Adjunctive probiotics after periodontal debridement versus placebo: a systematic review and meta-analysis

Ng, Ethan; Tay, John Rong Hao; Saffari, Seyed Ehsan; Lim, Lipyeow; Chung, Kong Mun; Ong, Marianne Meng Ann

doi:10.1080/00016357.2021.1942193

Cited by 11 publications

(10 citation statements)

References 69 publications

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“…14 They help to re-establish the balance of flora after a process of dysbiosis, particularly in the oral cavity, creating a biofilm that protects the tissues against pathogens by establishing themselves in areas that they would tend to colonize. 15,16 In oral health, various bacterial strains of probiotics have been recognized for their ability to mitigate certain conditions in the oral cavity: prevention of dental caries, by reducing the levels of Streptococcus mutans, [17][18][19] treatment of oral candidiasis, 20,21 control of halitosis, 22,23 prevention and treatment of periodontal diseases, [24][25][26][27] as well as peri-implant diseases, [28][29][30] with effects on reducing the amount of bacterial plaque and gingival bleeding justified by reducing the concentrations of cytokines that mediate inflammatory processes. 28,31,32 A systematic review and meta-analysis on the impact of various oral probiotics on chronic periodontitis registered significant improvements for all clinical parameters and pathogens studied, when the administration of oral probiotics was performed as adjuvant to scaling and root planing.…”

Section: Introductionmentioning

confidence: 99%

Limosilactobacillus reuteri as an Adjuvant in the Treatment of Peri-implant Mucositis in Total Rehabilitation: An Exploratory Study

Parreira,

de Araújo Nobre,

Moreira

et al. 2024

Eur J Dent

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Objectives Mechanical debridement is the traditional method for the treatment of peri-implant mucositis (P-im) and its success depends on the patient's correct oral hygiene. It is believed that probiotics may help by their ability to modulate the oral biofilm, resulting in anti-inflammatory and antibacterial plaque action. The aim of this study was to evaluate the adjuvant effect of the probiotic Limosilactobacillus reuteri (LR) in the mechanical treatment of P-im. Materials and Methods This exploratory study included 29 subjects with implant-supported total rehabilitation and P-im, divided into test (TG) and control (CG) groups, equally subjected to professional mechanical debridement, with the administration of a daily GUM PerioBalance lozenge for 30 days added to the TG. The modified Plaque Index (mPlI) modified Sulcus Bleeding Index (mBI) and pocket depth (PD) were evaluated before the intervention (baseline) and 6 and 10 weeks later. Statistical Analysis Parametric and nonparametric tests with 5% significance level were used in the statistical analysis, using IBM SPSS Statistics 27.0 software. Results Both treatments resulted in reduced mPlI, mBI, and PD at 6 weeks; while from 6 to 10 weeks there was an increase in mPlI and mBI and maintenance of PD. Compared with baseline, differences were close to statistical significance in the reduction in PD at 10 weeks in the CG (p = 0.018), after Bonferroni correction, and statistically significant in the mPlI at 6 weeks in the CG (p = 0.004) and in the TG (p = 0.002) as well as at 10 weeks in the TG (p = 0.016). Comparing the groups in the postintervention assessments, no statistically significant differences were found. Conclusion LR adjuvant mechanical treatment of P-im does not show a clear benefit compared with mechanical treatment alone, with both interventions achieving similar clinical results. Further prospective and long-term studies are needed.

