Adjustment Disorder

Casey, Patricia

doi:10.2165/11311000-000000000-00000

Cited by 70 publications

(15 citation statements)

References 60 publications

(46 reference statements)

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“…The results of the screening study demonstrated the prevalence of a decrease in stress resistance and subjective deterioration in all age groups with an increase to 50.9% in the age group 51-65 years. The data obtained are comparable with international studies [3], [7], [8], [22], [23]. These studies emphasize the importance of assessing the condition of patients with the AD and choosing the safest therapy.…”

Section: Resultssupporting

confidence: 83%

“…The persistent or chronic AD can last more than 6 months, especially if the stressor continues, for example, in case of unemployment. Many publications note that AD is most often (up to 37%) observed in primary health care facilities and outpatient psychiatric practice [7], [8]. The AD has high co-morbidity with depression, anxiety, mixed anxiety-depressive states, behavioral disorders, substance abuse.…”

Section: Signi Icant Deterioration In Social Professional or Other Imentioning

confidence: 99%

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The effectiveness of selank in the treatment of adjustment disorder

Verbenko

2018

PMGP

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Background Adjustment disorder (AD) is one of the most common mental disorders. Considering the social and economic situation in Ukraine at present, in almost 50% of the population, there are non-psychotic mental health disorders, and this number tends to increase. Individual risk factors that are particularly important for the AD development include the experience of a significant stress in childhood, problems with mental health in the past, difficult life circumstances, etc. At the same time, pathogenetically approaches to AD therapy are not fully understood. Pathogenetically oriented therapy of AD should be based on neurotransmitter causes and systemic therapeutic approach. The neurometabolic, anxiolytic, and psycho-stimulating action of the regulatory peptide allows it to be used in the therapy of psychogenic adaptation disorders. Methods Clinical manifestations of the AD were studied in different age groups - 21-34 years (n=153), 35-50 years (n=257), 51-65 years (n=167) using the Patient Health Questionnaire (PHQ) and Questionnaire of Stress Resistance (QSR). For the study on the effectiveness of the selank (a synthetic analogue of the immunomodulatory peptide tuftsin) were included 30 patients with the AD. Main (experimental group) received selank for two weeks; the control group didn’t receive any treatment (wait list). Patients were monitored for additional two weeks after the treatment with an assessment at the end of follow-up. Results According to the study results, selank significantly reduced PHQ score in patients with AD compared to control group. PHQ scores in the selank group after 2 weeks of follow-up were significantly lower for somatic symptoms (mean score 1.2 vs. 3.6; p<0.05), nutritional problems (0.1 vs. 3.4; p<0.05), and alcohol misuses (0.3 vs. 1.5; p<0.05). Conclusion The use of the synthetic analogue of the immunomodulatory peptide tuftsin has a therapeutic effect on the somatic and mental symptoms of the adjustment disorder.

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Section: Resultssupporting

confidence: 83%

Section: Signi Icant Deterioration In Social Professional or Other Imentioning

confidence: 99%

The effectiveness of selank in the treatment of adjustment disorder

Verbenko

2018

PMGP

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“…Personal circumstances and context of the stressor, relation between symptom severity and stressor, persistence beyond the expected time period, cultural norms for emotional response/expression and duration and severity of dysfunction can be useful guide to make a diagnosis of adjustment disorder. [3] Major depression should be considered as the diagnosis when symptoms meet the diagnostic threshold of depression. Exacerbation of maladjustment in personality disorders when faced with severe stress can result in symptoms of adjustment disorder.…”

Section: Current Nosological Statusmentioning

confidence: 99%

Adjustment Disorder: Current Diagnostic Status

Patra¹,

Sarkar²

2013

Indian Journal of Psychological Medicine

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Adjustment disorder is a common diagnosis in psychiatric settings and carries a significant rate of morbidity. However, diagnostic criteria are vague and not much helpful in clinical practice. Also there has been relatively little research done on this disorder. In this article, we review the information that is available on the epidemiology, clinical features, validity, and current diagnostic status of adjustment disorder. In this article, the controversy surrounding the diagnosis is also highlighted. It also discusses the differential and comorbid diagnosis. The various recommendations for DSM-V and ICD-11 conclude the article.

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“…The other option of DSM-IV for emphasizing the role of stress in the clinical status of the patient lies in the use of specific diagnostic rubrics (acute stress disorder, posttraumatic stress disorder) or broad diagnoses (adjustment disorders). However, the category of adjustment disorders has displayed major conceptual and methodological flaws [6,7,8]. A major problem is the fact that it is an exclusion diagnosis (it cannot be applied in comorbidity with other psychiatric disorders) and overlaps with subthreshold manifestations of mood and anxiety disorders [9,10,11,12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Clinical Assessment of Allostatic Load and Clinimetric Criteria

Fava

Guidi²,

Semprini³

et al. 2010

Psychother Psychosom

112

102

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The concept of allostasis emphasizes that healthy functioning requires continual adjustments to the internal physiological milieu. Allostatic load reflects the cumulative effects of stressful experiences in daily life. When the cost of chronic exposure to fluctuating or heightened neural or neuroendocrine responses exceeds the coping resources of an individual, allostatic overload ensues. So far these issues have been addressed only on pathophysiological terms that do not find application in clinical settings. However, several features that have been described in psychosomatic research may allow the assessment of allostatic load on clinical grounds. Clinimetric criteria for the determination of allostatic overload are suggested. They are based on: (a) the presence of a stressor exceeding individual coping skills, and (b) clinical manifestations of distress. They may provide specification to the fourth axis of DSM, may supplement the Diagnostic Criteria for Psychosomatic Research, and may help discriminate neuroendocrine patterns with important clinical and research implications. A state of allostatic overload is frequently associated with alterations in biological markers and calls for a close medical evaluation of the patient’s condition. The ultimate goal is to be able to prevent or decrease the negative impact of excessive stress on health.

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Adjustment Disorder

Cited by 70 publications

References 60 publications

The effectiveness of selank in the treatment of adjustment disorder

The effectiveness of selank in the treatment of adjustment disorder

Adjustment Disorder: Current Diagnostic Status

Clinical Assessment of Allostatic Load and Clinimetric Criteria

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