Adjuvant Disease-Prevention with Complete Freund's Adjuvant and with Mineral Oil Alone

Mycobacterium

“…Jolles et al and Migliore (152) have confirmed the finding of Tanaka (1138) that acetylation of wax D eliminates its arthritogenic properties and have made the further observation that animals primed with acetylated wax D in oil are protected against subsequent challenge against nonacetylated wax D in oil. Cozine et al (267) have used an adjuvant disease model in Holtzman rats in which the inducing dose is given at 28 days. They have found that pretreatment of the animals with Mycobacterium smegmatis (butyricum) in mineral oil (either 12.5-or 50-,g doses) protected them against induction of adjuvant disease 28 days later.…”