Adjuvant Potential of CD24 on Immunogenicity and Lethal Challenge Protection
of a DNA vector Expressing Nucleocapsid Protein of
Crimean Congo Hemorrhagic Fever Virus
Abstract:Crimean Congo hemorrhagic fever virus (CCHFV) is the causative agent of a globally-spread tick-borne zoonotic infection with an eminent risk of fatal human disease. Imminent public health threat posed by disseminated virus activity and lack of an approved therapeutic make CCHFV an urgent target for vaccine development. We described the construction of a DNA vector expressing nucleocapsid protein (N) of CCHFV (pV-N13) and investigated its potential to stimulate cytokine and total/specific antibody responses in … Show more
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