Adjuvant effect of a yeast glucan in vaccines against furunculosis in Atlantic salmon (Salmo salar L.)

Rørstad, Gunnar; Aasjord, Per; Robertsen, Børre

doi:10.1006/fsim.1993.1018

Cited by 82 publications

(37 citation statements)

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“…and salmon challenged 3-555 46 weeks after vaccination. Vaccines supplemented with ß-glucan induced significantly 556 higher protection against furunculosis than vaccines without this adjuvant [70], but ß-557 glucan alone did not result in protection after 11 weeks. In another study, ß-glucan-adjuvanted vaccines against furunculosis seemed to give protection at an early time-559 point after vaccination (6 weeks), but no protection was seen after 3 and 6 months [41].…”

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Adjuvants and immunostimulants in fish vaccines: Current knowledge and future perspectives

Tafalla¹,

Bøgwald

Dalmo

2013

Fish & Shellfish Immunology

237

142

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“…Yeast glucan (mainly a ß-1,3-D glucan) was included in a furunculosis vaccine 553 that consisted in a formalin-killed culture of A. salmonicida and V. salmonicida [70].…”

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confidence: 99%

Adjuvants and immunostimulants in fish vaccines: Current knowledge and future perspectives

Tafalla¹,

Bøgwald

Dalmo

2013

Fish & Shellfish Immunology

237

142

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“…Several researches about the contribution of adjuvant to immune response of fish have been reported (Rorstad et al, 1993;Aakre et al, 1994;Chu, 2006;Jiao et al, 2010). Most of them proved that adjuvant could enhance immune response through increasing activity of leukocyte and plasmocyte as well as speeding up production of specific antibody (Williams et al, 1989;Robertsen et al, 1990).…”

Section: Experimental Challengementioning

confidence: 99%

The immune-adjuvant effect and safety of recombinant CC chemokine 1 (rRbCC1) in rock bream, Oplegnathus fasciatus

Kwon¹,

Kim²,

Hwang³

et al. 2013

Journal of fish pathology

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Adjuvants are immune enhancers that are often used in vaccination to augment the immune response of a vaccine, thereby enhancing the protective immunity against the targeted disease. In the present study, we used the recombinant protein, such as rRbCC1, this protein was produced from rock bream CC chemokine 1. To verify the adjuvant effects of this recombinant protein, the immune responses of rock bream to Streptococcus iniae (S. iniae) FKC vaccination, which alone or in combination with recombinant protein was analyzed and then also performed experimental challenge with live S. iniae. The result of serum agglutination titres was showed relatively low levels however, the efficacy of FKC vaccine still conferred protection against S. iniae. Moreover, the adverse effects result showed that no statistically significant difference was revealed between high concentration injected and non-injected fish groups, generally. The relative percent survival (RPS) of FKC + recombinant vaccination group was significantly higher than that of vaccinated group with FKC alone. After experimental challenge to the rock bream by injection with live bacteria (S. iniae), the FKC + rRbCC1 vaccination group was showed 87.0% RPS, however, the RPS of FKC alone vaccination was 68.2%. The results indicated that the recombinant protein as an adjuvant had a clear synergism to injection vaccine of rock bream.

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“…Barley has been included in feed for animal species, mainly due to its high β-glucan content. β-glucans are commonly used as a vaccine adjuvant [5] and as immunostimulatory feed ingredient [6].Histological studies have been carried out using different bioactive products such as β-glucans [7] howeverscarce information is available regarding the effect on diet of whole cereal grains. The aim of this study was to evaluate the effect of barley on liver morphology and histology parameters.…”

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Effect of Barley on Liver Histology of Rainbow Trout, Oncorhynchus mykiss

Gil¹

2017

JAMB

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Submit Manuscript | http://medcraveonline.com are low in antinutritional factors [4]. Barley has been included in feed for animal species, mainly due to its high β-glucan content. β-glucans are commonly used as a vaccine adjuvant [5] and as immunostimulatory feed ingredient [6].Histological studies have been carried out using different bioactive products such as β-glucans [7] howeverscarce information is available regarding the effect on diet of whole cereal grains. The aim of this study was to evaluate the effect of barley on liver morphology and histology parameters. Material and MethodsFish grew in a recirculation system and fed 4 experimental diets [8] with increasing barley levels (0-16%) were used. Groups of 25 fish (average weight 128 g) were housed in 20 cylindrical fibreglass tanks (four per treatment). The trial lasted 78 days and was conducted in a freshwater recirculating system (RAS). At the end of the growth trial three fish livers per tank were collected. Livers were preserved in phosphate buffered formalin (4% pH 7.4). Three sections were obtained from each liver (two transversal and one longitudinal). For histological analysis, 4 μm tissue slices were stained with hematoxylin-eosin. Liver slices were evaluated for the infiltration of perpancreatic fat, hepatocytes area and length and presence of lymphocytes foci. This evaluation was carried out individually for each sample. Microphotographs were taken using a Nikon Microphot-FXA microscope and Olympus DP50 camera. Liver photographs (100X) were used to measure the area and maximum (L max ) and minimum (L min ) lengths of randomly selected hepatocytes passing through nucleus. For each fish, 15 hepatocytes were measured. All measurements were analysed using Image Pro ® Plus software (media Cybernetics, Inc.; MD, USA).Statistical analysis was performed using SAS version 9 (SAS Institute Inc., Cary, North Carolina, USA). When the variances were not normally distributed, the Kruskall-Wall is non-parametric test was applied to the data and the multiple comparison procedure to find non-paramentric pair differences were contrasted by Dunns test. The infiltration of perpancreatic fat and the presence of lymphocytes foci were analysed using the CATMOD procedure, and the significance was determined using a chi-square test at p<0.05.The study complied with European Union Council Directive 2010/63/UE, which lays down minimum standards for the protection of animals and Spanish National Legislation (Spanish Royal Decree 53/2013) and approved by Animal Ethics Committee of ITACyL. Results and DiscussionHistological analysis of the fish fed diets containing increasing barley levels exhibited morphological changes, unlike results obtained of rearing and quality parameters [8]. Liver cell vacuolization was significantly lower on fish fed 16B diets than AbstractThis study investigated the effects of the incorporation of barley instead of wheat to study fish growth and biometrics parameters, body composition, retention efficiency and liver histology of rainbow trout ...

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Adjuvant effect of a yeast glucan in vaccines against furunculosis in Atlantic salmon (Salmo salar L.)

Cited by 82 publications

References 0 publications

Adjuvants and immunostimulants in fish vaccines: Current knowledge and future perspectives

Adjuvants and immunostimulants in fish vaccines: Current knowledge and future perspectives

The immune-adjuvant effect and safety of recombinant CC chemokine 1 (rRbCC1) in rock bream, Oplegnathus fasciatus

Effect of Barley on Liver Histology of Rainbow Trout, Oncorhynchus mykiss

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