“…For example, it may be difficult to prevent sweetener use over a long period of time in a participant who has been randomized to a no sweetener group. Out of dozens of works dealing with intense sweeteners' role in human nutrition, the meta-analysis addressed 15 RCTs with 24-h intake data (Porikos et al, 1977(Porikos et al, , 1982Foltin et al, 1988Foltin et al, , 1990Evans, 1989Evans, , 1992Mattes, 1990a;Tordoff and Alleva, 1990b;Naismith and Rhodes, 1995;Blackburn et al, 1997;Gatenby et al, 1997;Lavin et al, 1997;Reid and Hammersley, 1998;Raben et al, 2002;Van Wymelbeke et al, 2004) and nine RCTs with body weight data (Porikos et al, 1977(Porikos et al, , 1982Tordoff and Alleva, 1990b;Kanders et al, 1990;Naismith and Rhodes, 1995;Blackburn et al, 1997;Gatenby et al, 1997;Reid and Hammersley, 1998;Raben et al, 2002). These RCTs showed considerable variations in their design, study population, duration and type of control.…”