Adjustable Hyperthermia Response of Self‐Assembled Ferromagnetic Fe‐MgO Core–Shell Nanoparticles by Tuning Dipole–Dipole Interactions

Martínez-Boubeta, C.; Simeonidis, K.; Serantes, David; Conde-Leborán, Iván; Kazakis, Ioannis; Stefanou, G.D.; Peña, Luis Fabián; Galceran, Regina; Balcells, Ll.; Monty, C.; Baldomir, D.; Mitrakas, Manassis; Angelakeris, M.

doi:10.1002/adfm.201200307

Cited by 143 publications

(151 citation statements)

References 37 publications

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“…All of these parameters have influence and it is delicate to explain with certainty the origin of SAR variation within the series. For instance, it was reported that concentration has a strong influence on SAR values through dipolar interactions 45,46,47 and it seems to partly correlate with SAR variations in our set of data.…”

Section: Magnetic Characterization Of Functionalized Mncsmentioning

confidence: 56%

Large scale production of biocompatible magnetite nanocrystals with high saturation magnetization values through green aqueous synthesis

Marciello

Connord

Veintemillas-Verdaguer

et al. 2013

J. Mater. Chem. B

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In this work, a straightforward aqueous synthesis for mass production (up to 20 g) of uniform and crystalline magnetite nanoparticles with a core sizes between 20 and 30 nm, which are the optimum nanoparticle core sizes for hyperthermia application, is proposed. Magnetic and heating properties have been analyzed showing very high saturation magnetization and magnetic heating values. To stabilize the naked magnetite nanocrystals at physiological pH and increase their circulation time in blood, they have been covalently coated with carboxy-methyl-dextran, a biocompatible polymer.The influence of this superficial modification on magnetic and heating properties has been studied showing that these biocompatible magnetic nanocrystals maintain high magnetization saturation values, good colloidal stability and hyperthermia properties in the presence of the polymeric external layer. These particles, properly functionalized, could be used to selectively kill cancer cells under a moderate alternating magnetic field (44 mT and 70 kHz).

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Section: Magnetic Characterization Of Functionalized Mncsmentioning

confidence: 56%

Large scale production of biocompatible magnetite nanocrystals with high saturation magnetization values through green aqueous synthesis

Marciello

Connord

Veintemillas-Verdaguer

et al. 2013

J. Mater. Chem. B

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“…When MNPs can be considered as sin gle-do main and magnetically indep endent, underlying mechan isms are now well-und erstood [1,2]. However, several experimental and theoretical studies have shown that the p resence of magnetic interactions between MNPs dramatically influence their SAR [3,4,5,6,7,8,9,10]. When MNPs are small enou gh to clearly have a sup erp aramagn etic behaviour, the influence of magnetic interactions is relatively simple: magnetic interactions increase their effective anisotropy [3]; in most cases, this is exp ected to enhance their susceptibility and SAR by bringin g them closer to the sup erp aramagn etic/ferro magnetic transition.…”

Section: Introductionmentioning

confidence: 99%

“…Influence of magnetic interactions in these latter is more comp lex and ap p arently contradictory results have been found. Exp erimentally , an increase [5], a decrease [7,8] or a non-monotonic [10] variation of SAR with interactions have been rep orted. In our group, quantitative analy sis of SAR measurements on two different typ es of single-do main M NPs (FeCo and Fe) had led us to conclude that magnetic interactions decrease SAR [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…In our group, quantitative analy sis of SAR measurements on two different typ es of single-do main M NPs (FeCo and Fe) had led us to conclude that magnetic interactions decrease SAR [11,12]. From a theoretical p oint of view, most theoretical works agree that the general trend is that SAR decreases with interactions [3,8,9, 10] although a limited increase in a restricted range of NP concentration has also been rep orted [9,10]. Excep t Ref.…”

