Adjusted poor weight gain for birth weight and gestational age as a predictor of severe ROP in VLBW infants

Aydemir, Özge; Sarikabadayi, Yusuf Unal; Aydemir, Cumhur; Tunay, Zühal Özen; Tök, Levent; Erdeve, Ömer; Oğuz, Şerife Suna; Uraş, Nurdan; Dilmen, Uğur

doi:10.1038/eye.2011.29

Cited by 42 publications

(28 citation statements)

References 20 publications

(17 reference statements)

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“…In addition to varieties in ROP rates in different populations. 19,20 This study is the first that investigates the association between Uu colonization and the development of ROP requiring treatment in preterm infants with BW r1250 g. Our results showed that repiratory tract Uu colonization in addition to BW, duration of MV, and PROM 418 h was independently associated with severe ROP. We demonstrated that persistent positive colonization for Uu was significantly associated with more than five-fold increase in the need for laser surgery.…”

Section: Discussionmentioning

confidence: 60%

The association between respiratory tract Ureaplasma urealyticum colonization and severe retinopathy of prematurity in preterm infants ≤1250 g

Оздемир

Sarı

Tunay³

et al. 2012

Eye

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Aim To evaluate the association between respiratory tract Ureaplasma urealyticum (Uu) colonization and development of retinopathy of prematurity (ROP) requiring treatment. Methods The infants with birthweight (BW) r1250 g born in a third-level neonatal intensive care unit between March 2009 and May 2010 were prospectively identified. Nasopharyngeal swabs for Uu colonization were taken in postnatal first 3 days. Culturepositive patients were reevaluated on the twelfth day by nasopharyngeal swabs for Uu. The primary outcome was to define whether there was an association between respiratory tract Uu colonization and severe ROP requiring treatment. Independent sample's t-test or Mann-Whitney U-test was used to compare continuous variables and Chi-square test or Fisher's exact test for categorical variables. Multivariate (backward) logistic regression analysis was performed to simultaneously measure the influence of the independent variables with ROP as the dependent variable. Results A total of 25 (12.1%) infants developed severe ROP requiring treatment among 206 infants who underwent ROP screening. Mean BW and gestational age of total cohort were 1013 ± 159 g and 27.9 ± 1.6 weeks, respectively. Multivariate analysis demonstrated that BW (OR: 0.64 (95% Cl 0.47-0.88); P ¼ 0.006), duration of mechanical ventilation (OR: 1.17 (95% Cl 1.06-1.28); P ¼ 0.001), premature rupture of membrane 418 h (OR: 3.83 (95% Cl 1.2-12.2); P ¼ 0.02), and Uu positivity in both cultures (OR: 5.02 (95% Cl 1.8-13.9); P ¼ 0.002) were independent risk factors for the development of severe ROP requiring treatment. Conclusions Respiratory tract colonization with Uu was independently associated with severe ROP requiring treatment.

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Section: Discussionmentioning

confidence: 60%

The association between respiratory tract Ureaplasma urealyticum colonization and severe retinopathy of prematurity in preterm infants ≤1250 g

Оздемир

Sarı

Tunay³

et al. 2012

Eye

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“…Currently, low weight gain after premature birth is widely accepted as a predictive factor for later development of ROP, being considered superior to BW and GA alone as predictors. [12][13][14][15][16][17][18] In addition, ROPScore also takes into account the use of oxygen in mechanical ventilation and the need for blood transfusions. All these risk factors are involved in the process of ROP development and can be easily identified by ophthalmologists during the initial ROP screening eye examination.…”

Section: Discussionmentioning

confidence: 99%

A predictive score for retinopathy of prematurity in very low birth weight preterm infants

Eckert

Filho

Maia

et al. 2011

Eye

102

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Aims This study describes the development of a score based on cumulative risk factors for the prediction of severe retinopathy of prematurity (ROP) comparing the performance of the score against the birth weight (BW) and gestational age (GA) in order to predict the onset of ROP. Methods A prospective cohort of preterm infants with BWp1500 g and/or GAp32 weeks was studied. The score was developed based on BW, GA, proportional weight gain from birth to the 6th week of life, use of oxygen in mechanical ventilation, and need for blood transfusions from birth to the 6th week of life. The score was established after linear regression, considering the impact of each variable on the occurrences of any stage and severe ROP. Receiver operating characteristic (ROC) curves were used to determine the best sensitivity and specificity values for the score. All variables were entered into an Excel spreadsheet (Microsoft) for practical use by ophthalmologists during screening sessions. Results The sample included 474 patients. The area under the ROC curve for the score was 0.77 and 0.88 to predict any stage and severe ROP, respectively. These values were significantly higher for the score than for BW (0.71) and GA (0.69) when measured separately. Conclusions ROPScore is an excellent index of neonatal risk factors for ROP, which is easy to record and more accurate than BW and GA to predict any stage ROP or severe ROP in preterm infants. The scoring system is simple enough to be routinely used by ophthalmologists during screening examination for detection of ROP.

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“…Patient selection for ROP screening is based on gestational age (GA) and birth weight (BW) as well as repeated eye examinations to find those who need laser treatment. The screening criteria, however, vary between developed and developing countries [2,3,4,5,6,7]. Furthermore, repeated eye examinations are associated with pain and stress for the immature infants [8].…”

Section: Introductionmentioning

confidence: 99%

The Use of the WINROP Screening Algorithm for the Prediction of Retinopathy of Prematurity in a Chinese Population

et al. 2013

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Background: Retinopathy of prematurity (ROP) is a gestational age (GA)-related illness that can lead to blindness in premature infants. Timely screening of premature infants could improve visual prognosis. Objective: To evaluate the WINROP algorithm as a method of predicting severe ROP in a Chinese population. Methods: 590 infants with a GA <32 weeks wereentered into an online surveillance system (www.winrop.com) that included ROP evaluations and weekly weight measurements from birth to a corrected GA of 40 weeks. If the rate of weight gain decreased to a certain degree, the algorithm signaled an alarm that the infant was at risk for developing sight-threatening ROP. Each infant was categorized as having no, mild, or severe ROP. Results: Among the 590 infants with a GA <32 weeks, an alarm was triggered in 85 infants (14.4%), 50 of which developed severe ROP and were identified in this alarm group. Twenty-seven infants triggered the alarm signal in the first week after birth and 7 infants triggered the alarm at birth. Seven of the infants developed proliferative ROP and the median GA at birth for these infants was 31 weeks. Conclusions: The WINROP system had a sensitivity of 87.5% in a Chinese population for the early identification of infants that developed severe ROP. Postnatal weight gain may help predict ROP in lower birth weight infants.

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Adjusted poor weight gain for birth weight and gestational age as a predictor of severe ROP in VLBW infants

Cited by 42 publications

References 20 publications

The association between respiratory tract Ureaplasma urealyticum colonization and severe retinopathy of prematurity in preterm infants ≤1250 g

The association between respiratory tract Ureaplasma urealyticum colonization and severe retinopathy of prematurity in preterm infants ≤1250 g

A predictive score for retinopathy of prematurity in very low birth weight preterm infants

The Use of the WINROP Screening Algorithm for the Prediction of Retinopathy of Prematurity in a Chinese Population

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