Adjunctive Use of Statins for COVID-19

Sathekge, Mike; Byttebier, Geert; Spiegeleer, Bart De; Saxberg, Bo E.H.; Ueckermann, Veronica; Belmans, Luc; Alexander, Mathew; Fedson, David S.

doi:10.3390/jcm10071407

Cited by 1 publication

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, it should be mentioned here that there has not been enough research conducted with regard to the experiences with AT receptor blockers/ACE inhibitors and their effects on the progression of COVID‐19. 94 , 95 , 96 , 97 …”

Section: Systemic Physiology and Pathologymentioning

confidence: 99%

“…Integrating RAAS into the conceptualisation of the immune system with its pro‐ and anti‐inflammatory functions and its innate and adaptive cellular components in the view of a systemic functional analysis leads to a network model with imbalanced interactions, resulting in a hyper‐inflammatory state of the cellular matrix (Figure 3). Interestingly, it should be mentioned here that there has not been enough research conducted with regard to the experiences with AT receptor blockers/ACE inhibitors and their effects on the progression of COVID‐19 94–97 …”

Section: Systemic Physiology and Pathologymentioning

confidence: 99%

See 1 more Smart Citation

Perspectives of (/memorandum for) systems thinking on COVID‐19 pandemic and pathology

Tretter

Peters

Sturmberg

et al. 2022

Evaluation Clinical Practice

View full text Add to dashboard Cite

Is data‐driven analysis sufficient for understanding the COVID‐19 pandemic and for justifying public health regulations? In this paper, we argue that such analysis is insufficient. Rather what is needed is the identification and implementation of over‐arching hypothesis‐related and/or theory‐based rationales to conduct effective SARS‐CoV2/COVID‐19 (Corona) research. To that end, we analyse and compare several published recommendations for conceptual and methodological frameworks in medical research (e.g., public health, preventive medicine and health promotion) to current research approaches in medical Corona research. Although there were several efforts published in the literature to develop integrative conceptual frameworks before the COVID‐19 pandemic, such as social ecology for public health issues and systems thinking in health care, only a few attempts to utilize these concepts can be found in medical Corona research. For this reason, we propose nested and integrative systemic modelling approaches to understand Corona pandemic and Corona pathology . We conclude that institutional efforts for knowledge integration and systemic thinking, but also for integrated science, are urgently needed to avoid or mitigate future pandemics and to resolve infection pathology.

show abstract