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Section: Introductionmentioning

confidence: 99%

Limosilactobacillus reuteri as an Adjuvant in the Treatment of Peri-implant Mucositis in Total Rehabilitation: An Exploratory Study

Parreira,

de Araújo Nobre,

Moreira

et al. 2024

Eur J Dent

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“…1 The alteration of oral microbial balance may lead to diseases and antibiotics are a common antimicrobial approach to regain the oral microbiota equilibrium. [2][3][4][5] However, over-reliance on antibiotic administration increases the risk of developing antimicrobial resistance which WHO (World Health Organization) has declared as one the global health emergencies, also known as a silent pandemic. Therefore, an alternative intervention such as probiotics gains attention to maintain oral biofilm homeostasis.…”

Section: Introductionmentioning

confidence: 99%

The antimicrobial effect of Limosilactobacillus reuteri as probiotic on oral bacteria: A scoping review

Ananda,

Suniarti,

Bachtiar

2024

F1000Res

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Dysbiosis among oral microbial community in the oral cavity can lead to several oral diseases. Probiotic therapy is known to correct these imbalances. Limosilactobacillus reuteri is one of the most studied strains of probiotics and can control oral microbiota through reuterin, a wide-spectrum antimicrobial agent. The objective of this review was to evaluate the effect of the antimicrobial activity of Limosilactobacillus reuteri on the oral bacteria of humans. This review used PubMed, Scopus, EMBASE, ScienceDirect, and Google Scholar databases as bibliographic resources. Studies with matching keywords were analyzed and screened with PRISMA-ScR recommendations. Sixteen articles were selected for this review, which included a total of 832 patients. Based on this review, Limosilactobacillus reuteri has a strong antibacterial effect against Streptococcus mutans in healthy individuals but is not effective against Lactobacillus. Additionally, it has a significant antibacterial effect against Porphiromonas gingivalis in patients with periodontitis, although its effectiveness is not stable in patients with peri-implant infections. Furthermore, Limosilactobacillus reuterihas varying results against other bacteria, indicating the need for further extensive research to ensure its efficacy.

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“…The mechanical removal of biofilm (scaling and root planning) is considered the conventional treatment, although it is not always sufficient. Consequently, in many cases, it is essential to consider the use of adjunctive treatments, for example, systemic antibiotics like the combination of amoxicillin and metronidazole [ 5 ] or probiotics [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Combination of Neovestitol and Vestitol Modifies the Profile of Periodontitis-Related Subgingival Multispecies Biofilm

Macedo,

Malavazi,

Vargas

et al. 2024

Biomedicines

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The aim of this study was to evaluate the effect of the combination of neovestitol–vestitol (CNV) compounds obtained from Brazilian red propolis on the microbiological profile of a mature multispecies subgingival biofilm. The biofilm with 32 bacterial species associated with periodontitis was formed for seven days using a Calgary device. Treatment with CNV (1600, 800, 400, and 200 μg/mL), amoxicillin (54 μg/mL), and vehicle control was performed for 24 h on the last day of biofilm formation. Biofilm metabolic activity and DNA–DNA hybridization (checkerboard) assays were performed. The groups treated with CNV 1600 and amoxicillin reduced 25 and 13 species, respectively, compared to the control vehicle treatment (p ≤ 0.05); both reduced P. gingivalis, while only CNV reduced T. forsythia. When the data from the two treatments (CNV and AMOXI) were compared, a statistically significant difference was observed in 13 species, particularly members of Socransky’s orange complex. Our results showed that CNV at 1600 μg/mL showed the best results regarding the metabolic activity of mature biofilms and obtained a reduction in species associated with the disease, such as T. forsythia, showing a better reduction than amoxicillin. Therefore, CNV seems to be a promising alternative to eradicate biofilms and reduce their pathogenicity.

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Adjunctive probiotics after periodontal debridement versus placebo: a systematic review and meta-analysis

Cited by 11 publications

References 69 publications

Limosilactobacillus reuteri as an Adjuvant in the Treatment of Peri-implant Mucositis in Total Rehabilitation: An Exploratory Study

Limosilactobacillus reuteri as an Adjuvant in the Treatment of Peri-implant Mucositis in Total Rehabilitation: An Exploratory Study

The antimicrobial effect of Limosilactobacillus reuteri as probiotic on oral bacteria: A scoping review

Combination of Neovestitol and Vestitol Modifies the Profile of Periodontitis-Related Subgingival Multispecies Biofilm

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