Adjustable degradation and drug release of a thermosensitive hydrogel based on a pendant cyclic ether modified poly(ε-caprolactone) and poly(ethylene glycol)co-polymer

Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery

“…Therefore, nanoparticles formed by amphiphilic polycations with these polyesters have quite stiffer cores. These stiffer cores provided stability of polyplexes in physiological fluids and degradable backbone of nanoparticles, but the compact cores lead to a slow degradation rate in cells [30,31]. It has been confirmed that copolymerizing CL and DLLA in various ratio could adjust the stiffness and degradation rate of implant in tissue engineering [32] as well as the drug release from drug-loaded NPs with PCL/ PDLLA hybrid cores [33].…”

Sustained intravitreal delivery of dexamethasone using an injectable and biodegradable thermogel

“…Recently, biodegradable thermogelling hydrogels which undergo a reversible sol-gel transition upon heating to body temperature have gained increased attention as a minimally invasive depot system for drug delivery, tissue engineering, etc. [16][17][18][19][20][21][22]. Chemical drugs, bioactive macromolecules, and even cells can be incorporated into the polymer aqueous solution at low or room temperature.…”

pH Sensitive Hydrogel Based on Poly(Acrylic Acid) and Cellulose Nanocrystals

“…Natural characteristics such as soft, flexible, elastic and wet nature make hydrogel a frontrunner in various fields including biomedical (Censi et al 2011;Wang et al 2012;Zuidema et al 2011), metal nanoparticles preparation (Sahiner 2013), contact lenses (Sorbara et al 2009), heavy metal ion removal (Wu & Li 2013) and dye removal (Shirsath et al 2013). Although many researches has been focusing on preparing hydrogel from natural occurring polymer, but the versatile properties of synthetic hydrogel had given them a distinctive advantage which in turn broaden their practical utility.…”