Adjuvant effect of DEAE-dextran on cholera vaccines

Joó, I.; Emöd, J.

doi:10.1016/0264-410x(88)90217-4

Cited by 21 publications

(7 citation statements)

References 15 publications

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“…DEAE-Dextran mixed with formalin-inactivated Venezuelan equine encephalomyelitis virus exhibited a significant adjuvant effect on the primary immune response in rhesus monkeys [ 169 ]. In a whole-cell vaccine, DEAE- combined with Vibrio cholerae produced a higher and longer-lasting antibody titer than the one elicited by vaccines without adjuvant; furthermore, there was a greater protection against cholera re-infection [ 170 ]. In a breast cancer model, DEAE- induced the production of IFN-beta inhibiting the gene expression of the vascular endothelial growth factor (VEGF) gene and the NOTCH1 gene both related to angiogenesis and tumorigenesis [ 172 ].…”

Section: Assemblies Based On Cationic Polymersmentioning

confidence: 99%

Cationic Nanostructures for Vaccines Design

Carmona-Ribeiro

Betancourt

2020

Biomimetics

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Subunit vaccines rely on adjuvants carrying one or a few molecular antigens from the pathogen in order to guarantee an improved immune response. However, to be effective, the vaccine formulation usually consists of several components: an antigen carrier, the antigen, a stimulator of cellular immunity such as a Toll-like Receptors (TLRs) ligand, and a stimulator of humoral response such as an inflammasome activator. Most antigens are negatively charged and combine well with oppositely charged adjuvants. This explains the paramount importance of studying a variety of cationic supramolecular assemblies aiming at the optimal activity in vivo associated with adjuvant simplicity, positive charge, nanometric size, and colloidal stability. In this review, we discuss the use of several antigen/adjuvant cationic combinations. The discussion involves antigen assembled to 1) cationic lipids, 2) cationic polymers, 3) cationic lipid/polymer nanostructures, and 4) cationic polymer/biocompatible polymer nanostructures. Some of these cationic assemblies revealed good yet poorly explored perspectives as general adjuvants for vaccine design.

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Section: Assemblies Based On Cationic Polymersmentioning

confidence: 99%

Cationic Nanostructures for Vaccines Design

Carmona-Ribeiro

Betancourt

2020

Biomimetics

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“…Diethylaminoethyl (DEAE)dextran, a polycationic derivative containing DEAE groups linked to glucose, has been evaluated as a veterinary adjuvant for inactivated virus vaccines since the 1970s. Whole cell cholera Ag and DEAE-dextran were shown to enhance immune responses [118], while DEAE-dextran adjuvant, combined with whole-cell typhoid vaccine, was more effective by the active mouse protection test than TT-adjuvanted vaccine or Ag alone [119]. Dextran nanospheres with entrapped Ag and DEAE have also been used as adjuvants [117].…”

Section: Dextran and Biopolymer Combinationsmentioning

confidence: 99%

Biodegradable polymers for modern vaccine development

Bose

Kim

Chang

et al. 2019

Journal of Industrial and Engineering Chemistry

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A B S T R A C TMost traditional vaccines are composed either of a whole pathogen or its parts; these vaccines, however, are not always effective and can even be harmful. As such, additional agents known as adjuvants are necessary to increase vaccine safety and efficacy. This review summarizes the potential of biodegradable materials, including synthetic and natural polymers, for vaccine delivery. These materials are highly biocompatible and have minimal toxicity, and most biomaterial-based vaccines delivering antigens or adjuvants have been shown to improve immune response, compared to formulations consisting of the antigen alone. Therefore, these materials can be applied in modern vaccine development.

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“…It has a high charge density due to a high ratio of negatively charged sulfate to glucosyl residues which can increase loading of positively charged drugs such as doxorubicin 66 . Higher molecular weight diethylaminoethyl (DEAE) dextran is a polycationic polymer of dextran that has been applied to vaccines for foot-and-mouth disease and Venezuelan equine encephalomyelitis in mammals 67 . Additionally acetylated dextran in the form of microparticles have been explored as delivery platforms for vaccines.…”

Section: Dextranmentioning

confidence: 99%

Novel Cationic Pentablock Copolymers as a Nanovaccine Delivery Platform

Adams

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We report the synthesis of a family of amphiphilic pentablock polymers with different cationic blocks and with controlled architectures as potential vaccine carriers for subunit vaccines. The temperature and pH-dependent micellization and gelation of these pentablock copolymers can provide a depot for sustained protein and gene delivery. The amphiphilic central triblock promotes cellular endocytosis, good gene

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Adjuvant effect of DEAE-dextran on cholera vaccines

Cited by 21 publications

References 15 publications

Cationic Nanostructures for Vaccines Design

Cationic Nanostructures for Vaccines Design

Biodegradable polymers for modern vaccine development

Novel Cationic Pentablock Copolymers as a Nanovaccine Delivery Platform

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