Adjustable conduits for guided peripheral nerve regeneration prepared from bi-zonal unidirectional and multidirectional laminar scaffold of type I collagen

Millán, Diana; Jimenez, Ronald; Nieto, Luis Eduardo; Poveda, Ivan Y.; Torres, María Ángeles; Silva, Ana Sofia; Ospina, Luís Fernando; Mano, João F.; Fontanilla, Marta R.

doi:10.1016/j.msec.2020.111838

Cited by 6 publications

(3 citation statements)

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“…In one study, laminar scaffolds of collagen containing zones of unidirectional and multidirectional channels showed cell adhesion, directional proliferation, and differentiation of human adipose stem cells in vitro. In vivo results showed the scaffolds adjustability to the diameter of the nerve stumps as well as enhanced nerve regeneration in 10 mm rat sciatic nerve injury model 120 . Another study developed a collagen gel enriched with magnetic nanoparticles coated with nerve growth factors capable of being actuated remotely 121 .…”

Section: Neuronal Tissue Engineeringmentioning

confidence: 99%

“…In vivo results showed the scaffolds adjustability to the diameter of the nerve stumps as well as enhanced nerve regeneration in 10 mm rat sciatic nerve injury model. 120 Another study developed a collagen gel enriched with magnetic nanoparticles coated with nerve growth factors capable of being actuated remotely. 121 These therapeutic conduits also demonstrated oriented and directed axonal growth, and improved nerve regeneration in 10 mm sciatic rat injury models.…”

Section: Peripheral Nervous Systemmentioning

confidence: 99%

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Cell‐instructive biomaterials in tissue engineering and regenerative medicine

Adhikari

Stager

Krebs

2023

J Biomedical Materials Res

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The field of biomaterials aims to improve regenerative outcomes or scientific understanding for a wide range of tissue types and ailments. Biomaterials can be fabricated from natural or synthetic sources and display a plethora of mechanical, electrical, and geometrical properties dependent on their desired application. To date, most biomaterial systems designed for eventual translation to the clinic rely on soluble signaling moieties, such as growth factors, to elicit a specific cellular response. However, these soluble factors are often limited by high cost, convoluted synthesis, low stability, and difficulty in regulation, making the translation of these biomaterials systems to clinical or commercial applications a long and arduous process. In response to this, significant effort has been dedicated to researching cell‐directive biomaterials which can signal for specific cell behavior in the absence of soluble factors. Cells of all tissue types have been shown to be innately in tune with their microenvironment, which is a biological phenomenon that can be exploited by researchers to design materials that direct cell behavior based on their intrinsic characteristics. This review will focus on recent developments in biomaterials that direct cell behavior using biomaterial properties such as charge, peptide presentation, and micro‐ or nano‐geometry. These next generation biomaterials could offer significant strides in the development of clinically relevant medical devices which improve our understanding of the cellular microenvironment and enhance patient care in a variety of ailments.

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Section: Neuronal Tissue Engineeringmentioning

confidence: 99%

Section: Peripheral Nervous Systemmentioning

confidence: 99%

Cell‐instructive biomaterials in tissue engineering and regenerative medicine

Adhikari

Stager

Krebs

2023

J Biomedical Materials Res

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“…Equipping the nerve repair scaffold with a directional internal structure to guide SCs and axons towards regeneration in the distal target organ, incorporating a porous structure to facilitate material exchange inside and outside the nerve conduit, and ensuring excellent biocompatibility to create a conducive microenvironment for nerve regeneration are effective strategies to prevent nerve transection injuries from progressing into traumatic neuromas (Figure 4d-f). Millán et al developed a porous nerve repair scaffold with directional channels using type I collagen, an excellent biocompatible material [79]. This design aimed to achieve the swift repair and precise docking of 10 mm peripheral nerve defects, thereby preventing the formation of traumatic neuromas.…”

Section: Biomaterial-based Scaffoldsmentioning

confidence: 99%

Strategies for Treating Traumatic Neuromas with Tissue-Engineered Materials

Wan,

Li,

Qin

et al. 2024

Biomolecules

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Neuroma, a pathological response to peripheral nerve injury, refers to the abnormal growth of nerve tissue characterized by disorganized axonal proliferation. Commonly occurring after nerve injuries, surgeries, or amputations, this condition leads to the formation of painful nodular structures. Traditional treatment options include surgical excision and pharmacological management, aiming to alleviate symptoms. However, these approaches often offer temporary relief without addressing the underlying regenerative challenges, necessitating the exploration of advanced strategies such as tissue-engineered materials for more comprehensive and effective solutions. In this study, we discussed the etiology, molecular mechanisms, and histological morphology of traumatic neuromas after peripheral nerve injury. Subsequently, we summarized and analyzed current nonsurgical and surgical treatment options, along with their advantages and disadvantages. Additionally, we emphasized recent advancements in treating traumatic neuromas with tissue-engineered material strategies. By integrating biomaterials, growth factors, cell-based approaches, and electrical stimulation, tissue engineering offers a comprehensive solution surpassing mere symptomatic relief, striving for the structural and functional restoration of damaged nerves. In conclusion, the utilization of tissue-engineered materials has the potential to significantly reduce the risk of neuroma recurrence after surgical treatment.

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Natural Polymer‐Derived Bioscaffolds for Peripheral Nerve Regeneration

Zhang

Guo

Wang

et al. 2022

Adv Funct Materials

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In recent decades, artificial nerve scaffolds have become a promising substitute for peripheral nerve repair. Considerable efforts have been devoted to improving the therapeutic effectiveness of artificial scaffolds. Among numerous biomaterials for tissue engineering scaffolds fabrication, natural polymers are considered as tremendous candidates because of their excellent biocompatibility, low toxicity, high cell affinity, wide source, and environmental protection. With the development of engineering technology, a variety of natural polymer-derived nerve scaffolds have emerged, which are endowed with biological properties and appropriate physicochemical performances to gradually adapt to the needs of nerve regeneration. Significantly, the intergradation of exogenous biomolecules onto the artificial scaffolds is able to avoid low stability, rapid degradation, and redistribution of direct therapeutic drugs in vivo, thereby enhancing nerve regeneration and functional reconstruction. Here, the development of nerve scaffolds derived from natural polymers, and their applications in continuous administration and peripheral nerve regeneration are comprehensively and carefully reviewed, providing an advanced perspective of the field.

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Adjustable conduits for guided peripheral nerve regeneration prepared from bi-zonal unidirectional and multidirectional laminar scaffold of type I collagen

Cited by 6 publications

References 50 publications

Cell‐instructive biomaterials in tissue engineering and regenerative medicine

Cell‐instructive biomaterials in tissue engineering and regenerative medicine

Strategies for Treating Traumatic Neuromas with Tissue-Engineered Materials

Natural Polymer‐Derived Bioscaffolds for Peripheral Nerve Regeneration

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