MIS. The median time interval from surgery to chemotherapy and to radiotherapy was shorter in the MIS group (7 days vs. 8 days, P=0.014; 28 days vs. 35, P<0.001). Three-year DFS and OS were similar in both groups (85.2% vs. 89.7%, P=0.274; 89.9% vs. 98.5%, P=0.499). Further, sub-analysis indicated that the DFS and OS in intermediate/high-risk groups had no significant difference. Cox-multivariate analyses found that tumor size >4 cm and time interval from surgery to radiotherapy beyond 7 weeks were adverse independent prognostic factors for DFS. Conclusion Based on the population we studied, for early-stage (IB1-IIA2) CC patients with intermediate- or high-risk factors who received postoperative SCRT, although the difference was not significant, the DFS and OS in the MIS group were slightly lower than the ORH group, and tumor size >4 cm and delayed adjuvant radiotherapy beyond 7 weeks were risk factors for recurrence.

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Section: Discussionmentioning

confidence: 99%

The impacts of minimally invasive surgery on intermediate- or high-risk cervical cancer patients received adjuvant radiotherapy

Zhang

Wang

et al. 2022

World J Surg Onc

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“…They observed a statistically significant increase in 3-year local recurrence-free survival (LRFS) in patients who received adjuvant RT compared to surgery alone. [18] Solis et al analyzed the data of 28 patients who underwent adjuvant small pelvic field radiotherapy without brachytherapy or chemotherapy for intermediate risk. They reported OS, DFS and LRFS as 100%, 82% and 86% respectively at a median follow-up of 41 months.…”

Section: Rotman Et Al Investigated the Role Of Postoperative Rt In Amentioning

confidence: 99%

Erken Evre Serviks Kanserinde Sedlis Kriterleri Gözönünde Bulundurularak Uygulanan Adjuvant Radyoterapi Sonuçları

GÜRDAL¹,

Gürsel²

2023

Journal of Contemporary Medicine

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Background/Aims: Investigation of the efficacy of adjuvant RT in cervical cancer stage I-IIA according to FIGO (2018) in terms of risk factors and oncologic outcomes. Methods: The study included 113 patients with FIGO stage I-IIA. Patients who received adjuvant external pelvic RT and/or intracavitary brachytherapy (ICBT) after surgery retrospectively analyzed for demographic data , histology, grade, tumor size , stage, LVSI, stromal invasion depth, type of lymphadenectomy, number of dissected pelvic / paraaortic lymph nodes , surgical margin, adjuvant therapies, local relapse, distant failure, overall survival, and progression-free survival. Results: After a median follow-up of 160 months, local recurrence was observed in 3 patients, distant metastasis in 6 patients and all-cause death in 15 patients. It was observed that only SID had a statistically significant effect on overall survival among the Sedlis criteria (p=0.04). The ten-year DFS and OS rates were 95% and 94%, respectively . Conclusions: Promising oncological results were obtained in early stage cervical cancer with adjuvant RT based on Sedlis criteria.

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Adjuvant Radiotherapy After Minimally Invasive Surgery in Patients With Stage IA1-IIA1 Cervical Cancer

Cited by 2 publications

References 28 publications

The impacts of minimally invasive surgery on intermediate- or high-risk cervical cancer patients received adjuvant radiotherapy

The impacts of minimally invasive surgery on intermediate- or high-risk cervical cancer patients received adjuvant radiotherapy

Erken Evre Serviks Kanserinde Sedlis Kriterleri Gözönünde Bulundurularak Uygulanan Adjuvant Radyoterapi Sonuçları

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