Adjuvant immunotherapy by levamisole in resectable lung cancer: A control study

Bestatin in Resected Lung Cancer A randomized clinical trial

“…Amery (24) reported, from a randomized trial with levamisole, no overall effect in stages I and I1 lung cancer, but found that a group given more than 80 mg/m2 levamizole did significantly better than the controls. Van Houtte et al (25) found no effect of levamisole in a randomized trial on resectable lung cancer. Yasumoto et al (26) reported a significant improvement of survival rate in resectable lung cancer by Nocardia rubra cell-wall skeleton (N-CWS).…”

Review: Perioperative therapy for locoregional nonsmall-cell lung cancer

“…Another trial of randomized adjuvant immunotherapy with levamisole by Van Houtte and associates [48] in 51 patients with Stage I and I1 lung carcinoma showed no effectiveness of the treatment. The dosage of levamisole, however, was different from that of Amery: 100 mg/m?…”

Immunotherapy of Lung Cancer

“…After a minimum of over one year of followup, Houtte and associates found no difference between the effects of levamisole as an adjuvant treatment to surgery for non-small cell lung carcinoma and the effects of surgery alone. 59 Pines performed a randomized study of combined adjuvant immunotherapy (levamisole plus BCG) following radical radiotherapy for squamous cell carcinoma of the bronchus. 103 After one year, the tumor metastases and the mortality rate were lower if BCG was given biweekly but not if it was given monthly.…”