Adjusting ferritin concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Namasté, Sorrel; Rohner, Fabian; Huang, Jin; Bhushan, Nivedita L.; Flores‐Ayala, Rafael; Kupka, Roland; Mei, Zuguo; Raj, Rahul; Williams, Anne; Raiten, Daniel J.; Northrop-Clewes, Christine A.; Suchdev, Parminder S.

doi:10.3945/ajcn.116.141762

Cited by 268 publications

(136 citation statements)

References 37 publications

(49 reference statements)

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“…However, none of the study's sample was eligible for exclusion. Participants were classified iron deficient (SF <15 μg/l or SF 15–70 μg/l and CRP >5 mg/l) otherwise normal ferritin levels ( 32 , 33 ) .…”

Section: Methodsmentioning

confidence: 99%

Serum ferritin levels are associated with frequent consumption of iron- and ascorbate-rich foods among women of childbearing age in Nandi County, Kenya

2022

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Information on consumption patterns of iron- and ascorbate-rich foods and their influence on iron status among women of childbearing age (WCA) is scarce in Kenya despite iron deficiency being rampant. The present study investigated consumption patterns of iron- and ascorbate-rich foods on iron status among WCA in Kapsabet Ward, Kenya. The study adopted a cross-sectional analytical design. A sample of 160 respondents was systematically selected proportionately in the eight villages. Consumption patterns of iron- and ascorbate-rich foods were assessed using a modified 7-d Food Frequency Questionnaire. Venous blood (2 ml) was drawn from participants. Serum ferritin and C-reactive proteins were measured by enzyme immunoassay. Consumption patterns of iron- and ascorbate-rich foods were analysed using descriptive statistics. Multivariable regression was conducted to investigate the association between iron- and ascorbate-rich foods consumption and iron status. Confounding variables such as consumption of foods high phytate levels, milk and milk products, recent major blood losses and parasitic infections were controlled for during analysis. The prevalence of iron deficiency among the WCA was 45⋅0 %. Iron-rich foods were rarely (<2 times/week) consumed by the respondents with the majority reporting infrequent consumption: meat (61⋅3 %), sardines (61⋅9 %), oranges (54⋅4 %) and fortified breakfast cereals (94⋅4 %), except for kale and beans. Iron- (iron-fortified porridge, meat, sardines, beans, amaranth and spider plants) and ascorbate- (oranges and mangoes) rich foods positively predicted (AOR = 4⋅851, P = 0⋅021) the normal iron status of WCA. WCA should consume above 2 intakes per week of each iron- and ascorbate-rich food for better iron status outcomes.

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Section: Methodsmentioning

confidence: 99%

Serum ferritin levels are associated with frequent consumption of iron- and ascorbate-rich foods among women of childbearing age in Nandi County, Kenya

2022

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“…We used correlation analysis to examine the relation between plasma selenium concentration and plasma concentrations of CRP and AGP, separately, at 36 wk of gestation. If there was a correlation (Spearman correlation P < 0.1) between markers of inflammation and plasma selenium concentration, the method described by the BRINDA (Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia) project was used to correct the selenium results for inflammation ( 29 ). Inflammation-corrected and non–inflammation-corrected plasma selenium results are presented.…”

Section: Methodsmentioning

confidence: 99%

Provision of Small-Quantity Lipid-Based Nutrient Supplements Increases Plasma Selenium Concentration in Pregnant Women in Malawi: A Secondary Outcome of a Randomized Controlled Trial