Section: Introductionmentioning

confidence: 99%

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Increase of magnetic hyperthermia efficiency due to dipolar interactions in low-anisotropy magnetic nanoparticles: Theoretical and experimental results

et al. 2013

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Abstract:When magnetic n anop articles (MNPs) are single-domain and magnetically indep endent, their magnetic p rop erties and the conditions to optimize their efficiency in magnetic hyp erthermia app lications are now well-understood. However, the influence of magn etic interactions on magnetic hy p erthermia prop erties is still unclear. Here, we rep ort hyp erthermia and highfrequency hy steresis loop measurements on a model system consisting of M NPs with the same size but a vary ing anisotropy , which is an interesting way to tune the relative strength of magnetic interactions. A clear correlation between the M NP anisotropy and the squareness of their hy steresis loop in colloidal solution is observed : the larger the anisotropy, the smaller the squareness. Sin ce low anisotropy MNPs disp lay a squareness high er than the one of magnetically indep endent nanoparticles, magnetic interactions enhance their heatin g p ower in this case. Hysteresis loop calculations of indep endent and coup led M NPs are comp ared to exp erimental results. It is shown that the observed features are a natural consequence of the formation of chains and colu mns of MNPs during hyp erthermia exp eriments: in these structures, when the MNP magnetocristallin e anisotropy is small enough to be dominated by magnetic interactions, the hy steresis loop shap e tends to be rectan gular, which enhan ce their efficien cy. On the contrary , when MNPs do not form chains and columns, magn etic interactions reduces the hy steresis loop squareness and the efficiency of M NPs comp ared to indep endent ones. Our finding can thus exp lain contradictory results in the literature on the influence of magnetic interactions on magnetic hyp erthermia. It also p rovides an alternative exp lanation to some experiments where an enhanced specific absorp tion rate for M NPs in liqu ids has b een found comp ared to the one of MNPs in gels, usually interp reted with some contribution of the brownian motion. The p resent work should improve the understanding and interp retation of magnetic hyp erthermia exp eriments.

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“…Assembly of nanoparticles offers an interesting approach to the design of new magnetic materials and devices, such as permanent magnets for electric cars, 1 spintronic memory and magnetic logic that may form the basis for ultra-low energy computing, 2 soft magnetic materials for high frequency magnetic sensors, 3 and biomedical technology for hyperthermia treatment. 4 Moreover, arrays of nanomagnets may serve as model systems to explore new fundamental physics, such as emergent magnetic monopoles 5 and magnetic frustration in 2-dimensional (2D) artificial spin ice systems. 6 The emergent magnetism in ensembles of interacting nanomagnets that would be superparamagnetic if decoupled is referred to as supermagnetism.…”

mentioning

confidence: 99%

Tailoring the magnetic order in a supermagnetic metamaterial

et al. 2017

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The emergent magnetism in close-packed assemblies of interacting superparamagnetic particles is commonly referred to as supermagnetism. The magnetic characteristics of such systems are determined by the dipolar coupling between the nanomagnets, rather than the exchange interaction responsible for ferro- and antiferromagnetism in continuous material. The dipolar coupling facilitates tuning of the magnetism, which renders supermagnetic ensembles suitable model systems for exploration of new physics. In this work, we discuss micromagnetic simulations of regular arrays of thin film nanomagnets, with magnetic material parameters typical of the ferromagnetic oxide La0.7Sr0.3MnO3. The ground state supermagnetic order in these systems is primarily determined by the lattice configuration, in that a square lattice results in antiferromagnetic order, whereas a triangular lattice shows ferromagnetic order. We found that a square lattice of circular nanomagnets may be switched from superferromagnetic to superantiferromagnetic order by a small external field applied in the appropriate direction.

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Adjustable Hyperthermia Response of Self‐Assembled Ferromagnetic Fe‐MgO Core–Shell Nanoparticles by Tuning Dipole–Dipole Interactions

Cited by 143 publications

References 37 publications

Large scale production of biocompatible magnetite nanocrystals with high saturation magnetization values through green aqueous synthesis

Large scale production of biocompatible magnetite nanocrystals with high saturation magnetization values through green aqueous synthesis

Increase of magnetic hyperthermia efficiency due to dipolar interactions in low-anisotropy magnetic nanoparticles: Theoretical and experimental results

Tailoring the magnetic order in a supermagnetic metamaterial

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