Adjunctive psychotherapy for bipolar disorder: Effects of changing treatment modality.

Frank, Ellen; Swartz, Holly A.; Mallinger, Alan G.; Thase, Michael E.; Weaver, Elizabeth V.; Kupfer, David J.

doi:10.1037/0021-843x.108.4.579

Cited by 99 publications

(67 citation statements)

References 21 publications

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“…The Maintenance Therapies in Bipolar Disorder (MTBD-MH29618, E. Frank, Principle Investigator; Frank et al 1999) study is an ongoing randomized trial of Interpersonal and Social Rhythm Therapy (IPSRT; Frank et al 1994) versus an intensive clinical management (CM) control condition across both preliminary and preventative phases of treatment. Patients enter the study in the preliminary phase, during which acute treatment consisting of protocol pharmacotherapy and either IP-SRT or CM is provided for their index episode of either mania or depression.…”

Section: Methodsmentioning

confidence: 99%

Variability of Erythrocyte and Serum Lithium Levels Correlates with Therapist Treatment Adherence Efforts and Maintenance Treatment Outcome

Taylor

Mallinger

Frank

et al. 2001

Neuropsychopharmacology

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This study investigated the relationship between psychotherapeutic interventions and pharmacologic measures of pharmacotherapy treatment adherence in patients with bipolar I disorder, as well as the relationshipIt is widely recognized that many people with bipolar disorder have difficulty adhering to prescribed medication (Goodwin and Jamison 1990;Cochran and Gitlin 1988;Cochran 1984;Jamison and Akiskal 1983). Estimates of lithium noncompliance range from 20% to 66% (Cochran and Gitlin 1988) in such patients. Psychotherapy is frequently employed as an adjunctive treatment strategy for bipolar disorder; however, it is not clear to what extent such intervention might enhance medication treatment adherence in this patient population. We hypothesized that therapists' efforts targeted at enhancing pharmacotherapy treatment adherence would be associated with physiologic measures of treatment adherence and clinical outcome. Therefore, we initiated a study aimed at evaluating the outcome of therapists' interventions directed toward pharmacotherapy treatment adherence, as reflected by both pharmacologic measures of treatment adherence and rates of episode recurrence. Written informed consent was obtained from all participants in the MTBD study apprising them of both the study description and of the possible use of the data for additional research. At the time this study was conducted, 155 patients had been entered into the MTBD protocol. Our initial eligibility criterion for inclusion in our study was that of having been in the maintenance phase of the MTBD study for at least 1 year. This led to a pool of 63 eligible patients. The resulting sample of patients was selected utilizing the following inclusion criteria: (1) three audiotaped, ratable sessions from the first 3 months of the preventative phase; (2) five blood level determinations [which we considered the minimum to estimate standard deviation (SD) with accuracy] within 8 months of beginning the preventative phase, three of which were required to be from the first 3 months in order to correspond with the time period of the selected audiotapes; (3) being treated with lithium; and (4) remaining clinically stable during the time period when all blood level data were collected. For patients who had recurrences, all data were collected prior to the time of recurrence. Reasons for tapes not being ratable included the following: occasionally malfunctioning equipment, taping errors by the clinicians, and lost or inaudible tapes. Of the original pool of 63 eligible patients, six could not be included based on criterion 1; 17 could not be included based on criterion 2; one could not be included based on criterion 3; and eight could not be included based on criterion 4. Outcome was categorized as either recurrence or completion of 2 years maintenance without recurrence. One additional patient who dropped out of the MTBD study before a categorizable outcome could be determined was excluded. METHODSThirty patients were eligible for inclusion in this study. For 29 of these, we...

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Section: Methodsmentioning

confidence: 99%

Variability of Erythrocyte and Serum Lithium Levels Correlates with Therapist Treatment Adherence Efforts and Maintenance Treatment Outcome

Taylor

Mallinger

Frank

et al. 2001

Neuropsychopharmacology

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“…als «interpersonell-interaktional», «systemisch» oder als «Ehetherapie» [Chase und Kelly, 1993;Mayo, 1979;Retzer et al, 1991;Shakir et al, 1979;Volkmar et al, 1981]. Die bevorzugte Therapiemodalität bestand aus Gruppentherapie (10 der 14 Studien; 71,4%), und nur die Studie von Thase et al [1997] Miklowitz et al, 1996]; (2) in einem Fall blieb unklar, ob es sich wirklich um eine Stichprobe manisch-depressiver Patienten handelte [Barkham et al, 1989]; (3) die Auswertung der Daten erfolgte nicht getrennt für Patienten mit einer unipolaren oder bipolaren affektiven Störung [Beardslee et al, 1993;Zieba et al, 1996]; (4) in einer Studie wurden ausschließlich die Partner von bipolaren Patienten behandelt [ van Gent und Zwart, 1991]; (5) in 3 weiteren Fällen handelte es sich um weitgehend die gleiche Stichprobe: Frank et al [1997Frank et al [ , 1999 und Hlastala et al [1997] van Gent und Zwart [1993] unter der Publikation von van Gent et al [1988] subsummiert wurde. Der Versuch, anhand dieser Studien eine Metaanalyse durchzuführen, um eine mittlere Effektstärke abschätzen zu kön-nen, erwies sich als nicht realisierbar.…”

