Adjuvant chemotherapy of childhood posterior fossa ependymoma: Cranio-spinal irradiation with or without adjuvant CCNU, vincristine, and prednisone: A Childrens Cancer Group study

Evans, Audrey E.; Anderson, James R.; Lefkowitz-Boudreaux, Ilene B.; Finlay, Jonathan L.

doi:10.1002/(sici)1096-911x(199607)27:1<8::aid-mpo3>3.0.co;2-k

Cited by 141 publications

(51 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7) However, most studies question the effect of chemotherapy. 4,14) Chemotherapy failed to improve the outcome in children with ependymoma. 4) In our case, the tumor arose in the supratentorial cerebral hemisphere and was anaplastic ependymoma (WHO grade III), which matches the previously reported characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…3) There are numerous prognostic factors such as resection extent, radiation strategy, chemotherapy, histological grade, location, and so on. [3][4][5][6]10,11,14,15,18) As can be expected, high grade anaplastic ependymoma carries a poorer prognosis than low grade.…”

Section: Discussionmentioning

confidence: 99%

“…4,14) Chemotherapy failed to improve the outcome in children with ependymoma. 4) In our case, the tumor arose in the supratentorial cerebral hemisphere and was anaplastic ependymoma (WHO grade III), which matches the previously reported characteristics. The very interesting characteristic of our case is that recurrence only occurred in the ipsilateral hemisphere and extracranial metastasis was observed only at the ip-M. Kinoshita et al…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Long-Term Control of Recurrent Anaplastic Ependymoma With Extracranial Metastasis: Importance of Multiple Surgery and Stereotactic Radiosurgery Procedures-Case Report-

Kinoshita

Izumoto

Kagawa

et al. 2004

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

An 11-year-old Japanese girl presented with a right frontal lobe anaplastic ependymoma. The tumor was removed surgically. However, she developed a secondary lesion and extracranial metastasis in the cervical lymph node. In total, she underwent eight intracranial tumor removal procedures, five stereotactic radiosurgeries with six targets, and five cervical lymph node removal surgeries during the course of 7 years. She is currently alive with a good quality of life, and has no major neurological deficits except right facial nerve palsy. The combination of surgery and radiosurgery can achieve local control of anaplastic ependymoma. Multiple surgery or radiosurgery procedures can result in good outcome, if the tumor does not involve crucial structures, even if extracranial metastasis occurs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Long-Term Control of Recurrent Anaplastic Ependymoma With Extracranial Metastasis: Importance of Multiple Surgery and Stereotactic Radiosurgery Procedures-Case Report-

Kinoshita

Izumoto

Kagawa

et al. 2004

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

show abstract

“…41 Multiple agents including carboplatin, cisplatin, etoposide, idarubicin, ifosfamide, irinotecan, carmustine, and TMZ have been studied in phase II trials with modest response. 162 Multi-agent strategies (e.g., lomustine, prednisone, and vincristine), 163 as well as high-dose chemotherapy with stem cell rescue have been disappointing and can not be generally recommended. 164 Chemotherapy to date is used as an adjuvant therapy in patients with residual or recurrent disease, but cannot be recommended as standard treatment.…”

Section: Chemotherapymentioning

confidence: 99%

Pediatric Brain Tumors: Current Treatment Strategies and Future Therapeutic Approaches

2009

View full text Add to dashboard Cite

Summary:Pediatric CNS tumors are the most common solid tumors of childhood and the second most common cancer after hematological malignancies accounting for approximate 20 to 25% of all primary pediatric tumors. With over 3,000 new cases per year in the United States, childhood CNS tumors are the leading cause of death related to cancer in this population. The prognosis for these patients has improved over the last few decades, but current therapies continue to carry a high risk of significant side effects, especially for the very young. Currently a combination of surgery, radiation, and chemotherapy is often used in children greater than 3 years of age. This article will outline current and future therapeutic strategies for the most common pediatric CNS tumors, including primitive neuroectodermal tumors such as medulloblastoma, as well as astrocytomas and ependymomas.

show abstract

“…Chemotherapy has been used in an effort to delay irradiation and hopefully improve outcome in young children. A North American Childrens Cancer Group randomized trial in the 1980s (CCG-942) that evaluated adjuvant chemotherapy with lomustine, vincristine, and prednisone after surgery and irradiation failed to show any difference in OS when compared to irradiation alone; craniospinal irradiation (36Gy) with primary site boost (54 Gy) was administered to all patients [20]. The studies undertaken to delay chemotherapy in young children have generally shown poor success rates [9,[21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Supratentorial ependymoma in children: To observe or to treat following gross total resection?

Venkatramani

Dhall

Patel

et al. 2011

Pediatric Blood & Cancer

Self Cite

View full text Add to dashboard Cite

BackgroundThe standard treatment for ependymoma is surgical resection followed by postoperative irradiation to the local site. The role of radiation therapy in completely resected supratentorial ependymoma has been questioned over the past two decades.ProcedureRetrospective review of the medical records of all consecutively diagnosed supratentorial ependymoma patients at Children's Hospital Los Angeles between January 1999 and December 2009.ResultsTen patients (three females) were included. The median age at presentation was 5.6 years (range 1.8–15.6 years). Reviewed histology was anaplastic ependymoma in seven patients and cellular ependymoma in three patients. Gross total resection was achieved in six patients; five were observed and one received chemotherapy. In the four patients who underwent subtotal resection, one was observed, two received local irradiation and one received irradiation and chemotherapy. The median length of follow up was 43 (range 22–81) months. Four relapses were observed; two patients who underwent initial gross total resection. All patients who underwent gross total resection were alive at the time of preparation of this article. The 5‐year progression‐free and overall survival rates were 53 ± 19% and 86 ± 13% respectively.ConclusionsRadiation therapy was avoided in five patients following gross total resection, four of whom had anaplastic histology. In some children with completely resected supratentorial ependymoma, surgery alone may be an acceptable treatment option. Pediatr Blood Cancer 2012; 58: 380–383. © 2011 Wiley Periodicals, Inc.

show abstract

Adjuvant chemotherapy of childhood posterior fossa ependymoma: Cranio-spinal irradiation with or without adjuvant CCNU, vincristine, and prednisone: A Childrens Cancer Group study

Cited by 141 publications

References 13 publications

Long-Term Control of Recurrent Anaplastic Ependymoma With Extracranial Metastasis: Importance of Multiple Surgery and Stereotactic Radiosurgery Procedures-Case Report-

Long-Term Control of Recurrent Anaplastic Ependymoma With Extracranial Metastasis: Importance of Multiple Surgery and Stereotactic Radiosurgery Procedures-Case Report-

Pediatric Brain Tumors: Current Treatment Strategies and Future Therapeutic Approaches

Supratentorial ependymoma in children: To observe or to treat following gross total resection?

Contact Info

Product

Resources

About