Adjusting Incidence Estimates with Laboratory Test Performances: A Pragmatic Maximum Likelihood Estimation-Based Approach
Yingjie Weng,
Lu Tian,
Derek Boothroyd
et al.
Abstract:Understanding the incidence of disease is often crucial for public policy decision-making, as observed during the COVID-19 pandemic. Estimating incidence is challenging, however, when the definition of incidence relies on tests that imperfectly measure disease, as in the case when assays with variable performance are used to detect the SARS-CoV-2 virus. To our knowledge there are no pragmatic methods to address the bias introduced by performance of labs in testing for the virus. In the setting of a longitudina… Show more
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