Adjuvant effects of prostaglandin D2 to cisplatin on human ovarian cancer cell growth in nude mice

La prostaglandine D2

“…Le traitement par la PGD2 de deux lignées ovariennes tumorales d'origine épithéliale (BG1) ou provenant de la granulosa (Cov434) induit une diminution de leur croissance et une augmentation de leur apoptose, via le récepteur DP1 et l'activation de l'expression de SOX9 ( Figure 3B) [45]. Une telle inhibition des cellules ovariennes KF (dérivées d'un adénocarcinome séreux humain) a été rapportée antérieurement in vitro [46] et in vivo dans des expériences de xénogreffes [47]. Par ailleurs, l'activation de l'expression de la L-PGDS par l'acide rétinoïque est responsable de l'inhibition de croissance des cellules ovariennes tumorales 3AO en culture [48].…”

The mitochondrial gene-CMPK2 functions as a rheostat for macrophage homeostasis

“…The enormous metabolic flexibility offered by mitochondria resident processes forms the basis of cellular plasticity facilitating fine-tuned responses to physiological conditions ( 27 , 28 ). The importance of mitochondrial health in terms of physiology, network architecture in immune cell function, and response to infection is well recognized ( 29 – 31 ). Activated M1 polarized macrophages demonstrate an important shift in the metabolic state relying completely on glycolysis for increased and faster production of energy ( 29 , 32 – 35 ).…”

“…The importance of mitochondrial health in terms of physiology, network architecture in immune cell function, and response to infection is well recognized ( 29 – 31 ). Activated M1 polarized macrophages demonstrate an important shift in the metabolic state relying completely on glycolysis for increased and faster production of energy ( 29 , 32 – 35 ). This transition is associated with a distinctive change in mitochondrial structure and a diminished reliance on mitochondrial oxidative phosphorylation and increased production of mitochondrial reactive oxygen species (ROS) ( 36 – 39 ).…”

The mitochondrial gene CMPK2 functions as a rheostat for macrophage homeostasis in inflammation

“…The enormous metabolic flexibility offered by mitochondria resident processes forms the basis of cellular plasticity facilitating fine-tuned responses to physiological conditions (Labbe et al, 2014; Picard and McEwen, 2018). The importance of mitochondrial health in terms of physiology, network architecture in immune cell function and response to infection is well recognized (Kikuchi et al, 1988; Rambold and Pearce, 2018; Weinberg et al, 2015). Activated M1 polarized macrophages demonstrate an important shift in the metabolic state relying completely on glycolysis for increased and faster production of energy(Blagih and Jones, 2012; Kikuchi et al ., 1988; Newsholme et al, 1986; Rodriguez-Prados et al, 2010; Viola et al, 2019).…”

“…The importance of mitochondrial health in terms of physiology, network architecture in immune cell function and response to infection is well recognized (Kikuchi et al, 1988; Rambold and Pearce, 2018; Weinberg et al, 2015). Activated M1 polarized macrophages demonstrate an important shift in the metabolic state relying completely on glycolysis for increased and faster production of energy(Blagih and Jones, 2012; Kikuchi et al ., 1988; Newsholme et al, 1986; Rodriguez-Prados et al, 2010; Viola et al, 2019). This transition is associated with a distinctive change in mitochondrial structure and a diminished reliance on mitochondrial oxidative phosphorylation and increased production of mitochondrial ROS(Kelly and O’Neill, 2015; Labadarios et al, 1987; Mills et al, 2016; Van den Bossche et al, 2016).…”