Adjunctive Use of Hyaluronic Acid Gel (Restylane Sub-Q) in Anophthalmic Volume Deficient Sockets and Phthisical Eyes

Abstract

Hyaluronic acid gel injections in patients with enophthalmic sockets appear to be a safe, tolerable, and minimally invasive alternative for orbital volume augmentation in the outpatient setting. However, as predicted, its affects are temporary, and volume does begin to decrease within 12 months of injection.

Orbital Volume Augmentation After Injection of Human Orbital Adipose-Derived Stem Cells in Rabbits

“…It is important to note that none of these patients had added risks for visual loss, ocular motility disturbance, or other problems with the injections associated with a seeing eye. 21 Although the effect of the HAG filler was not sustained for long after its absorption, its advantages FIGURE 6. Change in the exophthalmometric value in rabbits after injection with HAG only, HAG þ hoSVF, or HAG þ hoADSCs.…”

“…22,23 Another injectable alternative is autologous fat transfer as an intraconal, extraconal, or periorbital injection. 21 This technique has the advantages of no risks for rejection, sensitivity reactions, or nodules. 20 However, the duration of its effect was limited when it was injected in the face.…”

Non-aesthetic indications for periocular hyaluronic acid filler treatment: a review

“…Restylane Sub-Q (Q-Med, Uppsala, Sweden) was further evaluated in a relatively large prospective case series involving 16 patients with orbital volume deficiency in orbits with phthisical eyes (3 patients) or anophthalmia following enucleation or evisceration (10 and 3 patients, respectively) 28. The authors describe forming a ‘lake’ of filler with either a single or double bolus with placement confirmed on postinjection imaging.…”

Hyaluronic acid gel implants for correction of pathological conditions of the orbit and eyelids

“…За последнее десятилетие в зарубежной и российской литературе опубликован ряд исследований, посвященных эффективности и безопасности применения ГГК с частицами малого диаметра (400 мкм) при различных патологических состояниях век (ретракция, аномалии положения), сопровождающихся развитием лагофтальма [1][2][3], а также большего диаметра (2000 мкм) с целью малоинвазивной коррекции энофтальма или анофтальмического синдрома [4][5][6][7].…”