Haskell

Maleta

Jorgensen

et al. 2022

Current Developments in Nutrition

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Background Pregnant women in Malawi are at risk of selenium deficiency, which may have adverse effects on pregnancy outcomes. Interventions for improving selenium status are needed. Objectives The effect of provision of small-quantity lipid-based nutrient supplements (SQ-LNS) to Malawian women during pregnancy on their plasma selenium concentrations was assessed at 36 wk gestation. Methods Pregnant women (≤20 wk gestation) were randomized to receive daily either: 1) iron and folic acid (IFA); 2) multiple micronutrients (MMN; 130 µg selenium/capsule) or 3) SQ-LNS (130 µg selenium/20 g). Plasma selenium concentrations were measured by ICP-MS at baseline and after at least 16 wk of intervention (at 36 wk gestation) and compared by intervention group. Results At 36 wk gestation, median (Q1, Q3) plasma selenium concentrations (µmol/L) were 0.96 (0.73, 1.23), 0.94 (0.78, 1.18), and 1.01 (0.85, 1.28) in the IFA, MMN and SQ-LNS groups respectively. Geometric mean (GM) plasma selenium concentration was 5.4% (95%CI:1.8%, 9.0%) higher in the SQ-LNS group than in the MMN group and tended to be higher than in the IFA group (+4.2% (95%CI: 1.0%, 7.8%). The prevalence of adjusted plasma selenium concentrations < 1 µmol/L was 55.1%, 57.8% and 47.3% in the IFA, MMN, and SQ-LNS groups, respectively; it was lower in the SQ-LNS group than in the MMN group, OR = 0.44 (95%CI:0.24, 0.83), and tended to be lower than in the IFA group, OR = 0.54 (95%CI:0.29, 1.03). There was a significant interaction between baseline plasma selenium concentration and intervention group (P = 0.003). In the lowest tertile of baseline selenium concentrations, GM (95%CI) plasma selenium concentration was higher, and the prevalence of low values was lower in the SQ-LNS group compared to the MMN and IFA groups at 36 wk gestation (P ≤ 0.007). Conclusion Provision of SQ-LNS containing selenium to pregnant women can be an effective strategy for improving their selenium status. Clinicaltrials.gov identifier: NCT01239693.

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“…Even so, our findings suggest that, for the older age groups (12-23 months of age), using the more conservative IZiNCG upper limits, distribution of MNP on every other day may be a safer choice. Dietary strategies to improve nutrient adequacy 88 The results of our analysis confirm that dietary habits differ across the different geographical regions in Ethiopia due to differences in cultural practices between regions [60,61]. For instance, eggs were not in the list of foods consumed by children from the Amhara region, most likely because animal source foods are not consumed during the long fasting season.…”

Section: Discussionmentioning

confidence: 66%

“…CRP rises rapidly at the onset of infection and reaches maximum concentrations between 24 and 48 hours, whereas AGP may take 4-5 days to reach a plateau [58]. In our study, elevated CRP and AGP levels were taken into account using the internal regression correction approach [60] (Chapter 4), for intervention and non-intervention groups as suggested by the BRINDA study [61]. However, we speculate that it is still possible that the corrections might not have removed all the effects of the acute phase response on SF in this population.…”

Section: Discussionmentioning

confidence: 99%

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Optimizing young child nutrition in Ethiopia : the effectiveness, acceptance and risks of micronutrient powders

Hafebo

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Ageappropriate infant and young child feeding practices are associated with child nutrition in India: insights from nationally representative data. Matern Child Nutr. 2015;11(1):73-87. 28. WHO. Global strategy for infant and young child feeding. Geneva: World Health Organization; 2003. 29. WHO/UNICEF. Complementary feeding of young children in developing countries: a review of current scientific knowledge.

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Adjusting ferritin concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Cited by 268 publications

References 37 publications

Serum ferritin levels are associated with frequent consumption of iron- and ascorbate-rich foods among women of childbearing age in Nandi County, Kenya

Serum ferritin levels are associated with frequent consumption of iron- and ascorbate-rich foods among women of childbearing age in Nandi County, Kenya

Provision of Small-Quantity Lipid-Based Nutrient Supplements Increases Plasma Selenium Concentration in Pregnant Women in Malawi: A Secondary Outcome of a Randomized Controlled Trial

Optimizing young child nutrition in Ethiopia : the effectiveness, acceptance and risks of micronutrient powders

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