Adjuvant effect of a natural TLR4 ligand on dendritic cell-based cancer immunotherapy

Pleurotus ferulae water extract enhances the maturation and function of murine bone marrow-derived dendritic cells through TLR4 signaling pathway

“…The suboptimal maturation of DCs, which expressed low levels of co-stimulatory and MHC molecules and Th1-polarizing cytokine IL-12, is the one of the reason that caused the limited success of DCbased vaccine in clinical trials [39][40][41]. It has reported that extracts of herbal medicines can enhance anti-tumor immune responses through promoting the maturation and function of DCs [14][15][16][17]. Here, we found that PFWE not only enhanced the maturation of DCs and but also increased the production of IL-12.…”

“…Elluru et al [16] showed that aqueous extracts from Viscum album stimulate the maturation and activation of human DCs, which may facilitate anti-tumoral immune responses. Kim [17] reported that angelan, a natural TLR4 ligand, enhances the maturation and migration of DCs to increase anti-tumor activity. Pleurotus ferulae (PF) is an edible mushroom with high nutritional value and significant pharmacological properties, which grows on the living rhizome trunks of Ferula asafoetida in the Gobi desert and is mainly distributed in Xinjiang, China.…”

Complex evaluation of human monocyte‐derived dendritic cells for cancer immunotherapy

“…Other TLR4 ligands have been tested recently to obtain DC with favourable characteristics [25,28,42]. Further exploration of the possible interchangeability of LPS and these LPS analogues ( e.g .…”

A polysaccharide isolated from Pueraria lobata enhances maturation of murine dendritic cells

“…MAPK and NF-B are involved in TLR4-downstream signaling and play a major role in DC maturation [23]. Therefore, we examined whether MAPK and NF-B signaling was activated in PLP-treated DCs.…”