Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: Report of intergroup study 0034

Laramore, George E.; Scott, Charles; Al‐Sarraf, Muhyi; Haselow, Robert E.; Ervin, Thomas J.; Wheeler, Richard; Jacobs, John R.; Schuller, David E.; Gahbauer, R.; Schwade, James G.; Campbell, Bruce H.

doi:10.1016/0360-3016(92)90642-u

Cited by 386 publications

(183 citation statements)

References 13 publications

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“…Because the overwhelming majority of locoregional disease recurrences occur within the first 2 years, it is unlikely that the conclusions of the current study will change significantly with further follow-up. 34 In conclusion, the results of the current study confirm the contributions of PET/CT in the early diagnosis of disease recurrence and second primary tumors after RT for head and neck cancer. Whether this ultimately translates into improved survival requires further study.…”

Section: Discussionsupporting

confidence: 82%

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Kao

Genden

et al. 2009

Cancer

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Nitroxyl radicals were used as functionalizing agents during the free radical postreactor modification process of polyolefins carried out in the melt. The 4‐hydroxy‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl (HO‐TEMPO) and the 4‐benzoyloxy‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl (BzO‐TEMPO) free radicals were successfully grafted onto a polyethylene‐based material (ethylene‐co‐1‐octene copolymer) by coupling reaction with polymer macroradicals; these last were formed by H‐abstraction through peroxide addition. The macromolecular structure of the functionalized polyolefins was assessed by 1H‐NMR, FTIR spectroscopy, and SEC measurements which were used to evidence the grafting site, to evaluate the grafting level and to highlight the occurrence of chain extension through crosslinking side reactions. Indeed the use of proper model compounds allowed the preparation of accurate FTIR calibration curves for the quantitative determination of the functionalization degree. Besides the high temperature SEC analysis highlighted that this fast and simple coupling reaction between macroradicals and nitroxyl free radicals grants the grafting of functionalities onto the polyolefin backbone by contemporarily preventing the side reactions liable of the structure and MW modification of the pristine polymer. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011

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Section: Discussionsupporting

confidence: 82%

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Kao

Genden

et al. 2009

Cancer

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“…The regimen of adjuvant chemotherapy in randomized studies consisted of three courses of intravenous low-dose CDDP-based regimen every 6 weeks (Ervin et al, 1987), monthly intravenous CDDP (80 mg m À2 ) alone for 6 months (Jacobs and Makuch, 1990), three courses of intravenous CDDP (100 mg m À2 ) with 5-day continuous infusion of 5-FU at 1000 mg m À2 day À1 (Laramore et al, 1992) and 18 courses of intravenous methotrexate (250 mg m À2 ) followed by 5-FU (600 mg m À2 ) with leucovorin rescue over 6 months on an outpatient basis (Johnson et al, 1996). A few studies suggested survival benefits (Ervin et al, 1987;Johnson et al, 1996) and a decrease in the incidence of distant metastases with adjuvant chemotherapy (Jacobs and Makuch, 1990;Laramore et al, 1992). The Head and Neck Contracts Study group showed that adjuvant chemotherapy, while reducing distant metastases, does not improve survival significantly in the total of cases studied; however, a significant survival advantage with adjuvant chemotherapy was detected for oral cavity cancer and for N2 disease using a subset analysis (Jacobs and Makuch, 1990).…”

Section: Discussionmentioning

confidence: 99%

“…Adjuvant chemotherapy might be a one of the candidates. Several randomised trials of adjuvant (maintenance) chemotherapy in advanced SCCHN have been done (Ervin et al, 1987;Jacobs and Makuch, 1990;Laramore et al, 1992;Johnson et al, 1996). A few randomised trials regarding adjuvant chemotherapy reported the possibility of survival benefits (Ervin et al, 1987;Johnson et al, 1996).…”

mentioning

confidence: 99%

Randomized scheduling feasibility study of S-1 for adjuvant chemotherapy in advanced head and neck cancer

et al. 2005

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The purpose of this study was to determine the feasible adjuvant therapy administration schedule of S-1 for locoregionally advanced squamous cell carcinoma of the head and neck (SCCHN). Patients receiving definitive treatments were randomly assigned to either arm A (51 cases) receiving oral S-1 of 2-week administration followed by 1-week rest for 6 months, or arm B receiving S-1 of 4-week administration followed by 2-week rest for 6 months. Planned treatment was given in 40% of patients in arm A and 29% in arm B. The cumulative rates of the relative total administration dose of S-1 at 100% were 54.9% (95% CI: 40.1 -69.7%) in arm A and 34.3% (95% CI: 21.1 -47.4%) in arm B, respectively (P ¼ 0.054). Adverse events were recorded in 41 patients (82.0%) in arm A and 48 patients (94.1%) in arm B (P ¼ 0.060). The incidences of diarrhoea (10 vs 28%; Po0.05) and skin toxicities (18 vs 37%; Po0.05) were significantly higher in arm B. One-year disease-free survival was similar in both arms: arm A 81.2% (95% CI: 70.0 -92.4%); arm B 77.0% (95% CI: 65.0 -89.0%). The schedule of 2-week administration followed by 1-week rest seems to be more feasible for oral 6-month administration of S-1 in adjuvant chemotherapy of locoregionally advanced SCCHN.

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“…Various studies shows that many local or regional disease, recurrence occur in 30 percent of patients, and distant metastases occurs in 25 percents. 4 Patients who have two or more regional lymph nodes involved, extracapsular spread of disease, or microscopically involved mucosal margins of resection have particularly high rates of local recurrence (27 to 61 percent) and distant metastases (18 to 21 percent) and a high risk of death (five-year survival rate, 27 to 34 percent).…”

Section: Introductionmentioning

confidence: 99%

Treatment outcome of postoperative radiotherapy for squamous cell carcinoma of the head and neck

Ghori

Sohaib

Tiwari

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Though early stage malignancy of head and neck can be cured by surgery or radiotherapy, cure of patients with locally advanced disease continues to pose a therapeutic challenge. Loco regional failure is the major cause of death in head and neck cancer. As the cure of locally advance head and neck cancer is less than expectation, a combined modality approach is generally used in these type of patients. The combination of surgery, radiotherapy and chemotherapy can improve outcome in locally advance head and neck cancer.Methods: This observational study reviewed cancer patients reported in our hospital with the following inclusion criteria: primary head and neck cancer, treatment with radical surgery, and multiple nodal metastases. The prescribed dose of postoperative radiotherapy was 60–66 Gy. Patient characteristics, treatment parameters and clinical outcome were recorded. Results: The primary end point was overall survival, and the secondary endpoint was disease status.Conclusions: Concurrent postoperative administration of chemotherapy and radiotherapy is a way to intensify treatment for resectable high-risk head and neck tumors.

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Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck: Report of intergroup study 0034

Cited by 386 publications

References 13 publications

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

The diagnostic and prognostic utility of positron emission tomography/computed tomography‐based follow‐up after radiotherapy for head and neck cancer

Randomized scheduling feasibility study of S-1 for adjuvant chemotherapy in advanced head and neck cancer

Treatment outcome of postoperative radiotherapy for squamous cell carcinoma of the head and neck

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