Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: a meta-analysis

Thurnham, David I.; McCabe, Linda D; Haldar, Sumanto; Wieringa, Frank T.; Northrop-Clewes, Christine A.; McCabe, George P.

doi:10.3945/ajcn.2010.29284

Cited by 480 publications

(697 citation statements)

References 33 publications

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“…‡Fe deficiency is defined as serum ferritin <15 ng/ml (49) . §Adjusted for elevated C-reactive protein (>10 mg/l) or elevated α 1 -acid glycoprotein (>1 g/l) by mathematical correction (18,19) . ||Fe-deficiency anaemia is defined as Hb <11·5 g/dl plus serum ferritin <15 ng/ml in children aged 6-11 years and as Hb <12 g/dl plus serum ferritin <15 ng/ml in children aged 12-14 years (49) .…”

Section: Resultsmentioning

confidence: 99%

“…Adjusting for infection Serum ferritin was adjusted for infection by estimating biomarkers of infection: CRP and AGP. The adjustment of serum ferritin for elevated CRP (>10·0 mg/l) (15)(16)(17) and AGP (>1·0 g/l) was done by calculating the correction factors following the methods described by Thurnham et al (18) and Engle-Stone et al (19) . Similarly correction factors for serum retinol and Zn were calculated and used to adjust the retinol and Zn levels in serum.…”

Section: Biochemical Analysesmentioning

confidence: 99%

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Determinants of iron status and Hb in the Bangladesh population: the role of groundwater iron

Rahman

Ahmed

Rahman

et al. 2016

Public Health Nutr.

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Objective: Using data from the national micronutrients survey 2011-2012, the present study explored the determinants of Fe status and Hb levels in Bangladesh with a particular focus on groundwater Fe. Design: Cross-sectional study conducted at the nationwide scale. Settings: The survey was conducted in 150 clusters, fifty in each of the three strata of rural, urban and slum. Subjects: Three population groups: pre-school age children (6-59 months; PSAC), school age children (6-14 years; SAC) and non-pregnant non-lactating women (15-49 years; NPNLW). Results: National prevalence of Fe deficiency was 10·7 %, 7·1 % and 3·9-9·5 % in PSAC, NPNLW and SAC, respectively. Prevalence of anaemia was 33·1 % (PSAC), 26·0 % (NPNLW) and 17·1-19·1 % (SAC). Multivariate regression analyses showed that the area with 'predominantly high groundwater Fe' was a determinant of higher serum ferritin levels in NPNLW (standardized β = 0·19; P = 0·03), SAC (standardized β = 0·22; P = 0·01) and PSAC (standardized β = 0·20; P = 0·03). This area also determined higher levels of Hb in PSAC (standardized β =

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Section: Resultsmentioning

confidence: 99%

Section: Biochemical Analysesmentioning

confidence: 99%

Determinants of iron status and Hb in the Bangladesh population: the role of groundwater iron

Rahman

Ahmed

Rahman

et al. 2016

Public Health Nutr.

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“…A number of biomarkers of iron status have been developed (Mei et al 2005;Beard et al 2006Beard et al , 2007Yang et al 2008;Ayoya et al 2010;Thurnham et al 2010). Of these, the hemoglobin (Hb) concentration in the blood is commonly used to estimate the prevalence of iron deficiency.…”

Section: Biomarkers For Assessing Nutritional Statusmentioning

confidence: 99%

Nutritionally Enhanced Staple Food Crops

Dwivedi

Sahrawat

Kedar

et al. 2012

Plant Breeding Reviews

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“…yAdjusted for elevated CRP . 5 mg/l (35) . JDefined as concurrent anaemia and Fe deficiency (SF , 12 mg/l or sTfR .…”

Section: Discussionmentioning

confidence: 97%

“…Body Fe content was calculated using the formula (33) (34) . To adjust SF concentration for those children with elevated CRP (.5 mg/l), a correction factor (0?67) was used to yield an adjusted value representative of a child without acute inflammation (35) .…”

Section: Discussionmentioning

confidence: 99%

Simulation of the effect of maize porridge fortified with grain amaranth or micronutrient powder containing NaFeEDTA on iron intake and status in Kenyan children

Macharia-Mutie

Omusundi

Mwai

et al. 2012

Public Health Nutr.

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Objective: Simulating the probable impact of grain amaranth and highly absorbable, low-Fe micronutrient powder (MNP) on Fe status in a potential target population is an essential step in choosing and developing an appropriate actual intervention. Design: We simulated the potential effect of fortifying maize porridge with grain amaranth or MNP on the prevalence of inadequate Fe intake and Fe deficiency using data from two cross-sectional surveys. In the first survey (2008), dietary intake data were collected by two 24 h recalls (n 197). Biochemical data (n 70) were collected in the second survey (2010). A simulation with daily consumption for 80 d of non-fortified maize porridge (60 g of maize flour), amaranth-enriched porridge (80 g of grain amaranth-maize flour, 70:30 ratio) or maize porridge fortified with MNP (2?5 mg Fe as NaFeEDTA) was done. Setting: Mwingi District, Kenya. Subjects: Pre-school children aged 12-23 months. Results: Prevalence of anaemia, Fe deficiency and Fe-deficiency anaemia was 49 %, 46 % and 24 %, respectively. Consumption of non-fortified, amaranth-enriched and MNP-fortified maize porridge was estimated to provide a median daily Fe intake of 8?6 mg, 17?5 mg and 11?1 mg, respectively. The prevalence of inadequate Fe intake was reduced to 35 % in the amaranth-enriched porridge group and 45 % in the MNP-fortified porridge group, while ferritin concentration was increased in both (by 1?82 (95 % CI 1?42, 2?34) mg/l and 1?80 (95 % CI 1?40, 2?31) mg/l, respectively; P , 0?005) compared with the non-fortified maize porridge group, resulting in a decreased prevalence of Fe deficiency (27 %) in the two fortification groups. Conclusions: Addition of grain amaranth or low-Fe MNP to maize-based porridge has potential to improve Fe intake and status in pre-school children.

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Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: a meta-analysis

Abstract: Measures of both APP and CRP are needed to estimate the full effect of inflammation and can be used to correct ferritin concentrations. Few differences were observed between age and sex subgroups.

Cited by 480 publications

References 33 publications

Determinants of iron status and Hb in the Bangladesh population: the role of groundwater iron

Determinants of iron status and Hb in the Bangladesh population: the role of groundwater iron

Nutritionally Enhanced Staple Food Crops

Simulation of the effect of maize porridge fortified with grain amaranth or micronutrient powder containing NaFeEDTA on iron intake and status in Kenyan children

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