Adjunctive use of saturated solution of potassium iodide (SSKI) with liposomal amphotericin B (L-AMB) in mucormycosis achieves favorable response, shortened dose and duration of amphotericin: A retrospective study from a COVID-19 tertiary care center

Mrig, Sumit; Sardana, Kabir; Arora, Pooja; Narula, Vineet; Arora, Sandeep; Kapoor, A.; Baruah, Ritu Raj; Sen, Purnendu; Agarwal, Shweta; Sachdeva, Sandeep; Dewan, Arun; Panesar, Sanjeet

doi:10.1016/j.amjoto.2022.103465

Cited by 6 publications

(4 citation statements)

References 31 publications

(32 reference statements)

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“…Six patients (24%) necessitated alveolectomy during the second week of treatment following initial stage debridement. 11 Limited evidence from a retrospective review suggests an "aggressive conservative" approach. This strategy involves utilizing intraoperative frozen sections to delineate infected tissue margins and sparing uninvolved tissues from debridement whenever feasible.…”

Section: Surgical Managementmentioning

confidence: 99%

Evolution of mucormycosis – Systematic review and meta-analysis

Padmanabhan,

Ravichandran,

Radhakrishnan

2024

IJASHNB

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The outbreak of COVID-19, caused by the novel coronavirus SARS-CoV-2, has been linked to a notable rise in mucormycosis cases, particularly evident during the second wave in the summer of 2021. Mucormycosis, characterized by its aggressive nature and high mortality rates, requires rapid identification and intervention. Factors such as poorly controlled blood sugar levels, corticosteroid usage, and COVID-19-related immune compromise are significant contributors to its development. The objective of this review is to analyze the incidence, progression, clinical manifestations, and treatment approaches of mucormycosis, drawing from a selection of 16 pertinent articles published between 2009 and 2022, and accessed through databases like PubMed and Google Scholar.

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Section: Surgical Managementmentioning

confidence: 99%

Evolution of mucormycosis – Systematic review and meta-analysis

Padmanabhan,

Ravichandran,

Radhakrishnan

2024

IJASHNB

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“…La hiperglucemia aumenta la disponibilidad de hierro libre, regula el alza de los niveles de expresión de GRP78 y CotH3, y conduce a la disfunción inmune, desarrollando condiciones favorables para el crecimiento de hongos y la invasión del endotelio P á g i n a 494 del huésped. Además, se altera la actividad de los fagocitos y los neutrófilos, con afección de la quimiotaxis funcional y los mecanismos de destrucción oxidativa y no oxidativa (Arora et al, 2022).…”

Section: Hiperglucemiaunclassified

“…Mrig et al informaron el uso de una solución saturada de yoduro de potasio (SSKI) con anfotericina-B liposomal como terapia adyuvante contra R. arrhizus. La administración oral de SSKI redujó la dosis y la duración del tratamiento con anfotericina-B (Mrig et al, 2022).…”

Section: Terapia Adyuvanteunclassified

Mucormicosis pulmonar asociada a SARS- CoV-2

Taipe

Teneda

2023

Ciencia Latina

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La infección fúngica invasiva provocada por hongos del orden Mucorales es conocida como mucormicosis. Esta enfermedad se ha convertido en una preocupación global debido a su alta tasa de mortalidad y morbilidad, especialmente en el contexto de la pandemia por el COVID-19. La revisión se enfoca en la incidencia, fisiopatología y factores de riesgo de la enfermedad, así como en los procedimientos de diagnóstico actuales. Se sugiere la necesidad de desarrollar ensayos más específicos y rentables, como los basados en PCR y anticuerpos monoclonales, para un diagnóstico eficaz. La revisión también aborda las opciones de tratamiento actuales, incluyendo terapias con medicamentos antimicóticos, adyuvantes y debridación quirúrgica, así como la importancia de la terapia basada en nutracéuticos. Además, se destaca la necesidad de explorar nuevas opciones de tratamiento, como la terapia basada en anticuerpos, citocinas y terapia antimicótica combinada/sinérgica. También señala las brechas de investigación actuales y la necesidad de desarrollar en el futuro estudios en el campo de la mucormicosis pulmonar asociada a COVID-19 .

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“…Intravitreal AMB may be useful in patients with endophthalmitis [11]. Significantly, uses of the saturated solution of potassium iodide have been discussed to shorten the duration and dose of AMB [33]. Hyperbaric oxygen may be adjunct management to improve outcomes, but no controlled studies have shown its efficacy [34].…”

Section: Managementmentioning

confidence: 99%

Rhino-orbital mucormycosis

Ryu

Laylani

Davila-Siliezar

et al. 2022

Current Opinion in Ophthalmology

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Purpose of reviewThe current article will update and review the clinical and radiological manifestations and management of rhino-orbital mucormycosis (ROM).Recent findingsThere has been an increase in cases of ROM worldwide, especially in India. Immunosuppression (especially diabetes mellitus) is a known predisposing risk factor for ROM. Delayed diagnosis and treatment of ROM can be vision or life-threatening. This article reviews the clinical and radiologic features, treatment, and prognosis of ROM with special emphasis on new and emerging therapies.SummaryROM is an angioinvasive fungal infection that affects the sinuses and orbits and may present to ophthalmologists. Clinicians should have a high index of suspicion for ROM, especially in patients with poorly controlled diabetes mellitus or other immunosuppression. Corticosteroid treatment (including the recent COVID-19 pandemic) may be a predisposing risk factor for ROM.

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Adjunctive use of saturated solution of potassium iodide (SSKI) with liposomal amphotericin B (L-AMB) in mucormycosis achieves favorable response, shortened dose and duration of amphotericin: A retrospective study from a COVID-19 tertiary care center

Cited by 6 publications

References 31 publications

Evolution of mucormycosis – Systematic review and meta-analysis

Evolution of mucormycosis – Systematic review and meta-analysis

Mucormicosis pulmonar asociada a SARS- CoV-2

Rhino-orbital mucormycosis

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