Section: Ergebnisseunclassified

“…Nur bei Cochran [1984] Simoneau et al, 1999]. Jeweils zweimal waren es Paarbehandlungen [Clarkin et al, 1998;Davenport et al, 1977] oder Gruppentherapien [van Gent et al, 1988;Honig et al, 1997], und dreimal waren es Einzeltherapien [Cochran, 1984;Frank et al, 1999;Zaretsky et al, 1999]. Bis auf eine Ausnahme [Clarkin et al, 1990] van Gent et al [1988], und inhaltlich bedeutete dies vor allem die Aufklärung über die Störung.…”

Section: Ergebnisseunclassified

“…Ob auch hinsichtlich Symptomatik oder anderer Aspekte positive Veränderungen beobachtet werden konnten, wurde nicht berichtet. Die von Frank et al [1999] vorgestellten Daten basieren auf einer Therapieform, die in Anlehnung an die Interpersonelle Psychotherapie von Klerman und Mitarbeitern [1984] entwickelt wurde: Die Interpersonelle und Soziale Rhythmus Therapie (IPSRT). Es handelt sich hierbei um einen strukturierten und Manual-geleiteten Ansatz, wobei versucht wird, über drei Mechanismen eine Symptomreduktion zu erreichen: Erhöhung der Compliance, Verbesserung und Stabilisierung der sozialen Rhythmen (z.B.…”

Section: Ergebnisseunclassified

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Psychotherapie bei bipolaren affektiven Störungen – Ein Überblick über den Stand der Forschung

Meyer

Hautzinger

2000

Verhaltenstherapie

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Psychotherapy of Bipolar Affective Disorder – A Review of the Research Evidence Purpose: Numerous controlled therapy studies showed that patients suffering from unipolar depression can be effectively treated with psychotherapy. Such an adjunctive psychotherapy to standard medication is also suggested to be helpful for patients with bipolar affective disorder. We planned to conduct a meta-analysis to test whether this assumption is also empirically based. Methods: We conducted a literature research using Medline, Psyclit, and Psyndex. We considered all publications in journals dealing with the topic ‘psychotherapy and bipolar disorder’ until the end of 1999. This search resulted in 212 English or Geman articles. Results: A more detailed analysis using the criteria ‘diagnosis’, ‘intervention’, ‘sample size’ and ‘outcome measures’ reduced this to 78 and finally 33 papers. Only 19 of these 33 publications were considered as ‘controlled trials’ and only 50% of these were original papers which definitely dealt with a sample of patients with bipolar disorder treated in a controlled trial. These 9 studies were heterogeneous refer-ring to treatment approach, setting, clinical status of the patients, and outcome variables so that we decided against a meta-analysis. Therefore, the controlled studies were de-scribed in some detail. Conclusion: Although the results of these trials somehow argue for the usefulness of adjunctive psychotherapy for bipolar disorder, we still do not know yet whether it is effective at all and who would benefit from which treatment.

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“…The first five studies (Lam et al, 2000;Perry et al, 1999;Scott et al, 2001;Frank et al, 1999) were relatively small scale and used a variety of approaches, but predominantly focused on either cognitive behaviour therapy (CBT) or cognitive and behavioural techniques, or interpersonal social rhythms therapy (IPSRT). These RCTs, which used either treatment as usual or treatment as usual plus support or symptom management sessions as the control condition, demonstrated that psychological treatments appear to have some benefit in preventing relapse, but that the effect was more impressive for total relapses or depressive relapses rather than manic relapses.…”

Section: Introductionmentioning

confidence: 99%

Cognitive-Behavioral Therapy for the Bipolar Disorder Patients

Juruena¹

2012

Standard and Innovative Strategies in Cognitive Behavior Therapy

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Adjunctive psychotherapy for bipolar disorder: Effects of changing treatment modality.

Cited by 99 publications

References 21 publications

Variability of Erythrocyte and Serum Lithium Levels Correlates with Therapist Treatment Adherence Efforts and Maintenance Treatment Outcome

Variability of Erythrocyte and Serum Lithium Levels Correlates with Therapist Treatment Adherence Efforts and Maintenance Treatment Outcome

Psychotherapie bei bipolaren affektiven Störungen – Ein Überblick über den Stand der Forschung

Cognitive-Behavioral Therapy for the Bipolar Disorder Patients

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